Sodium bicarbonate induces alkalosis, but improves high-intensity cycling performance only when participants expect a beneficial effect: a placebo and nocebo study

Zagatto, Alessandro Moura; Lopes, Vithor Hugo Fialho; Dutra, Yago Medeiros; de Poli, Rodrigo Araujo Bonetti; Dolan, Eimear; Rasica, Letizia; Murias, Juan M.; de Azevedo, Paulo Henrique Silva Marques

doi:10.1007/s00421-023-05368-0

Eur J Appl Physiol

2023

DOI: 10.1007/s00421-023-05368-0

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Sodium bicarbonate induces alkalosis, but improves high-intensity cycling performance only when participants expect a beneficial effect: a placebo and nocebo study

Alessandro Moura Zagatto,

Vithor Hugo Fialho Lopes,

Yago Medeiros Dutra

et al.

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2024

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Caffeine supplementation does not enhance jump performance: a placebo and nocebo study

Sousa,

Azevedo,

Azevedo

et al. 2024

Preprint

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Purpose: There is evidence that caffeine supplementation improves jump performance in studies where the design is randomized, counterbalanced and placebo-controlled. However, there is recent evidence that this outcome is expectation-dependent. Here, we applied a method to nullify the expectancy. Therefore, we aimed to check whether caffeine supplementation improves jump performance when nullifying the positive expectation for performance improvement. Methods: Thirty-four women participated. Participants performed squat jump and countermovement jump in four days. The first day was a control day. In the last three days, we gave the participants caffeine (6 mg. kg-1). However, we informed them that randomly and blindly, participants would receive caffeine (ergogenic), placebo (ineffective) or lactic acid (ergolytic). Results: Jump performance neither improves along the days (P>0.05) nor through different expectations (P>0.05). Still, there is a moderate chance (>75%) to observe similar performance between control and supplementation days or different expectancies. Conclusion: We conclude that caffeine supplementation does not improve jump performance in women when positive expectation is nullified.

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Caffeine supplementation does not enhance jump performance: a placebo and nocebo study

Sousa,

Azevedo,

Azevedo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Sodium bicarbonate induces alkalosis, but improves high-intensity cycling performance only when participants expect a beneficial effect: a placebo and nocebo study

Cited by 1 publication

References 43 publications

Caffeine supplementation does not enhance jump performance: a placebo and nocebo study

Caffeine supplementation does not enhance jump performance: a placebo and nocebo study

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