Sodium Alginate Oligosaccharides Attenuate Hypertension and Associated Kidney Damage in Dahl Salt-Sensitive Rats Fed a High-Salt Diet

Terakado, Shouko; Ueno, Mai; Tamura, Yukie; Toda, Natsuko; Yoshinaga, Mariko; Otsuka, Kie; Numabe, Atsushi; Kawabata, Yusuke; Murota, Itsuki; Sato, Nobuyuki; Uehara, Yoshio

doi:10.3109/10641963.2011.618196

Cited by 34 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies on antihypertensive effects of low molecular weight sodium AOS (degree of polymerization: 2 and 3, quantities ingested: 4% or 8% w/w (diet)) suggest that the oral administration of enzymatically degraded AOS attenuates salt-induced hypertension in Dahl salt-sensitive (Dahl S) rats in a dose-dependent fashion. The reduction in blood pressure is associated with a decrease in cardiovascular and renal damage [23]. Moreover, the antihypertensive effect of high-dose sodium alginate (quantities ingested: 8% w/w (diet) was comparable to that achieved by clinically used drugs, the diuretic indapamide, or the calcium channel blocker benidipine [137].…”

Section: Antihypertensive Activitymentioning

confidence: 95%

See 1 more Smart Citation

Advances in Research on the Bioactivity of Alginate Oligosaccharides

et al. 2020

View full text Add to dashboard Cite

Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS is closely related to the diversity of their structures. AOS with a specific structure and distinct applications can be obtained by different methods of alginate degradation. This review focuses on recent advances in the biological activity of alginate and its derivatives, including their anti-tumor, anti-oxidative, immunoregulatory, anti-inflammatory, neuroprotective, antibacterial, hypolipidemic, antihypertensive, and hypoglycemic properties, as well as the ability to suppress obesity and promote cell proliferation and regulate plant growth. We hope that this review will provide theoretical basis and inspiration for the high-value research developments and utilization of AOS-related products.2 of 26 the 4 C 1 conformation and are linked by β-1,4-glycosidic bond, while in pG, all G residues are in the 1 C 4 conformation and are linked by an α-1,4-glycosidic bond. These features are responsible for the differences in their higher-order structure. For example, pG exhibits an egg-box-like conformation and usually forms stiffer 2-fold screw helical chains when dissolved in water, while pM forms belt chains through intra-molecular hydrogen bonds. Due to these dissimilarities, pM and pG, as well as their derivatives, will exhibit different activities [12].As the most abundant marine biomass and low-cost material, alginate has been extensively used in the food and medical industries. The widespread utilization is also driven by its favorable chemical properties and versatile activities. However, the applications of alginate have been greatly limited due to its high molecular weight and low bioavailability. Therefore, the degradation of high molecular weight polysaccharides into low molecular weight poly-or oligosaccharides is considered of great significance for improving their bioavailability, increasing the body's absorption of drugs, and fully utilizing the efficacy of polysaccharides. Recently, the degradation products of alginate, i.e., alginate oligosaccharides (AOS), have attracted increasing attention due to their biological activities and excellent solubility in water [13]. AOS can be depolymerized by different degradation methods, including enzymatic degradation, acid hydrolysis, and oxidative degradation [14]. Alginate lyases have been isolated from a wide range of organisms, including algae, marine invertebrates, and marine and terrestrial microorganisms, which can degrade alginate into unsaturated oligosaccharides by β-elimination [15,16]. Moreover, due to differences in degradation patterns, G content (G/M ratio), molecular weight, and spatial conformation of degradation products, AOS possess a variety of biological activities. They have anti-tumor properties [17], counteract oxidation [8], regulate immune respo...

show abstract

Section: Antihypertensive Activitymentioning

confidence: 95%

“…A growing body of evidence shows unequivocally that alginate and AOS possess antihypertensive effects [23,24]. At least two mechanisms by which these compounds lower blood pressure have been proposed: (i) suppression of the absorption of salt in the intestine, and (ii) direct vasodilatory effect [134].…”

Section: Antihypertensive Activitymentioning

confidence: 99%

Advances in Research on the Bioactivity of Alginate Oligosaccharides

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Terakado et al. () further established AOS protective effects in high‐salt diet fed Dahl salt‐sensitive (Dahl S) rat. When treated with enzymatically produced AOS (4% or 8% w/w) for 7 weeks, hypertensive glomerular sclerosis and arterial injury in the kidney of salt‐induced hypertensive Dahl S rat were significantly attenuated.…”

Section: Health Beneficial Effects and Potential Aos Applicationsmentioning

confidence: 99%

Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

Liu

Yang

et al. 2019

Comp Rev Food Sci Food Safe

224

121

View full text Add to dashboard Cite

Alginate, a group of polyuronic saccharides, has been widely used in both pharmaceutical and food industries due to its unique physicochemical properties as well as beneficial health effects. However, the potential applications of alginate are restricted because of its low water solubility and high solution viscosity when significant concentrations are needed, particularly in food products. Alginate oligosaccharides (AOS), oligomers containing 2 to 25 monomers, can be obtained via hydrolysis of glycosidic bonds, organic synthesis, or through biosynthesis. Generally, AOS have shorter chain lengths and thus improved water solubility when compared with higher molecular weight alginates of the same monomers. These oligosaccharides have attracted interest from both basic and applied researchers. AOS have unique bioactivity and can impart health benefits. They have shown immunomodulatory, antimicrobial, antioxidant, prebiotic, antihypertensive, antidiabetic, antitumor, anticoagulant, and other activities. As examples, they have been utilized as prebiotics, feed supplements for aquaculture, poultry, and swine, elicitors for plants and microorganisms, cryoprotectors for frozen foods, and postharvest treatments. This review comprehensively covers methods for AOS production from alginate, such as physical/chemical methods, enzymatic methods, fermentation, organic synthesis, and biosynthesis. Moreover, current progress in structural characterization, potential health benefits, and AOS metabolism after ingestion are summarized in this review. This review will discuss methods for producing and modified AOS with desirable structures that are suited for novel applications.

show abstract

“…Wakame significantly reduced both systolic and diastolic BP. The antihypertensive effect exerted by this alga was ascribed to its content in alginates, a polysaccharide that has shown preventive effects in experimental models of hypertension in rats, in addition to their beneficial impact on cholesterol and diabetes mellitus [35,36]. Several studies have described that bioactive peptides and protein hydrolysates from seaweeds have antihypertensive properties [6,37,38], such as those from Undaria pinnatifida [39,40,41], Palmaria palmata [42,43,44], Porphyra columbina [45,46], Porphyra yezoensis [47,48], among others.…”

Section: Hypertensionmentioning

confidence: 99%

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

et al. 2018

View full text Add to dashboard Cite

The beneficial effects of various polyphenols with plant origins on different cardiovascular-associated disorders, such as hypertension, diabetes mellitus type 2 and metabolic syndrome are well known. Recently, marine crude-drugs are emerging as potential treatments in many noncommunicable conditions, including those involving the cardiovascular system. Among the active compounds responsible for these activities, seaweed polyphenols seem to play a key role. The aim of the present review is to summarise the current knowledge about the beneficial effects reported for edible seaweed polyphenols in the amelioration of these prevalent conditions, focusing on both preclinical and clinical studies. This review will help to establish the basis for future studies in this promising field.

show abstract

Sodium Alginate Oligosaccharides Attenuate Hypertension and Associated Kidney Damage in Dahl Salt-Sensitive Rats Fed a High-Salt Diet

Abstract: The results of this study suggest that sodium alginate oligosaccharides attenuate salt-induced hypertension in Dahl S rats. This reduction is associated with decreases in cardiovascular and renal damage.

Cited by 34 publications

References 9 publications

Advances in Research on the Bioactivity of Alginate Oligosaccharides

Advances in Research on the Bioactivity of Alginate Oligosaccharides

Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

Contact Info

Product

Resources

About