Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron

Sharma, Gaurav; Naushad, Mu.; Thakur, Bharti; Kumar, Amit; Negi, Poonam; Saini, Reena V.; Chahal, Anterpreet; Kumar, Ashok; Stadler, Florian J.; Aqil, U.M.H.

doi:10.3390/ijerph15030414

Cited by 18 publications

(17 citation statements)

References 44 publications

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“…T80 has been assessed to be non-cytotoxic and has potential as a simple, rapid and non-toxic method for delivering drugs to cells in culture [ 47 ]. The nano-drug delivery systems containing SLS revealed no toxicity to human cells on MTT assay method of cytotoxicity studies [ 22 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Anti-Cancer Activity of Nanostructured Lipid Carriers Containing Imatinib

et al. 2021

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Breast cancer is the most widespread malignancy in women worldwide. Nanostructured lipid carriers (NLCs) have proven effective in the treatment of cancer. NLCs loaded with imatinib (IMA) (NANIMA) were prepared and evaluated for their in vitro efficacy in MCF-7 breast cancer cells. The hot homogenization method was used for the preparation of NANIMAs. An aqueous solution of surfactants (hot) was mixed with a molten mixture of stearic acid and sesame oil (hot) under homogenization. The prepared NANIMAs were characterized and evaluated for size, polydispersity index, zeta potential, encapsulation efficiency, release studies, stability studies, and MTT assay (cytotoxicity studies). The optimized NANIMAs revealed a particle size of 104.63 ± 9.55 d.nm, PdI of 0.227 ± 0.06, and EE of 99.79 ± 0.03. All of the NANIMAs revealed slow and sustained release behavior. The surfactants used in the preparation of the NANIMAs exhibited their effects on particle size, zeta potential, encapsulation efficiency, stability studies, and release studies. The cytotoxicity studies unveiled an 8.75 times increase in cytotoxicity for the optimized NANIMAs (IC50 = 6 µM) when compared to IMA alone (IC50 = 52.5 µM) on MCF-7 breast cancer cells. In the future, NLCs containing IMA will possibly be employed to cure breast cancer. A small amount of IMA loaded into the NLCs will be better than IMA alone for the treatment of breast cancer. Moreover, patients will likely exhibit less adverse effects than in the case of IMA alone. Consequently, NANIMAs could prove to be useful for effective breast cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Anti-Cancer Activity of Nanostructured Lipid Carriers Containing Imatinib

et al. 2021

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“…Increased drug entrapment efficiency indicates the capability of nonionic surfactants for (Bini et al, 2012;Karim et al, 2010). The percent drug entrapment efficiency (%EE) of our systems (Table 1) is found to be substantially relative to the reported systems, such as Wang et al have reported 56.5% (Wang et al, 2019), and Sharma et al have reported 45.38% (Sharma et al, 2018). The increased drug entrapment can be attributed to many factors of the niosomal vesicles.…”

Section: Drug Entrapment Efficiencymentioning

confidence: 41%

Synthesis and Characterization of Sulfanilamide‐Based Nonionic Surfactants and Evaluation of Their Nano‐Vesicular Drug Loading Application

Ali

Saifullah

El‐Haj³

et al. 2020

J Surfact & Detergents

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Nonionic surfactants are highly stable and cost‐effective and receiving acceptance for applications in many diverse fields including drug delivery, due to their distinctive properties. Here, we report on the synthesis and characterization of sulfanilamide‐based nonionic surfactants for nanoscale vesicular drug loading applications. Nonionic surfactants were synthesized through alkylation of sulfanilamide with alkyl halides that possessed diverse degrees of lipophilicity. They were explored for their nanovesicular drug loading with Cefixime as a hydrophobic model drug. Drug‐loaded nanovesicles were characterized for surface morphologies, size, size distribution, surface charge, and drug loading efficiency using atomic force microscopy (AFM), dynamic light scattering (DLS), and UV–visible spectrophotometry. All of the synthesized nonionic surfactants revealed their CMC values in 0.055–0.035 mM range depending upon the lipophilic chain length of surfactants. They caused a decreased hemoglobin release and low toxicity against cell culture. They self‐assembled and loaded an increased amount of drug in the form of nanorange spherical shape niosomal vesicles. Results of the current study verify these synthesized nonionic surfactants are hemocompatible, nontoxic, and capable of self‐assembling into nanorange niosomal vesicles. These niosomal vesicles can be suggested as safe and highly efficient nanocarriers for hydrophobic drug loading and delivery.

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“…Among natural polymers, gelatin due to unique and favorable properties such as enzymatically degradable and water solubility, as well as its low cost of producing, can be used as biomedical hydrogel [32]. As previously mentioned, gelatin due to its abundance of inherent amine, hydroxyl, and carboxyl functional group can easily modify with different groups such as methacrylol and thiol groups (Figure 3) [32][33][34]. One of the ways for crosslinking of gelatin is modifying by grafting of methacrylol (methacrylamides) to create the photo-crosslinkable hydrogels [32,33].…”

Section: Photo-crosslinkingmentioning

confidence: 99%

“…Indeed, hydrogels consist mostly of water (70-99%); therefore, they shows the physical and structural similarity with body tissues. Moreover, this similarity of hydrogels offers excellent biocompatibility and great potential for encapsulating cells and hydrophilic drugs [34,53,55]. In addition to, risk of drug denaturation and aggregation is low as hydrogels forms in aqueous solution.…”

Section: Gelatin-based Hydrogel For Drug Releasementioning

confidence: 99%

Gelatin Based Hydrogels for Tissue Engineering and Drug Delivery Applications

Amirian¹

2021

Materials Research Foundations

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Gelatin is one of the most popular natural polymers which is widely used in food, pharmaceutical, biomedical and cosmetic industries. The gelatin has been prepared from different sources such as porcine skin, cattle bone, and fish, etc. Depending on the type of acidic and alkali extraction processes the type of gelatin A and B were obtained. This chapter provides a comprehensive overview of preparation of gelatin base hydrogel. Furthermore, we evaluate their method of crosslinking through Schift-base, Mischeal-addition-based, light, UV, chemical, and physical crosslinking. Moreover, due to the unique properties of gelatin they have the ability to immobilize cells and can be applied for stem cell and drug delivery in biomedical applications.

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Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron

Cited by 18 publications

References 44 publications

Preparation, Characterization, and Anti-Cancer Activity of Nanostructured Lipid Carriers Containing Imatinib

Preparation, Characterization, and Anti-Cancer Activity of Nanostructured Lipid Carriers Containing Imatinib

Synthesis and Characterization of Sulfanilamide‐Based Nonionic Surfactants and Evaluation of Their Nano‐Vesicular Drug Loading Application

Gelatin Based Hydrogels for Tissue Engineering and Drug Delivery Applications

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