Sodium bicarbonate treatment reduces renal injury, renal production of transforming growth Factor-β, and urinary transforming growth Factor-β excretion in rats with doxorubicin-induced nephropathy

Baroni, Edmara Aparecida; Costa, R. S.; Volpini, Rildo Aparecido; Coimbra, Terezila Machado

doi:10.1016/s0272-6386(99)70363-x

Cited by 32 publications

(30 citation statements)

References 37 publications

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“…This is usually observed in children treated with vincristine or very high doses of cyclophosphamide. Nephrotoxicity rarely occurs after anthracyclines (proteinuria, glomerulosclerosis, tubulointestinal fibrosis) and asparaginase [1,2,13]. However, these abnormalities were not found in our group.…”

Section: Discussioncontrasting

confidence: 60%

Renal function during and after treatment for acute lymphoblastic leukemia in children

2005

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Renal function tests (cystatin C, serum and urine creatinine, creatinine clearance, serum and urine beta(2)-microglobulin, microalbuminuria, osmolality) were performed in 21 children at the diagnosis and during the treatment for acute lymphoblastic leukemia (ALL) (group I) and in 37 children (group II) treated for ALL 3.9+/-3.7 years before the study. The results were compared to 20 healthy children. Mean values of renal tests were in normal range at all points of analysis in groups I and II compared to the control group. Transitory higher cystatin C values (but in normal range) were observed after methotrexate administration and after the end of treatment. Deteriorated renal function was observed in one child during the treatment (after each protocol) and in five children treated previously for ALL. In conclusion, combined treatment for ALL is not associated with severe or long-term impairment of renal function.

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Section: Discussioncontrasting

confidence: 60%

Renal function during and after treatment for acute lymphoblastic leukemia in children

2005

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“…This fact suggests that the renal handling of protein induced activation of the interstitial cells. It has been suggested that proteins filtered by the glomeruli could be toxic for tubule cells (27)(28)(29). Studies with tubule cell cultures have shown that some proteins such as IgG and albumin induce an increase in the production of inflammatory and vasoactive factors (27,28).…”

Section: Discussionmentioning

confidence: 99%

alpha-Smooth muscle actin and proliferating cell nuclear antigen expression in focal segmental glomerulosclerosis: functional and structural parameters of renal disease progression

Geleilete

Costa

Dantas

et al. 2001

Braz J Med Biol Res

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The aim of the present study was to investigate the expression of asmooth muscle actin (a-SM-actin) and proliferating cell nuclear antigen (PCNA) in renal cortex from patients with focal segmental glomerulosclerosis (FSGS) and their correlations with parameters of renal disease progression. We analyzed renal biopsies from 41 patients with idiopathic FSGS and from 14 control individuals. The a-SMactin immunoreaction was evaluated using a score that reflected the changes in the extent and intensity of staining in the glomerular or cortical area. The PCNA reaction was quantified by counting the labeled cells of the glomeruli or renal cortex. The results, reported as median ± percentile (25th; 75th), showed that the a-SM-actin scores in the glomeruli and tubulointerstitium from the renal cortex were 2.0 (2.0; 4.0) and 3.0 (3.0; 4.0), respectively, in patients with FSGS, and 0.5 (0.0; 1.0) and 0.0 (0.0; 0.5) in the controls. The number of PCNApositive cells per glomerulus and graded field of tubulointerstitium from the renal cortex was 0.2 (0.0; 0.4) and 1.1 (0.3; 2.2), respectively, for patients with FSGS, and 0.0 (0.0; 0.5) and 0.0 (0.0; 0.0) for controls. The present data showed an increase of a-SM-actin and PCNA expression in glomeruli and renal cortex from FSGS patients.The extent of immunoreaction for a-SM-actin in the tubulointerstitial area was correlated with the intensity of proteinuria. However, there was no correlation between the kidney expression of these proteins and the reciprocal of plasma creatinine level or renal fibrosis. These findings suggest that the immunohistochemical alterations may be reversible.

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“…Oral bicarbonate therapy sufficient to raise urine pH to Ͼ5.0, the optimum pH for alternative pathway activation, decreases complement activation in the tubular compartment in proteinuric humans (150) and rats (151). Metabolic acidosis correction also decreases protein catabolism, which may benefit proteinuric renal disease (152).…”

Section: Sodium Bicarbonate (Nahco 3 ) To Correct Metabolic Acidosis mentioning

confidence: 99%

Management of Glomerular Proteinuria

Wilmer¹,

Rovin²,

Hébert

et al. 2003

Journal of the American Society of Nephrology

189

120

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Sodium bicarbonate treatment reduces renal injury, renal production of transforming growth Factor-β, and urinary transforming growth Factor-β excretion in rats with doxorubicin-induced nephropathy

Cited by 32 publications

References 37 publications

Renal function during and after treatment for acute lymphoblastic leukemia in children

Renal function during and after treatment for acute lymphoblastic leukemia in children

alpha-Smooth muscle actin and proliferating cell nuclear antigen expression in focal segmental glomerulosclerosis: functional and structural parameters of renal disease progression

Management of Glomerular Proteinuria

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