Sodium alginate-polyethylene glycol paste loaded with zinc-doped tricalcium phosphate particles for the treatment of dentin hypersensitivity

Huang, Hao; Fan, Minjie; Yang, Anchun; Chang, Dongbiao; Li, Jinsheng; Yang, Liwen; Li, Xinlun; Wang, Mengyuan; Zheng, Pengfei; Guo, Tailin; Weng, Jie

doi:10.1016/j.apmt.2024.102171

Applied Materials Today

2024

DOI: 10.1016/j.apmt.2024.102171

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Sodium alginate-polyethylene glycol paste loaded with zinc-doped tricalcium phosphate particles for the treatment of dentin hypersensitivity

Hao Huang,

Minjie Fan,

Anchun Yang

et al.

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Cited by 2 publications

References 72 publications

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MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing

Dai,

Jiang,

Liu

et al. 2024

Regenerative Biomaterials

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Poor wound healing in diabetics is primarily caused by persistently high levels of inflammation and recurrent bacterial infections. The catalytic therapy technique based on nanozyme medicine has emerged as a beacon of hope for patients with diabetic wounds. However, the use of a single-atom nanozyme may still have limitations, including nanozyme burst release, immunological clearance, and insufficient antibacterial activity. To address the aforementioned problems, we provide a new nano-catalytic therapeutic agent for diabetic skin ulcers that incorporates a single-atom nanozyme with high antioxidant activity into a metal-organic framework (ZIF-Cu/C-dots). First, a Cu single-atom nanozyme supported by ultra-small carbon dots (Cu/C-dots) with high antioxidant activity was created. A nanozyme-integrated metal-organic framework was then created, utilizing Cu/C-dots as ligands and Zn2+ as the core metal. Cu/C-dots have good oxidase-like activity, shielding the biological system from ROS damage and reducing the expression of TNF-α and IL-1β. Zn2+ also has good antibacterial activity (the antibacterial rate was more than 90%). This integrated technique prevents nanozyme aggregation, improves nanozyme biocompatibility, slows down the breakdown of ZIF, and allows for the regulated release of Cu/C-dots and Zn2+ as needed. Finally, in vivo studies have shown that ZIF-Cu/C-dots can effectively alleviate inflammation at the site of diabetic wounds, accelerate vascular regeneration, promote collagen deposition, and enhance tissue remodeling, serving as a novel nano-catalytic platform for the treatment of wounds that are difficult to heal.

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MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing

Dai,

Jiang,

Liu

et al. 2024

Regenerative Biomaterials

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Preparation of Time-Sequential Functionalized ZnS-ZnO Film for Modulation of Interfacial Behavior of Metals in Biological Service Environments

Zhang,

Tang,

Gao

et al. 2024

Biomolecules

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Blood-contact devices are prone to inflammation, endothelial dysfunction, coagulation, and the uncontrolled release of metal ions during implantation and service. Therefore, it is essential to make these multifunctional. Herein, a superhydrophobic DE@ZnS-ZnO@SA film (composed of dabigatran ester, zinc sulfite, zinc oxide, and stearic acid, respectively) is produced. The prepared film has non-adhesion and antibacterial properties, superior mechanical stability, durability, corrosion resistance, and is self-cleaning and blood-repellent. The results of the hemolysis, cytotoxicity, and other anticoagulant experiments revealed that the film had good blood compatibility, no cytotoxicity, and excellent anticoagulant properties. The film displays anticoagulant properties even after being immersed in Phosphate-Buffered Saline (PBS) for 7 days. Furthermore, the film can spontaneously release H2S gas for 90 h after soaking in an acidic environment (pH = 6) for 90 h. This property improves the acidic microenvironment of the lesion and promotes the proliferation of endothelial cells by using H2S gas. In addition, the film can inhibit the uncontrollable release of Zn2+ ions, avoiding its toxicity even when immersed in an acid environment for 35 days. This time-sequential functionalized surface has the potential to typify the future of blood-contacting scaffolds for long-lasting use.

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Sodium alginate-polyethylene glycol paste loaded with zinc-doped tricalcium phosphate particles for the treatment of dentin hypersensitivity

Cited by 2 publications

References 72 publications

MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing

MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing

Preparation of Time-Sequential Functionalized ZnS-ZnO Film for Modulation of Interfacial Behavior of Metals in Biological Service Environments

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