The study examined the perception of Anambra state residents toward media campaigns against the consumption of uncertified herbal medicine. The essence of the study was to determine the extent of exposure of the residents to media campaigns against the consumption of uncertified herbal medicine. Study adopted two theoretical frameworks, and a survey research method was used. The study found, among others, that a majority of the respondents were moderately exposed to media campaigns against the consumption of uncertified herbal medicine; radio was the medium through which most of the respondents accessed media campaigns against the consumption of uncertified herbal medicine. Further findings revealed that the media campaigns against consumption of uncertified herbal medicine among the residents have not been so effective. The study concluded that the media campaigns against the consumption of uncertified herbal medicine convey uncertainty, a grey area by Anambra state residents. Thus, the study recommended that media should actively shed light on the dangers of consuming uncertified herbal medicine, committing themselves to features, editorials, radio presentations, news programmes, call-in-programs, and documentaries, among others.