Sodium cromoglycate attenuates pulmonary inflammation without influencing bronchial responsiveness in healthy subjects exposed to organic dust

Larsson, Kjell; Larsson, Britt‐Marie; Sandström, Thomas; Sundblad, Britt‐Marie; Palmberg, Lena

doi:10.1046/j.1365-2222.2001.01193.x

Cited by 25 publications

(16 citation statements)

References 41 publications

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“…Moreover, separate and preliminary assessments of the myeloperoxidase (MPO) concentration in BAL fluid displayed a weak increase not corresponding to the increase in neutrophil number (data not shown). Similar findings on MPO and neutrophils have previously been published [31]. Taken together, all these findings imply that, in terms of MPO and HNL, there is actually no true increase in the average activity of each accumulated neutrophil in the human bronchoalveolar space after exposure to organic dust.…”

Section: Discussionsupporting

confidence: 88%

Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust

et al. 2005

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Background: In mice, the cytokine interleukin (IL)-17A causes a local accumulation of neutrophils within the bronchoalveolar space. IL-17A may thereby also contribute to an increased local proteolytic burden. In the current study, we determined whether mRNA for IL-17A is elevated and protein expression of IL-17A occurs locally in inflammatory cells within the human bronchoalveolar space during severe inflammation caused by organic dust. We also assessed the expression of the elastinolytic protease MMP-9 in this airway compartment.

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Section: Discussionsupporting

confidence: 88%

Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust

et al. 2005

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“…This may be a novel future direction because pharmacologic interventions that include inhaled sodium cromoglycate, corticosteroids, and long-acting beta agonists have shown modest and sometimes conflicting effects in the prevention and/or treatment of exposed agriculture workers. 30–32 …”

Section: Discussionmentioning

confidence: 99%

αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease

Poole

Gleason

Bauer

et al. 2012

Annals of Allergy, Asthma & Immunology

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“…Mast cells seem to play a role in the organic-dust-mediated airway inflammatory response since urinary excretion of 9a,11b-prostaglandin F 2 , a prostaglandin D 2 metabolite that is almost exclusively produced by mast cells, increases after exposure [25]. In addition, inhalation of sodium cromoglycate alters the inflammatory reaction to swine dust exposure, probably by interacting with mast cells [26]. It was recently shown that dexamethasone potently inhibits TNF-a production by activated mast cells in vitro [27].…”

Section: Discussionmentioning

confidence: 99%

The effect of fluticasone on the airway inflammatory response to organic dust

Palmberg²

2004

Eur Respir J

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The effect of fluticasone on the airway inflammatory response to organic dust. A. Ek, L. Palmberg, K. Larsson. #ERS Journals Ltd 2004. ABSTRACT: Exposure to organic dust in a swine house causes acute airway inflammation and increased bronchial responsiveness to methacholine in healthy subjects. The aim of this study was to investigate whether an inhaled glucocorticoid, fluticasone propionate, alters the acute airway responses induced by exposure in a swine barn.In 15 healthy subjects, analysis of nasal lavage fluids, serum samples and bronchial methacholine responsiveness were performed before and after exposure to organic dust in a swine house for 3 h. Seven subjects received fluticasone propionate (500 mg b.i.d. by inhalation and 100 mg intranasally once daily) and eight subjects received placebo during the 2 weeks prior to exposure.Post-exposure plasma interleukin (IL)-6 levels and body temperature were significantly lower in the fluticasone group than in the placebo group. Intranasally administered fluticasone propionate significantly attenuated the plasma protein (assessed as albumin concentrations) leakage and IL-8 and tumour necrosis factor-a response induced by exposure. Fluticasone propionate inhalation exerted no influence on the increased bronchial responsiveness to methacholine induced by exposure.In conclusion, glucocorticoid treatment attenuated the inflammatory response to inhaled organic dust without influencing the increased bronchial responsiveness to methacholine.

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Sodium cromoglycate attenuates pulmonary inflammation without influencing bronchial responsiveness in healthy subjects exposed to organic dust

Abstract: Sodium cromoglycate alters the airway inflammatory response to inhaled organic dust without influencing the dust-induced increase in bronchial responsiveness to methacholine.

Cited by 25 publications

References 41 publications

Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust

Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust

αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease

The effect of fluticasone on the airway inflammatory response to organic dust

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