SOD2 V16A SNP in the Mitochondrial Targeting Sequence is Associated with Noise Induced Hearing Loss in Chinese Workers

Liu, Yimin; Li, Xudong; Guo, Xiaoyu; Liu, Bin; Lin, Aihua; Ding, Yuanlin; Rao, Shaoqi

doi:10.1155/2010/753073

Cited by 33 publications

(26 citation statements)

References 39 publications

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“…51 ). Notably, allelic variations in SOD2, CAT, and PON2 have been associated with hearing loss from noise in industrial workers in candidate gene studies 52–54 . Genetic studies of late-onset hearing loss in humans is complicated by the interplay between human genetic diversity and the many decades of experience that characterize the human lifespan.…”

Section: Discussionmentioning

confidence: 99%

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Gilels

Paquette

Beaulac

et al. 2017

Sci Rep

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Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies. SEM reveals persistent damage to some surviving outer hair cell stereocilia. However, DPOAE analysis reveals that some function is preserved in low frequency outer hair cells, despite concomitant profound hearing loss. Inner hair cells, auditory synapses and spiral ganglion neurons are all present after noise exposure in the Foxo3KO/KO fourteen days post noise (DPN). We also report anti-Foxo3 immunofluorescence in adult human outer hair cells. Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage. An additional role for Foxo3 in preserving hearing is likely, as low frequency auditory function is absent in noise exposed Foxo3KO/KOs even though all cells and structures are present.

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Section: Discussionmentioning

confidence: 99%

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Gilels

Paquette

Beaulac

et al. 2017

Sci Rep

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show abstract

“…One study was based on a screen of 200 participants in Taiwan 83 . The other took audiometric data from 2400 Han Chinese workers and compared the genotypes of the 10% most susceptible and the 10% most resistant individuals 84 .…”

Section: Human Studiesmentioning

confidence: 99%

Emerging therapeutic interventions against noise-induced hearing loss

Sha

Schacht

2016

Expert Opinion on Investigational Drugs

106

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Introduction Noise-induced hearing loss (NIHL) due to industrial, military, and recreational noise exposure is a major, but also potentially preventable cause of acquired hearing loss. For the United States it is estimated that 26 million people (15% of the population) between the ages of 20 and 69 have a high-frequency NIHL at a detriment to the quality of life of the affected individuals and great economic cost to society. Areas covered This review outlines the pathology and pathophysiology of hearing loss as seen in humans and animal models. Results from molecular studies are presented that have provided the basis for therapeutic strategies successfully applied to animals. Several compounds emerging from these studies (mostly antioxidants) are now being tested in field trials. Expert opinion Although no clinically applicable intervention has been approved yet, recent trials are encouraging. In order to maximize protective therapies, future work needs to apply stringent criteria for noise exposure and outcome parameters. Attention needs to be paid not only to permanent NIHL due to death of sensory cells but also to temporary effects that may show delayed consequences. Existing results combined with the search for efficacious new therapies should establish a viable treatment within a decade.

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“…In fact, the workers with GST null genotypes had previously been shown to be more sensitive to noise-induced TTS during a daily shift [93]. Polymorphisms in superoxide dismutase (SOD)2 likewise appeared to influence responses to noise in a Taiwanese population [94], and single nucleotide polymorphisms in SODs were associated with NIHL in Chinese workers [95]. Additionally, polymorphisms of HSP 70 enhanced susceptibility to NIHL [96].…”

Section: Clinical and Military Trials In Humansmentioning

confidence: 99%

Emerging treatments for noise-induced hearing loss

Oishi¹,

Schacht²

2011

Expert Opinion on Emerging Drugs

161

118

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Introduction Approximately 5% of the population worldwide suffer from industrial, military, or recreational noise-induced hearing loss (NIHL) at great economic cost and detriment to the quality of life of affected individuals. This review discusses pharmacological strategies to attenuate NIHL that have been developed in animal models and that are now beginning to be tested in field trials. Areas covered The review describes the epidemiology, pathology and pathophysiology of NIHL in experimental animals and human. The underlying molecular mechanisms of damage are then discussed as a basis for therapeutic approaches to ameliorate the loss of auditory function. Finally, studies in military, industrial, and recreational settings are evaluated. Literature was searched employing the terms “noise-induced hearing loss” and “noise trauma”. Expert opinion NIHL, in principle, can be prevented. With the current pace of development, oral drugs to protect against NIHL should be available within the next 5 to 10 years. Positive results from ongoing trials combined with additional laboratory tests might accelerate the time from the bench to clinical treatment.

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SOD2 V16A SNP in the Mitochondrial Targeting Sequence is Associated with Noise Induced Hearing Loss in Chinese Workers

Cited by 33 publications

References 39 publications

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Emerging therapeutic interventions against noise-induced hearing loss

Emerging treatments for noise-induced hearing loss

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