Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Obireddy, Sreekanth Reddy; Subha, M. C. S.; Jithendra, T.; Madhavi, C.; Rao, K. Chowdoji; Mallikarjuna, B.

doi:10.22159/ijap.2019v11i5.34254

Cited by 21 publications

(29 citation statements)

References 27 publications

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“…Sodium alginate (SA) is natural, an anionic linear polysaccharide when it combines with water it forms a gluey gum. This biopolymer is made up of linear unbranched copolymers that contain alternating blocks of (1-4)-linked β-D-mannuronic acid (M) and (1-4)-linked α-Lglucuronic acid (G) residues 12 . Alginates are considered biocompatible, biodegradable, chemical versatility and non-toxicity for medical applications.…”

Section: Ijpsr (2020) Volume 11 Issue 3 (Research Article)mentioning

confidence: 99%

“…Mt/Mα = kt n ................. (12) Where Mt and Mα are the cumulative amount of CT released at time t and equilibrium time, respectively, k is a kinetic constant relating to the hydrogel system, and n is the diffusional exponent which suggests the nature of the release mechanism. The n values are determined from the slope of the plot of ln (Mt/Mα) versus lnt.…”

Section: Korsmeyer-peppas Modelmentioning

confidence: 99%

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2020

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In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N'methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe 2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), Field emission scanning electron microscopy (FESEM) Energydispersive X-ray spectra (EDS) and X-ray diffraction measurements (X-RD). DSC and X-RD studies reveal the molecular dispersion of Chlorthalidone (CT) drugs. Swelling and drug release behaviors of these beads were investigated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.0) at 37 ºC. Results illustrated that both the swelling and degradation of the optimized beads were influenced by the pH of the test medium, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into the Korsmeyer-Peppas equation.

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Section: Ijpsr (2020) Volume 11 Issue 3 (Research Article)mentioning

confidence: 99%

Section: Korsmeyer-peppas Modelmentioning

confidence: 99%

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“…From the last few decades, clay minerals are used in solid and semisolid pharmaceutical preparations for topical and oral administration, as well as cosmetic formulations [7,8]. Kaolin is a hydrated two-dimensional (2D) aluminosilicate clay mineral, used as active ingredients due to their uninjured bioactivity and therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Nano Clay Intercalated Polymeric Microbeads for Controlled Release of Curcumin

2021

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Objective: The objective of this study was to formulate and evaluate the Curcumin (CUR) encapsulated sodium alginate (SA)/badam gum (BG)/kaolin (KA) microbeads for controlled drug release studies. Methods: The fabricated microbeads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), and scanning electron microscopy (SEM). Dynamic swelling studies and in vitro release kinetics were performed in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results: FTIR confirms the formation of microbeads. DSC studies confirm the polymorphism of CUR in drug loaded microbeads which indicate the molecular level dispersion of the drug in the microbeads. SEM studies confirmed the microbeads are spherical in shape with wrinkled and rough surfaces. XRD studies reveal the molecular dispersion of CUR and the presence of KA in the developed microbeads. In vitro release studies and swelling studies depend on the pH of test media, which might be suitable for intestinal drug delivery. The % of drug release values fit into the Korsmeyer-Peppas equation and n values are obtained in the range of 0.577-0.664, which indicates that the developed microbeads follow the non-Fickian diffusion drug release mechanism. Conclusion: The results concluded that the CUR encapsulated microbeads are potentially good carriers for controlled drug release studies.

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“…Sodium alginate (SA) is anionic polysaccharide, composed of two different kinds of hexuronic acid residues such as β-D-mannuronic acid (M) and α-L-guluronic acid (G) arranged as random or in an alternating manner [5,7]. It has several biomedical and biotechnological applications due to its specific properties such as hydrophilicity, biodegradability, biocompatibility and non-toxicity [8][9][10] Poly(vinylpyrrolidone)-co-vinyl acetate (PVP-co-VAc) is a water soluble block copolymer consisting of both hydrophobic and hydrophilic components in its structure, which facilitates the increased solubilisation of drugs [11].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Drug Delivery System for Controlled Release of Curcumin, Intercalated With Magnetite Nanoparticles Through Sodium Alginate/Polyvinylpyrrolidone-Co-Vinyl Acetate Semi Ipn Microbeads

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Objective: The aim of the present work is to fabricate curcumin (CUR) encapsulated microbeads in the polymer matrix of sodium alginate (SA)/poly(vinylpyrrolidone)-co-vinyl acetate (PVP-co-VAc) intercalated with magnetite nanoparticles (MNPs) using glutaraldehyde (GA)/calcium chloride CaCl2 as the crosslinker. Methods: Magnetite nanoparticles (MNPs) were synthesized by a modified co-precipitation method. Curcumin encapsulated SA/PVP-co-VAc microbeads, intercalated with MNPs were prepared by simple ionotropic gelation technique. The formation of microbeads and uniform distribution of curcumin were characterized using spectroscopic methods. In addition, swelling and drug release kinetic studies of the microbeads were performed in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results: Microbeads formation was confirmed by Fourier Transform Infrared (FTIR). Differential Scanning Calorimetry (DSC) studies reveal that the peak at 181 °C of CUR was not observed in CUR loaded microbeads, which confirms that CUR was encapsulated at the molecular level in the polymer matrix. The X-Ray diffraction (X-RD) diffractograms of CUR shows 2Ө peaks between 12-28 °, which indicated the crystalline nature of CUR, these peaks are not found in CUR loaded microbeads, suggesting that the drug has been molecularly dispersed in the polymer matrix. The X-RD 2Ө peaks of MNPs are observed in the MNPs loaded microbeads, which confirms that MNPs are successfully loaded in the microbeads. The swelling studies and in vitro release studies were performed at pH 1.2 and 7.4. The results reveal that at pH 7.4 highest swelling and release was observed, which confirms that the developed microbeads are pH sensitive and are suitable for intestinal drug delivery. The drug release kinetics fit into the Korsmeyer-Peppas equation, indicating non-Fickian diffusion. Conclusion: The results concluded that the present system as dependent on pH of the test medium and hence suggest suitability for intestinal drug delivery.

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Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Cited by 21 publications

References 27 publications

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Fabrication of Nano Clay Intercalated Polymeric Microbeads for Controlled Release of Curcumin

Fabrication of Drug Delivery System for Controlled Release of Curcumin, Intercalated With Magnetite Nanoparticles Through Sodium Alginate/Polyvinylpyrrolidone-Co-Vinyl Acetate Semi Ipn Microbeads

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