SOCS2 modulates adipose tissue inflammation and expansion in mice

Val, Cynthia H; Oliveira, Marina C.; Lacerda, Débora Romualdo; Barroso, Andréia; Batista, Nathália Vieira; Menezes‐Garcia, Zélia; Assis, Diego Rodney Rodrigues de; Cramer, Allysson; Brant, Fátima; Teixeira, Mauro Martins; Souza, Danielle G.; Ferreira, AdalieneVersiani M.; Machado, Fabiana S.

doi:10.1016/j.jnutbio.2019.108304

Cited by 26 publications

(12 citation statements)

References 48 publications

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“…An experiment in mice indicated that SOCS2 is a modulator of obesity via regulating the metabolic pathways depending on adipocytes' size. Moreover, SOCS2 also serves as an inflammatory regulator through controlling cell differentiation or recruitment into adipose tissue and cytokines release during the progression of obesity [50] . Another study proved that SOCS2 plays a protective role in acute liver injury through balancing immune response and oxidative stress [51] .…”

Section: Discussionmentioning

confidence: 99%

A Novel Nomogram Based on Lipid Metabolism-Related Risk Gene Expression Can Better Predict Overall Survival for Hepatocellular Carcinoma

Lu¹,

Hu²,

Zeng³

et al. 2021

Preprint

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Metabolic reprogramming has been proven to be a hallmark of cancer. The pathogenic factors involved in Hepatocellular carcinoma (HCC) lead to an abnormal lipid metabolism that facilitates the malignant transformation of liver cells . However, the association between lipid metabolism and the prognosis of HCC has not been systematically delineated. In this study, the training set comprised 221 patients from The Cancer Genome Atlas (TCGA) based on the gene expression details, whereas 230 patients within the International Cancer Genome Consortium (ICGC) comprised the validation set. Ten lipid metabolism-related risk genes were screened; they were found to be significantly related to the prognosis of HCC. The risk score was calculated based on ten screened lipid metabolism-related risk genes and was confirmed to be an independent prognostic factor for HCC even when excluding clinical features. Therefore, a novel nomogram integrating the risk score and other proven clinical attributes was constructed. The results of the area under the receiver operating characteristics curve (AUC), C index, and calibration plot supported the better predictive capacity of the nomogram over others. Treatment with metformin significantly positively affected the expression of four out of ten genes; this was beneficial to longer overall survival. The results provide a new insight into accurate prognostic prediction, as well as understanding the carcinogenesis and process of HCC .

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Section: Discussionmentioning

confidence: 99%

A Novel Nomogram Based on Lipid Metabolism-Related Risk Gene Expression Can Better Predict Overall Survival for Hepatocellular Carcinoma

Lu¹,

Hu²,

Zeng³

et al. 2021

Preprint

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“…As the target gene of miR-132-3p, UCP2 can regulate the differentiation of sheep precursor fat cells [31]. SOCS2 can also act as a regulator of adipocyte size [32]. However, there are still many DEMs whose functions are unknown, and whether they are related to lipid deposition still needs further research.…”

Section: Discussionmentioning

confidence: 99%

Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep

Han

Liu

et al. 2020

Preprint

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Background: Intramuscular fat (IMF) content has become one of the most important indicators for measuring meat quality, and levels of IMF are affected by various genes. Long non-coding RNAs (lncRNAs) are widely expressed non-coding RNAs that play an important regulatory role in a variety of biological processes; however, research on the lncRNAs involved in sheep IMF deposition is still in its infancy. Aohan fine-wool sheep (AFWS), one of China's most important meat-hair, dual-purpose sheep breed, provides a great model for studying the role of lncRNAs in the regulation of IMF deposition. We identified lncRNAs by RNA sequencing in Longissimus thoracis et lumborum (LTL) samples of sheep at two ages: 2 months (Mth-2) and 12 months (Mth-12). Results: We identified a total of 26,247 genes and 6,935 novel lncRNAs in LTL samples of sheep. Among these, 199 mRNAs and 61 lncRNAs were differentially expressed. We then compared the structural characteristics of lncRNAs and mRNAs. We obtained target genes of differentially expressed lncRNAs (DELs) and performed enrichment analyses using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). We found that target mRNAs were enriched in metabolic processes and developmental pathways. One pathway was significantly enriched, namely tight junction. Based on the analysis of critical target genes, we obtained seven candidate lncRNAs that potentially regulated lipid deposition and constructed a lncRNA-mRNA co-expression network that included MSTRG.4051.3-FZD4, MSTRG.16157.3-ULK1, MSTRG.21053.3-PAQR3, MSTRG.19941.2-TPI1, MSTRG.12864.1-FHL1, MSTRG.2469.2-EXOC6 and MSTRG.21381.1-NCOA1. We speculated that these candidate lncRNAs might play a role by regulating the expression of target genes. We randomly selected five mRNAs and five lncRNAs to verify the accuracy of the sequencing data by qRT-PCR.Conclusions: Our study identified the differentially expressed mRNAs and lncRNAs during intramuscular lipid deposition in Aohan fine-wool sheep. The work may widen the knowledge about the annotation of the sheep genome and provide a working basis for investigating intramuscular fat deposition in sheep.

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“…A marker-derived gene network reveals CAPN6 can regulate intramuscular fat deposition of beef cattle as modulators of carcass and meat quality traits [31]. SOCS2 can also act as a regulator of adipocyte size [32]. FOSB, SCD, CMYA5 was highly expressed at Mth-12.…”

Section: Identi Cation Of Differentially Expressed Mrnas and Lncrnasmentioning

confidence: 99%

Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep

Han

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Intramuscular fat (IMF) content has become one of the most important indicators for measuring meat quality, and levels of IMF are affected by various genes. Long non-coding RNAs (lncRNAs) are widely expressed non-coding RNAs that play an important regulatory role in a variety of biological processes; however, research on the lncRNAs involved in sheep IMF deposition is still in its infancy. Aohan fine-wool sheep (AFWS), one of China's most important meat-hair, dual-purpose sheep breed, provides a great model for studying the role of lncRNAs in the regulation of IMF deposition. We identified lncRNAs by RNA sequencing in Longissimus thoracis et lumborum (LTL) samples of sheep at two ages: 2 months (Mth-2) and 12 months (Mth-12). Results: We identified a total of 26,247 genes and 6,935 novel lncRNAs in LTL samples of sheep. Among these, 199 mRNAs and 61 lncRNAs were differentially expressed. We then compared the structural characteristics of lncRNAs and mRNAs. We obtained target genes of differentially expressed lncRNAs (DELs) and performed enrichment analyses using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). We found that target mRNAs were enriched in metabolic processes and developmental pathways. Three pathways were significantly enriched, namely tight junction, glycosaminoglycan biosynthesis-heparan sulfate/heparin and lysosome. Based on the analysis of critical target genes, we obtained seven candidate lncRNAs that potentially regulated lipid deposition and constructed an lncRNA-mRNA co-expression network that included MSTRG.4051.3-FZD4,MSTRG.16157.3-ULK1, MSTRG.21053.3-PAQR3, MSTRG.19941.2-TPI1, MSTRG.12864.1-FHL1,MSTRG.2469.2-EXOC6 and MSTRG.21381.1-NCOA1. We speculated that these candidate lncRNAs might play a role by regulating the expression of target genes. We randomly selected five mRNAs and five lncRNAs to verify the accuracy of the sequencing data by qRT-PCR. Conclusions: Our study provided a list of the lncRNAs and mRNAs related to intramuscular lipid deposition in sheep and laid a foundation for future research on regulatory mechanisms.

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SOCS2 modulates adipose tissue inflammation and expansion in mice

Cited by 26 publications

References 48 publications

A Novel Nomogram Based on Lipid Metabolism-Related Risk Gene Expression Can Better Predict Overall Survival for Hepatocellular Carcinoma

A Novel Nomogram Based on Lipid Metabolism-Related Risk Gene Expression Can Better Predict Overall Survival for Hepatocellular Carcinoma

Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep

Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep

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