Sodium butyrate treatment and fecal microbiota transplantation provide relief from ulcerative colitis-induced prostate enlargement

Abstract

The ability to regulate the gut environment has resulted in remarkable great breakthroughs in the treatment of several diseases. Several studies have found that the regulation of the gut environment might provide relief from the symptoms of benign prostatic hyperplasia. However, the correlation between the gut microenvironment and the colon and prostate glands is still unknown. We found that ulcerative colitis (UC) induced an increase in prostate volumes that could be reversed by sodium butyrate (NaB) and fecal microbiota transplantation (FMT). The mechanism by which UC induced changes in the prostate gland was examined via RNA-Seq. The results show that the expression level of GPER was significantly lower in the prostate gland of UC mices than in normal mices. The expression of GPER could be increased via treatment with NaB or FMT. We found that prostate tissues exhibited higher butryic acid levels after they were treated with NaB or FMT. In experiments conducted in vitro, NaB or the fecal filtrate (FF) from healthy mice up-regulated of the expression of GPER, inhibited cell growth, and induced apoptosis in BPH-1 cells. These changes could be alleviated by treatment with the G15 or in GPER-silenced cells.

Association of ulcerative colitis and acute gastroenteritis with prostate specific antigen: results from National Health and Nutrition Examination Survey from (2009 to 2010) and Mendelian randomization analyses

“…Not only Pca and prostate inflammation but also prostate enlargement contribute to elevated PSA. The previous study that we conducted revealed that UC induced prostate enlargement ( 38 ).…”

Butyrate Prevents the Pathogenic Anemia‐Inflammation Circuit by Facilitating Macrophage Iron Export

“…Second, although both butyrate and entinostat can act as HDACi, they have distinct chemical properties and metabolic activities. Fortunately, as an endogenous and safe metabolite, butyrate supplementation can be achieved by several means, such as sodium butyrate capsules, butyrate enemas, fecal microbiota transplantation (FMT), or the administration of butyrate‐producing probiotics, [ 5 , 23 ] permitting the convenient clinical application.…”

Prostate and gut: Any relationship? A narrative review on the available evidence and putative mechanisms

“…For instance, an increase in prostate volume in patients with ulcerative colitis (UC) was reversed by sodium butyrate and FMT. 77…”

“…More evidence in the support of the regulatory effect of GM on the prostate growth is provided by invasive studies where GM metabolites are regarded as potential therapeutics. For instance, an increase in prostate volume in patients with ulcerative colitis (UC) was reversed by sodium butyrate and FMT 77 …”