Sodium butyrate alleviates LPS-induced acute lung injury in mice via inhibiting HMGB1 release

Li, Na; Liu, Xinxin; Hong, Mei; Huang, Xinzhou; Chen, Hui; Xu, Jianxin; Wang, Chao; Zhang, Yan-xiang; Zhong, Jixin; Nie, Hao; Gong, Quan

doi:10.1016/j.intimp.2018.01.017

Cited by 51 publications

(41 citation statements)

References 25 publications

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Section: Synbioticsmentioning

confidence: 99%

“…A shift in the macrophage metabolism, shown by the reduced glycolysis and inhibition of the mechanistic target of rapamycin (mTOR) activity, accounted for the butyrate-induced antimicrobial activity of the macrophages. Similarly, the ability of sodium butyrate to alleviate acute lung injury in mice has been shown through suppression of high-mobility group box 1 (HMGB1) release and NF-κB activation [ 162 ]. While the NF-κB activation promotes the heightened expression of inflammatory mediators in response to injury and inflammation, HMGB1 participates in the downstream development of acute lung injury as a late pro-inflammatory mediator.…”

Section: Synbioticsmentioning

confidence: 99%

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Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

et al. 2020

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Viral respiratory infections (VRIs) can spread quickly and cause enormous morbidity and mortality worldwide. These events pose serious threats to public health due to time lags in developing vaccines to activate the acquired immune system. The high variability of people’s symptomatic responses to viral infections, as illustrated in the current COVID-19 pandemic, indicates the potential to moderate the severity of morbidity from VRIs. Growing evidence supports roles for probiotic bacteria (PB) and prebiotic dietary fiber (DF) and other plant nutritional bioactives in modulating immune functions. While human studies help to understand the epidemiology and immunopathology of VRIs, the chaotic nature of viral transmissions makes it difficult to undertake mechanistic study where the pre-conditioning of the metabolic and immune system could be beneficial. However, recent experimental studies have significantly enhanced our understanding of how PB and DF, along with plant bioactives, can significantly modulate innate and acquired immunity responses to VRIs. Synbiotic combinations of PB and DF potentiate increased benefits primarily through augmenting the production of short-chain fatty acids (SCFAs) such as butyrate. These and specific plant polyphenolics help to regulate immune responses to both restrain VRIs and temper the neutrophil response that can lead to acute respiratory distress syndrome (ARDS). This review highlights the current understanding of the potential impact of targeted nutritional strategies in setting a balanced immune tone for viral clearance and reinforcing homeostasis. This knowledge may guide the development of public health tactics and the application of functional foods with PB and DF components as a nutritional approach to support countering VRI morbidity.

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Section: Synbioticsmentioning

confidence: 99%

Section: Synbioticsmentioning

confidence: 99%

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

et al. 2020

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“…Because ANG II and HMGB1 can both induce macrophage polarize, we hypothesis that the HMGB1 released from macrophage may play an important role in ANG II induced macrophage polarize. Studies reported that both Ethyl pyruvate (EP) (Davé et al, ) and Sodium butyrate (SB) (Li et al, ) can inhibit the release of HMGB1. RAW 264.7 cells were pretreated with EP and SB for 1 h, followed by ANG II stimulation and Western blotting detection.…”

Section: Resultsmentioning

confidence: 99%

Angiotensin II enhances the acetylation and release of HMGB1 in RAW264.7 macrophage

Zhou

Chen

et al. 2018

Cell Biology International

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The high-mobility group box-1 (HMGB1), as a highly conserved ubiquitous DNA-binding protein, has been widely studied in various diseases, including inflammation and tumor; however, fewer studies were focused on the mechanisms controlling HMGB1 release compared with the function of HMGB1. Previous studies have proven that ANG II can act as a pro-inflammatory cytokine, both of HMGB1 and ANG II were significantly upregulated in autoimmune diseases; however, the exact role of ANG II in regulating HMGB1 release have not been shown. The present study was to define the effects of ANG II on macrophages and the possible mechanisms in controlling HMGB1 release. Our results showed that ANG II can induce M1 macrophage polarization through upregulated the expression of HMGB1 and caused acetylation of HMGB1 and release via its dissociation from SIRT1, which in a positive feedback upregulates ANG II. Subsequently, HMGB1 inhibitors can reduce the ANG II-elicited polarize of macrophage. Meanwhile, we show that JAK/STAT pathways play an essential role in ANG II-induced HMGB1 nuclear translocation, JAK/STAT specific inhibitors can inhibit ANG II-induced HMGB1 expression. Taken together, our results provide a novel evidence that HMGB1 play a critical role in ANG II mediated macrophage polarization, and we suggest that ANG II mediated HMGB1 release via dissociation from SIRT1, induce hyperacetylation of HMGB1, thus for subsequent release, suggesting that the angiotensin II receptor antagonist is a potential drug target for inhibiting HMGB1 release in inflammation diseases.

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“…Sodium butyrate is a well-known short fatty acid derivative and exhibits good anti-inflammatory property through inhibiting HMGB1 expression. It has been proven that sodium butyrate showed protective effect in myocardial ischemia/reperfusion, severe sepsis and ALI by inhibiting HMGB1 ( 21 , 22 , 40 , 41 ). Sodium butyrate can also improve the performance of diabetic complications ( 42 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

Sodium Butyrate Ameliorates Streptozotocin-Induced Type 1 Diabetes in Mice by Inhibiting the HMGB1 Expression

et al. 2018

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Type 1 diabetes (T1D) is an autoimmune disease characterized by the immune cell-mediated progressive destruction of pancreatic β-cells. High-mobility group box 1 protein (HMGB1) has been recognized as a potential immune mediator to enhance the development of T1D. So we speculated that HMGB1 inhibitors could have anti-diabetic effect. Sodium butyrate is a short fatty acid derivative possessing anti-inflammatory activity by inhibiting HMGB1. In the current study, we evaluated the effects of sodium butyrate in streptozotocin (STZ)-induced T1D mice model. Diabetes was induced by multiple low-dose injections of STZ (40 mg/kg/day for 5 consecutive days), and then sodium butyrate (500 mg/kg/day) was administered by intraperitoneal injection for 7 consecutive days after STZ treatment. Blood glucose, incidence of diabetes, body weight, pancreatic histopathology, the amounts of CD4+T cell subsets, IL-1β level in serum and pancreatic expressions levels of HMGB1, and NF-κB p65 protein were analyzed. The results showed that sodium butyrate treatment decreased blood glucose and serum IL-1β, improved the islet morphology and decreased inflammatory cell infiltration, restored the unbalanced Th1/Th2 ratio, and down-regulated Th17 to normal level. In addition, sodium butyrate treatment can inhibit the pancreatic HMGB1 and NF-κB p65 protein expression. Therefore, we proposed that sodium butyrate should ameliorate STZ-induced T1D by down-regulating NF-κB mediated inflammatory signal pathway through inhibiting HMGB1.

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Sodium butyrate alleviates LPS-induced acute lung injury in mice via inhibiting HMGB1 release

Cited by 51 publications

References 25 publications

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

Angiotensin II enhances the acetylation and release of HMGB1 in RAW264.7 macrophage

Sodium Butyrate Ameliorates Streptozotocin-Induced Type 1 Diabetes in Mice by Inhibiting the HMGB1 Expression

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