Sodium butyrate aggravates glucose dysregulation and dyslipidemia in high fat-fed Wistar rats

Oyabambi, Adewumi Oluwafemi; Olaniyi, Kehinde S.

doi:10.1016/j.metop.2022.100226

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…Similarly, Nile tilapia-fed dietary SB showed an enhanced length of intestines, intestinal muscle thickness, and villi height, as stated by Abdel-Tawwab et al [58], Alves Jesus et al [59], and Shalata et al [60]. SB can support the activity of intestinal epithelial cells as a source of energy, leading to the proliferation of intestinal cells and restoration of mucosal damage [33]. The enhancement in the villi length led to increased absorption area and efficient feed utilization.…”

Section: Discussionmentioning

confidence: 54%

“…For this reason, the study hypothesized that adding SB may enhance the growth performance and digestion capacity of tilapia-fed T. molitor, which is evident. SB is one of the salts for butyric acid formation associated with the proliferation of intestinal epithelial cells as a source of energy [33]. Further, butyric acid can eliminate the presence of harmful bacteria and activate the reproduction of beneficial bacteria in the local intestines [31].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, it is the most recommended form of organic acids since sodium butyrate facilitates the availability of nucleotides and amino acids through the intestines [32]. Further, sodium butyrate provides sufficient energy for the intestinal epithelial cells, thereby enhancing the absorption of digested nutrients to the fish's entire body [33]. Concurrently, dietary sodium butyrate enhanced the zootechnical, feeding, and health performances of several fish species (reviewed by Fabay et al [31] and Abdel-Latif et al [29]).…”

Section: Introductionmentioning

confidence: 99%

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Improving Yellow Mealworm (Tenebrio molitor) Utilization with Sodium Butyrate in Nile Tilapia Diets: Effects on Growth Performance, Intestinal Histology, Antioxidative Response, and Blood Biomarkers

El-Desouky,

Ibrahim,

Abd El-Razek

et al. 2024

Aquaculture Nutrition

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Yellow mealworm (Tenebrio molitor) meal was introduced to aquafeed as a suitable protein source to replace fish meal (FM) and soybean meal and, thereby, consistent aquaculture production. However, mealworms should be added at adequate levels due to the presence of antinutritional factors such as chitin. Consequently, sodium butyrate (SB) is suggested to improve feed quality and ensure aquatic animals’ productivity and welfare. In this study, parallel with the protein source (T. molitor meal or FM), dietary supplementation of SB (1 g/kg) is involved as a factor in the 2 × 2 factorial study. The first and the second diets were formulated using FM as a protein source with or without SB, while the third and fourth diets were prepared by replacing FM with T. molitor meal with or without SB supplementation. After 60 days, fish fed with FM or T. molitor and SB showed improved final body weight and weight gain, while those fed with T. molitor without SB had a reduced protein efficiency ratio. Histological analysis revealed that dietary SB improved intestinal histological features by increasing the height and branching of intestinal villi and immune cell infiltration near intestinal crypts in Nile tilapia-fed FM or T. molitor. Furthermore, fish-fed FM or T. molitor and SB had higher Hb, red blood cells, PCV, total protein, and globulin levels than fish-fed respective test diets without SB supplementation. Dietary SB addition to FM or T. molitor-based diets also significantly enhanced blood lysozyme and phagocytic activities, catalase, superoxide dismutase, glutathione peroxidase, and reduced MDA levels. Our results demonstrate that T. molitor meal can replace FM without compromising Nile tilapia’s growth performance and health status. Additionally, SB supplementation improved T. molitor meal utilization by Nile tilapia, thereby significantly enhancing the growth, digestion capacity, intestinal histological features, and antioxidative and immune responses. Consequently, dietary T. molitor meal reduces the reliance on FM and improves the sustainability and efficiency of Nile tilapia production.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Improving Yellow Mealworm (Tenebrio molitor) Utilization with Sodium Butyrate in Nile Tilapia Diets: Effects on Growth Performance, Intestinal Histology, Antioxidative Response, and Blood Biomarkers

El-Desouky,

Ibrahim,

Abd El-Razek

et al. 2024

Aquaculture Nutrition

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“…In the study of Aziz et al, it was reported that Lactobacillus restored lipolytic gene expression [ 46 ]. Lactobacillus and Bifidobacterium can improve the short-chain fatty acids (SCFAs) which had been shown to improve lipid signaling [ 50 , 51 ]. Lactobacillus may affect TC levels by secreting biological inhibitors, such as cholesterol lipid coenzyme A inhibitors, to inhibit the formation of key enzymes or precursors in the cholesterol biosynthesis pathway [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis

Wang,

Zheng,

Kuang

et al. 2023

Int J Obes

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Background Probiotics are commonly used after bariatric surgery. However, uncertainty remains regarding their effects. The purpose of this systematic review was to assess the effect of probiotics in patients with morbid obesity undergoing bariatric surgery. Methods PubMed, Cochrane Library, Embase, Science Direct, and Web of Science were searched from inception to April 4, 2023. No language restrictions were applied. Relevant randomized controlled trials and controlled clinical trials were included. We used the aggregated data extracted from the trials and assessed the heterogeneity. When severe heterogeneity was detected, a random effect model was used. All stages of the review were done by independent authors. Results We screened 2024 references and included 11 randomized controlled trials and controlled clinical trials. Compared with the protocol groups, probiotics showed significant effects on regulating aspartate amino transferase level (MD = −4.32 U/L; 95% CI [−7.10, −1.53], p = 0.002), triglycerides (MD = −20.16 mg/dL; 95% CI [−34.51, −5.82], p = 0.006), weight (MD = −1.99 kg; 95% CI [−3.97, −0.01], p = 0.05), vitamin B12 (MD = 2.24 pg/dL; 95% CI [−0.02, 4.51], p = 0.05), dietary energy (MD = −151.03 kcal; 95% CI [−215.68, −86.37], p < 0.00001), dietary protein (MD = −4.48 g/day, 95% CI [−8.76, −0.20], p = 0.04), dietary carbohydrate (MD = −34.25 g/day, 95% CI [−44.87, −23.62], p < 0.00001), and dietary fiber (MD = −2.17 g/day, 95% CI [−3.21, −1.14], p < 0.0001). There were no severe side effects related to probiotics. Conclusions Our meta-analysis suggested that probiotics may delay the progression of liver function injury, improve lipid metabolism, reduce weight, and reduce food intake, although the effects on other indicators were insignificant. Probiotics may be helpful for patients undergoing bariatric surgery. The review was registered on PROSPERO (International prospective register of systematic reviews): CRD42023407970. No primary source of funding.

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Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics

Mousavi Ghahfarrokhi,

Mohamadzadeh,

Samadi

et al. 2024

Curr Nutr Rep

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Sodium butyrate aggravates glucose dysregulation and dyslipidemia in high fat-fed Wistar rats

Cited by 10 publications

References 29 publications

Improving Yellow Mealworm (Tenebrio molitor) Utilization with Sodium Butyrate in Nile Tilapia Diets: Effects on Growth Performance, Intestinal Histology, Antioxidative Response, and Blood Biomarkers

Improving Yellow Mealworm (Tenebrio molitor) Utilization with Sodium Butyrate in Nile Tilapia Diets: Effects on Growth Performance, Intestinal Histology, Antioxidative Response, and Blood Biomarkers

Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis

Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics

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