Sodium excretion and intrarenal hemodynamics in thoracic inferior vena cava constriction

Crumb, C. K.; Minuth, Andre N.; Flasterstein, A; Hebert, CS; Eknoyan, Garabed; Martinez-Maldonado, M.; Suki, Wadi N.

doi:10.1152/ajprenal.1977.232.6.f507

Cited by 4 publications

(6 citation statements)

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“…In this way, the CVP increases above the upper limit of normal (> 8 mmHg), thereby inducing venous congestion in a similar way as seen in patients [2]. Tying a surgical wire [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]; inserting a metal clamp [59,60], adjustable band [61][62][63][64], or constrictor cuff around the IVC [65,66]; or placing an inflatable balloon via the femoral vein [49,53,[67][68][69] are frequently used techniques to constrict the IVC. As a result, CVP varied between 11 to 15 mmHg below the constriction while the CVP above the constriction remained unchanged [44,65].…”

Section: Inferior Vena Cava Constriction: Subdiaphragmatic Venous Conmentioning

confidence: 99%

“…Most of the existing animal models of subdiaphragmatic congestion do not meet the criteria to be a clinically relevant animal model of isolated congestion (Table 2). First, the exact technique to induce congestion [44,45,47,48,55,56], the anatomical location of where the constriction is applied [44,46,49,52,53,[59][60][61][62][63][64][65][66][67][68], and the degree of constriction were not always properly described [46,47,50,52,54,56,65,66,68,69]. Second, it was not always clear whether venous congestion was actually induced, since hemodynamic or echocardiographic measurements were not performed in these studies [46-52, 54-56, 58, 59, 69].…”

Section: Inferior Vena Cava Constriction: Subdiaphragmatic Venous Conmentioning

confidence: 99%

“…Third, often a local and no systemic congestion was induced, when the abdominal IVC was constricted at the level of the renal or hepatic veins [43,47,48,50,51,[54][55][56][57][58]68], in contrast to patients in which the abdomen's entire venous system is congested, potentially explaining contradicting results in animal models versus clinical trials. Fourth, the chronic phase of congestion-weeks to months-was not investigated as the constriction was only maintained for hours to days, or the animals were only often studied for a few days [44][45][46][47][48][49][50][51][52][53][54][55][56][58][59][60][61][62][63][64][65][66][67][68][69]. Finally, the effect of constriction on abdominal organ function, besides the kidneys, was not investigated [47,51,54,58,[61][62][63][64][67]…”

Section: Inferior Vena Cava Constriction: Subdiaphragmatic Venous Conmentioning

confidence: 99%

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Current animal models for the study of congestion in heart failure: an overview

et al. 2019

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Congestion (i.e., backward failure) is an important culprit mechanism driving disease progression in heart failure. Nevertheless, congestion remains often underappreciated and clinicians underestimate the importance of congestion on the pathophysiology of decompensation in heart failure. In patients, it is however difficult to study how isolated congestion contributes to organ dysfunction, since heart failure and chronic kidney disease very often coexist in the so-called cardiorenal syndrome. Here, we review the existing relevant and suitable backward heart failure animal models to induce congestion, induced in the left-(i.e., myocardial infarction, rapid ventricular pacing) or right-sided heart (i.e., aorta-caval shunt, mitral valve regurgitation, and monocrotaline), and more specific animal models of congestion, induced by saline infusion or inferior vena cava constriction. Next, we examine critically how representative they are for the clinical situation. After all, a relevant animal model of isolated congestion offers the unique possibility of studying the effects of congestion in heart failure and the cardiorenal syndrome, separately from forward failure (i.e., impaired cardiac output). In this respect, new treatment options can be discovered.

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Section: Inferior Vena Cava Constriction: Subdiaphragmatic Venous Conmentioning

confidence: 99%

Section: Inferior Vena Cava Constriction: Subdiaphragmatic Venous Conmentioning

confidence: 99%

Section: Inferior Vena Cava Constriction: Subdiaphragmatic Venous Conmentioning

confidence: 99%

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Current animal models for the study of congestion in heart failure: an overview

et al. 2019

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“…Subhepatic occlusion of the AIVC did not depress cortical blood flow or depressed it only moderately. However, several other investigators found that changes in intrarenal blood flow distribution are not necessary for the development of salt retention during acute caval constriction when the microsphere technique was used for measuring intrarenal blood flow distribution (Slick et al, 1974;Crumb et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

Effects of renal and hepatic venous congestion on renal function in the presence of low and normal cardiac output in dogs.

Priebe¹,

Heimann²,

Hedley-Whyte³

1980

Circulation Research

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We investigated the effect of acute renal vein and hepatic vein hypertension induced by partial balloon-occlusion of the abdominal inferior vena cava (AIVC-O) and the thoracic inferior vena cava (TIVC-O) on systemic and renal hemodynamics and renal function in 13 dogs anesthetized with pentobarbital. When a renal vein pressure of 13 cm H2O was induced by AIVC-O, cardiac output, stroke volume, central venous pressure, renal blood flow, and renal function (GFR, free water clearance, osmolar clearance, urine output, urinary sodium excretion, fractional sodium excretion) decreased significantly. When systemic hemodynamics were restored to control values by transfusion of autologous blood (mean of 9 ml/kg body weight) while renal vein pressure was kept elevated, renal function also was restored. A hepatic venous pressure of 13 cm H2O then was induced by TIVC-O. The effects on systemic hemodynamics and renal function were very similar to those observed during AIVC-O. When systemic hemodynamics were restored to control values by transfusion (mean of 9 ml/kg), while hepatic venous hypertension was maintained by TIVC-O, renal function also was restored. Despite significant changes in natriuresis and diuresis, intrarenal blood flow distribution, as determined by the radioactive microsphere technique, remained essentially unchanged throughout. We conclude that renal and hepatic congestion induced by partial AIVC-O and TIVC-O do not, per se, alter renal function significantly.

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“…Studies using ra dioactive microspheres have likewise demon strated an association between some antinatriuretic conditions and redistribution of RBF to deeper cortex [4,20], However, the same pattern of redistribution can be asso ciated with natriuresis under other circum stances [21][22][23]. Furthermore, Crumb et al [6] have recently shown that changes in intracortical flow distribution are not crit ical in determining the renal handling of so dium in the model of thoracic inferior vena cava constriction. With acute urinary tract obstruction, we found no significant differ ence in the changes in the ratios of frac tional excretion of sodium between nonpretreated animals and indomethacin-pretreated animals, despite the fact that the redistribu tion of flow to deeper cortex seen in the nonpretreated animals was abolished in the animals who received indomethacin.…”

Section: Discussionmentioning

confidence: 99%

Effect of Indomethacin on Changes of Acute Ureteral Pressure Elevation in the Dog

Edwards

Suki

1978

Kidney Blood Press Res

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The effects of indomethacin on hemodynamic and excretory alterations produced by acute ureteral obstruction were investigated in anesthetized dogs by means of radiolabeled microspheres and clearance techniques. Renal blood flow in untreated animals increased by 40 ± 12% with acute ureteral pressure elevation in comparison to the contralateral unobstructed kidney. This increase was only 7 ± 3% (p < 0.01) in indomethacin-treated animals. Likewise untreated animals exhibited a redistribution of blood flow from superficial to deeper cortex while indomethacin-treated animals showed no redistribution (p < 0.025). However, indomethacin treatment did not alter changes in glomrular filtration rate or electrolyte excretion of acute obstruction. These results suggest that prostaglandins or closely related compounds are involved in the hemodynamic changes of acute obstruction, but that they do not play an important role in the determination of glomerular filtration rate or electrolyte excretion.

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Sodium excretion and intrarenal hemodynamics in thoracic inferior vena cava constriction

Cited by 4 publications

References 0 publications

Current animal models for the study of congestion in heart failure: an overview

Current animal models for the study of congestion in heart failure: an overview

Effects of renal and hepatic venous congestion on renal function in the presence of low and normal cardiac output in dogs.

Effect of Indomethacin on Changes of Acute Ureteral Pressure Elevation in the Dog

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