Socioeconomic status and health in the Japanese population

Kagamimori, Sadanobu; Gaina, Alexandru; Nasermoaddeli, Ali

doi:10.1016/j.socscimed.2009.03.030

Cited by 208 publications

(172 citation statements)

References 60 publications

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“…In terms of stratification determined by an individual's socioeconomic position, we would refer to the specific egalitarian characteristic of the Japanese society in support of our claim. 41 In conclusion, our findings and previous studies suggest that IL13, TNF, IL4RA, ADAM33 and TBXA2R might represent the major asthma and asthma-related traits genes common across populations. GSTM1, GSTP1, LTC4S, AAA1, NOS1 and CCL5 along with MMP9, IL12B, C3 and SOCS1 might be additional susceptibility genes, which have stronger effects in the Japanese population.…”

Section: Discussionsupporting

confidence: 68%

Replication of genetic association studies in asthma and related phenotypes

et al. 2010

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In asthma genetics, the association of highly replicated susceptibility genes lacks consistency across populations. To identify genuine associations, we investigated the reproducibility of the 23 most promising asthma and asthma-related candidate genes in a moderately sized sample from the Japanese population. We compared the frequency of 33 polymorphisms in unrelated cases and controls and tested for their association with asthma, atopy and serum total IgE levels using allele frequency, codominant, dominant and recessive genotype models. On the basis of the consistency of our findings with previous metaanalyses and large replication studies, IL13, TNF, ADAM33, IL4RA and TBXA2R might represent common major asthma and asthma-related trait genes. Individual gene assessment was extended to the interactions between two polymorphisms using our original method. Interactions between TBXA2R and ADAM33, and IL4RA and C3 were suggested to increase the risk for childhood and all asthma (adult and childhood asthma combined). The confirmation of previously reported associations between gene polymorphisms and phenotypes was problematic when as few as several hundred samples per group were used. Stratification of the subjects by environmental factors or other confounding factors may be necessary to improve the sensitivity and reliability of association results. Keywords: association; asthma; atopy; polymorphism; replication INTRODUCTIONAsthma is a heritable trait 1 and investigations to determine the genetic components underlying asthma using linkage mapping and the candidate gene approach have been carried out. By 2006, more than 100 genes were associated with asthma and asthma-related phenotypes; 2 25 of these genes have been replicated in more than six independent association studies. In 2008, this list was complemented with an additional three genes, FLG, NAT2 and CCL15. 3 However, no single polymorphic marker or gene locus has been unanimously labeled as a strong and independent genetic determinant of asthma, and the results for the highly replicated genes have been inconsistent across the tested populations. 3 To identify true associations, it is of critical importance to comprehensively replicate the initial finding. 4 To this aim, we investigated whether the 23 most replicated genes for asthma and asthma-related phenotypes were positively associated with extrinsic childhood and adult asthma, atopy and total serum IgE levels in a moderately sized sample drawn from the Japanese population.We also tested eight genes that were significantly associated with asthma in our subjects: IL13, 5 TBXA2R, 6 GSTP1, 7 ADAM33, 8 MMP9, 9 IL12B, 10 C3 11 and SOCS1. 12 The re-evaluation of these associations is

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Section: Discussionsupporting

confidence: 68%

Replication of genetic association studies in asthma and related phenotypes

et al. 2010

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“…Although no research has been conducted on this topic in Japan, studies have pointed out a link between SES and smoking and excessive consumption of alcohol 41,42) . Our study identified a high risk for smoking among all precarious workers engaged in full-time jobs.…”

Section: Discussionmentioning

confidence: 99%

Precarious Employment and Health: Analysis of the Comprehensive National Survey in Japan

2012

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Recent studies suggest that unstable employment contracts may affect the health of workers. Many Japanese workers working full time in ostensibly permanent positions actually operate within unstable and precarious employment conditions. We compared the health status of Japanese workers with precarious employment contracts with that of permanent workers using the 2007 Comprehensive Survey of Living Conditions of the People on Health and Welfare (n=205,994). We classified their employment status as 'permanent' vs. 'precarious' (part-time, dispatch, or contract/ non-regular) and compared their health conditions. Among both sexes, precarious workers were more likely than permanent workers to have poor self-rated health or more subjective symptoms, with more workers in full-time employment suffering from serious psychological distress (SPD) and more female workers who smoke. Using logistic regression, we identified a positive association between precarious employment and SPD and current smoking among workers engaged in fulltime employment after adjusting for age, marital status, and work-related conditions. This study demonstrates that precarious employment contracts are associated with poor self-rated health, psychological distress, and tobacco use, especially among people working full-time jobs. These results suggest that engagement in full-time work under unstable employment status impairs workers' health.

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“…This striking pattern may well reflect both beneficial and adverse effects of maternal employment on children's health. As women have become more active throughout society, the potential impacts of maternal employment may be further intensified and affect childhood overweight, widening the health disparities across social classes in Japan [38][39][40][41][42][43] . With the employment pattern becoming diversified 10) , future studies should aim to elucidate the association between maternal employment and early childhood overweight by carefully assessing the maternal employment patterns from the life-course perspective.…”

Section: Discussionmentioning

confidence: 99%