Sodium cromoglycate 2 per cent solution in perennial rhinitis: a clinical and histological study

Brain, D. J.; Singh, Kiranjit; Trotter, CL; Viner, Anna

doi:10.1017/s0022215100079664

Cited by 11 publications

(3 citation statements)

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“…However, in another study (Brain et al, 1974) some patients' nasal biopsies showed a similar histological picture to the late skin reactions with perivascular infiltration of chronic inflanimatory cells, and it is likely that these changes will result in some thickening of the submucosa again contributing to nasal obstruction. However, in another study (Brain et al, 1974) some patients' nasal biopsies showed a similar histological picture to the late skin reactions with perivascular infiltration of chronic inflanimatory cells, and it is likely that these changes will result in some thickening of the submucosa again contributing to nasal obstruction.…”

Section: Symptomatologymentioning

confidence: 90%

“…Taylor also found that a proportion of subjects (21%) had both an immediate and late skin reaction and biopsy of the late skin reaction showed perivascular infiltration with mononuclear cells and polymorphonuclear leucocytes, unfortunately biopsies of the late nasal reactions were not performed. However, in another study (Brain et al, 1974) some patients' nasal biopsies showed a similar histological picture to the late skin reactions with perivascular infiltration of chronic inflanimatory cells, and it is likely that these changes will result in some thickening of the submucosa again contributing to nasal obstruction.…”

Section: Symptomatologymentioning

confidence: 90%

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Retrospective survey of 1271 patients diagnosed as perennial rhinitis

Viner¹,

Jackman²

1976

Clin Experimental Allergy

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Data from 1271 patients with perennial rhinitis has been assessed. This condition predominantly affects children and young adults; 31-5% stated that symptoms first appeared before the age of 10 years, less than 10% were aged 50 years or more suggesting that the disease process may well disappear in later life.The total sample size was equally divided between the sexes and the mean age for the sexes was similar. In terms of age distribution a sex difference was found in that the peak incidence for males occurred in the age group 10-19 years whereas for females it was in the third decade (P<0 001).The duration of the disease was, in most cases, between 2 and 9 years but it can extend to over 15 years and thus become subacute or chronic. The major symptom is blocking which could be due to either bistological changes in the mucosa or immunological reactions.Skin tests showed that 64% had a positive reaction to common allergens; however, nasal challenge tests were of little value in determining whether a patient could be classified as allergic. Eosinophils were noted in 66%. The value of skin tests and nasal smears is discussed.

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Section: Symptomatologymentioning

confidence: 90%

Section: Symptomatologymentioning

confidence: 90%

Retrospective survey of 1271 patients diagnosed as perennial rhinitis

Viner¹,

Jackman²

1976

Clin Experimental Allergy

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“…The symptoms of sneezing and running, which are associated with an immediate Type I reaction (Taylor and Shivalkar, 1971) responded clinically quicker than blocking; this may be because blocking is associated with a ‘late’ reaction which in time produces histological changes in the nasal mucosa such as proliferation of goblet cells (Mygind, 1975) and chronic inflammation with cellular infiltration in the submucosa (Brain et al 1974). In those patients whose symptoms are predominantly sneezing and running a clinical response was seen within two weeks, however it would seem advisable to treat patients with nasal obstruction for at least four weeks or perhaps longer to obtain the maximum therapeutic benefit.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Sodium Cromoglycate Nasal Solution and Powder in the Treatment of Allergic Rhinitis

Resta

Carniméo

1982

Int J Clinical Practice

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The efficacy of sodium cromoglycate powder and solution have been compared with placebo in a group comparative trial involving 39 patients with allergic rhinitis over a period of four weeks. A further crossover trial in 20 patients was carried out to compare the efficacy of powder and solution in those whose main symptoms were nasal obstruction. The data show that both sodium cromoglycate powder and solution are effective treatments and suggest that the powder formulation is somewhat better than solution in those patients with rhinorrhoea possibly because the powder is not rapidly washed out with the nasal secretions. In those patients in whom blocking is the predominant symptom the solution appears to offer advantages due to an effective nasal distribution from the device and possibly the effect of a preservative. The incidence of side effects was of a low order.

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Pharmacologic treatment of rhinitis

Simons

1984

Clin Rev Allergy

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Sodium cromoglycate 2 per cent solution in perennial rhinitis: a clinical and histological study

Cited by 11 publications

References 11 publications

Retrospective survey of 1271 patients diagnosed as perennial rhinitis

Retrospective survey of 1271 patients diagnosed as perennial rhinitis

A Comparison of Sodium Cromoglycate Nasal Solution and Powder in the Treatment of Allergic Rhinitis

Pharmacologic treatment of rhinitis

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