Sodium ascorbyl phosphate in topical microemulsions

Špiclin, Polona; Homar, Miha; Zupančič-Valant, Andreja; Gašperlin, Mirjana

doi:10.1016/s0378-5173(03)00063-2

Cited by 113 publications

(64 citation statements)

References 13 publications

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“…[7][8][9][10] Outros métodos mais comuns, como a condutividade iônica, medidas reológicas, espectroscopia de fotocorrelação, microscopia de luz polarizada, entre outros, também são freqüentemente utilizados para o estudo do comportamento físico-químico interno de tais sistemas. 11,12 A microscopia de luz polarizada é uma ferramenta vital para a identificação dos materiais líquido-cristalinos. Sob um plano de luz polarizada, uma substância pode ser classificada como anisotrópica ou isotrópica.…”

Section: 45unclassified

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Chorilli¹,

Prestes²,

Rigon³

et al. 2009

Quím. Nova

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Recebido em 16/1/08; aceito em 22/9/08; publicado na web em 15/4/09 DEVELOPMENT OF LIQUID-CRYSTALLINE SYSTEMS USING SILICON GLYCOL COPOLYMER AND POLYETHER FUNCTIONAL SILOXANE. For the construction of the phase diagrams, the method of the aqueous titration was used. There were prepared 5 ternary diagrams, varying the surfactant and the oil phase. The liquid-crystalline phases were identified by polarized light microscopy. The formulations prepared with silicon glycol copolymer, polyether functional siloxane (PFS) and water (S 1 ) and with diisopropyl adipate, PFS and water (S 4 ) presented liquid-crystalline phases with lamellar arrangement. Moreover, after 15 days in hot oven (37 o C), the formulations presented hexagonal arrangement, evidencing the influence of the temperature in the organization of the system.

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Section: 45unclassified

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Chorilli¹,

Prestes²,

Rigon³

et al. 2009

Quím. Nova

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“…The samples were withdrawn on 0, 15 and 30 days of storage condition and evaluated for pH, drug content and in-vitro drug permeation study. 20 was characterized for pH, viscosity, percent drug content, spreadability and in-vitro diffusion study.…”

Section: 21mentioning

confidence: 99%

Enhancement of Percutaneous Delivery of Dapsone by Microemulsion Gel

Mahore¹,

Suryawanshi²,

Shirolkar³

et al. 2017

JYP

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Objective: The purpose of this study was to developed microemulsion based gel formulation for topical delivery of dapsone with an objective to increase the solubility and skin permeability of the drug for treatment of acne. Methodology: The solubility of dapsone in oils, surfactants and cosurfactants was evaluated by saturation solubility to screen the components of the microemulsion. The pseudoternary phase diagrams were constructed using capryol 90 and N-methyl-2 pyrrolidone as the oil phase, Kolliphor EL as surfactant and PEG 400 as the co-surfactant. The system were assessed for drug-loading efficiency and characterized for pH, conductance, viscosity, particle size, drug content, globule size, zeta potential and drug release. Optimized formulation systems were formulated into gel form by using poloxamer-407 and evaluated for viscosity, spreadability, drug content, stability, in-vitro skin permeation, steady state flux, permeability coefficient, enhancement ration and skin irritation study. Result and Discussion: Globule size of optimized microemulsion (F2) was found to be 27.53 nm, zeta potential was found to be-14.6 mV, permeability of drug from microemulsion within 8h was observed 82%, In-vitro diffusion study showed increase in flux of microemulsion based gel (392.43 µg cm-2 h-1) to that of simple dapsone gel (274.4 ± 0.78 µg cm-2h-1). Draize test revealed absence of irritation and inflammation on rat skin. Conclusion: Microemulsion based gel of dapsone formulation provided better application property and stability in comparison to simple gel. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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“…Franz diffusion apparatus having an effective diffusion [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] area of 3.14 cm 2 receptor volume was 20 ml were employed for the permeation study. The optimized skin was placed at 25 o C for 30 minutes before conducting the experiment.…”

Section: Permeation Retention Studiesmentioning

confidence: 99%

Design Development and Evaluation of Topical Microemulsion

Muzaffar¹,

Singh²

2017

Int. Res. J. Pharm.

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A microemulsion based gel was designed for the topical and targeted delivery of sertaconazole nitrate for the treatment of su perficial fungal infection. The microemulsion region was obtained using a ternary diagram, different ratio of oil and Smix were used. The microemulsion of sertaconazole containing 2% (w/w) of sertaconazole, 6.67% (w/w) of oil phase (Eugenol+Oleic acid 1:1), 60.18% (w/w) of surfactant mixture 2:1 ratio (Tween-80 and Transcutol-P) and 33.15% (w/w) with distilled water. The prepared microemulsion gel and commercial cream of sertaconazole were evaluated for in-vitro and ex-vivo studies. The highest drug retention was achieved with Tween 80 and Transcutol P (T80TC45) when the optimized formulation was converted to a gel. The designed formulation MG2 was safe to be used over the skin as the PDI=0 when compared with commercial cream and MG1. The optimized formulation also posse's anti-inflammatory activity. The average zone of inhibition of MG2 was (23.19 ± 0.478) which was more than the commercial cream (15.34 ± 0.382) or MG1 (17.78 ± 0.715). Candida albicans which may be due to better permeation and retention effect of microemulsion gel 2. The MG2 was found to be stable after six month. The results obtained in this research from in vitro and in vivo data it can be concluded that the developed microemulsions have great potential for topical drug delivery in the treatment of inflammation and fungal infection.

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Sodium ascorbyl phosphate in topical microemulsions

Cited by 113 publications

References 13 publications

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Enhancement of Percutaneous Delivery of Dapsone by Microemulsion Gel

Design Development and Evaluation of Topical Microemulsion

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