Sodium Bicarbonate Solution versus Chlorhexidine Mouthwash in Oral Care of Acute Leukemia Patients Undergoing Induction Chemotherapy: A Randomized Controlled Trial

Choi, So Eun; Kim, Hee Seung

doi:10.1016/j.anr.2012.05.004

Cited by 40 publications

(38 citation statements)

References 32 publications

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“…Given its ability to affect the innate immune response, a known stimulator of the mucositis pathway, the oral microflora could serve to exacerbate or extend mucositis (Laheij and de Soet 2014;Stringer and Logan 2015). Because the pain associated with OM likely affects patients' ability to perform conventional oral hygiene procedures, supplemental antibacterial oral rinses such as chlorhexidine or povidone iodine have been studied in the context of OM prevention (Yoneda et al 2007;Choi and Kim 2012;McGuire et al 2013). The inconsistent results of such trials are perplexing and Figure 2.…”

Section: The Role Of the Oral Microbiota In The Putative Etiology Of Ommentioning

confidence: 99%

Host-Microbiome Cross-talk in Oral Mucositis

Vasconcelos

Sanfilippo

Paster³

et al. 2016

J Dent Res

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Oral mucositis (OM) is among the most common, painful, and debilitating toxicities of cancer regimen-related treatment, resulting in the formation of ulcers, which are susceptible to increased colonization of microorganisms. Novel discoveries in OM have focused on understanding the host-microbial interactions, because current pathways have shown that major virulence factors from microorganisms have the potential to contribute to the development of OM and may even prolong the existence of already established ulcerations, affecting tissue healing. Additional comprehensive and disciplined clinical investigation is needed to carefully characterize the relationship between the clinical trajectory of OM, the local levels of inflammatory changes (both clinical and molecular), and the ebb and flow of the oral microbiota. Answering such questions will increase our knowledge of the mechanisms engaged by the oral immune system in response to mucositis, facilitating their translation into novel therapeutic approaches. In doing so, directed clinical strategies can be developed that specifically target those times and tissues that are most susceptible to intervention.

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Section: The Role Of the Oral Microbiota In The Putative Etiology Of Ommentioning

confidence: 99%

Host-Microbiome Cross-talk in Oral Mucositis

Vasconcelos

Sanfilippo

Paster³

et al. 2016

J Dent Res

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“…Intraoral exam was used to evaluate patients of selected studies. Studies 14,16 have used microbiological tests. Pereira Pinto et al 13 also used cytological exam.…”

Section: Contentsmentioning

confidence: 99%

“…Participants' sample among selected studies has varied from 14 to 48 patients, in a total of 160 participants. Four studies were performed primarily in children between 2 and 15 years of age 16,17 . Most participants of the studies were above 15 years of age.…”

Section: Contentsmentioning

confidence: 99%

“…Pereira Pinto et al 13 also used cytological exam. Aiming at evaluating pain level of patients, authors 16,18 have used questionnaires applied to participants. Chlorhexidine gluconate concentration was 0.12%, except for the study by Mehdipour et al 17 the concentration of which was 0.2%.…”

Section: Contentsmentioning

confidence: 99%

“…At the end, articles analyzed and selected by evaluators after consensus meeting were included in this review. After initial search, 15 studies had potential to be included in this study, however after detailed and complete analysis, only 6 have met all methodological inclusion criteria [13][14][15][16][17][18] . Among selected studies, 5 were performed in developing countries [13][14][15]17,18 and one in a developed country 16 .…”

Section: Contentsmentioning

confidence: 99%

See 2 more Smart Citations

Chlorhexidine to treat oral mucositis in patients with acute leukemia: systematic review

Macedo¹,

Morais²,

Dantas³

et al. 2015

Revista Dor

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Impact of oral care intervention on quality of life of patients with oral cancer undergoing radiotherapy in Sri Lanka: A quasi‐experimental study

Kosgallana,

Jayasekara,

Abeysinghe

et al. 2024

Head & Neck

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BackgroundRadiotherapy is used to treat oral cancer, yet it negatively affects patients' health‐related quality of life (HRQOL). The aim was to evaluate the impact of an oral healthcare intervention on HRQOL of patients with oral cancer who receive radiotherapy with or without chemotherapy.MethodsAn oral healthcare intervention was provided to 41 patients with oral cancer before radiotherapy (fluoride varnish application, scaling, permanent restorations, adjustment of sharp teeth, and extraction of teeth with questionable prognosis, oral hygiene instructions), during, and 3 months after radiotherapy (baking soda mouthwash, artificial saliva spray). EORTC QLQ‐H&N35 was used to compare the HRQOL of the intervention and control groups, with the latter having received routine oral healthcare.ResultsThe intervention group showed lesser values for HRQOL domains and items indicating fewer side effects during the last week of radiotherapy and 3 months after, compared to the control group. Most of the changes in HRQOL were significantly less in the intervention group compared to the control group (p < 0.01).ConclusionThe oral healthcare intervention effectively reduced the effect of radiotherapy and positively impacted on HRQOL of patients with oral cancer.

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Sodium Bicarbonate Solution versus Chlorhexidine Mouthwash in Oral Care of Acute Leukemia Patients Undergoing Induction Chemotherapy: A Randomized Controlled Trial

Abstract: As a result of this study, it was found that oral care by SB solution for acute leukemia patients undergoing chemotherapy was an effective intervention to improve oral health.

Cited by 40 publications

References 32 publications

Host-Microbiome Cross-talk in Oral Mucositis

Host-Microbiome Cross-talk in Oral Mucositis

Chlorhexidine to treat oral mucositis in patients with acute leukemia: systematic review

Impact of oral care intervention on quality of life of patients with oral cancer undergoing radiotherapy in Sri Lanka: A quasi‐experimental study

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