Sodium excretion patterns during and following intravenous sodium chloride loads in normal and hypertensive pregnancies

Sarles, H; Hill, Sandra S.; Leblanc, Alvin L.; Smith, Garland H.; Canales, Carlos O.; Remmers, August R.

doi:10.1016/0002-9378(68)90424-9

Cited by 41 publications

(2 citation statements)

References 10 publications

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“…These experiments extend observations concerning the natriuretic response to volume expansion of pregnant women (20)(21)(22)(23), as the changes in V%, CH20%, and Curea/Cinulin suggest that during hypotonic saline loading of lateral recumbent subjects, fractional sodium reabsorption decreased in the proximal nephron. This study also underscores the importance of posture as a determinant of sodium excretion in late pregnancy, for supine recumbency was antinatriuretic despite considerable volume loading.…”

Section: Discussionsupporting

confidence: 85%

Effect of hypotonic expansion on sodium, water, and urea excretion in late pregnancy: the influence of posture on these results

Lindheimer¹,

Weston²

1969

J. Clin. Invest.

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A B S T R A C T Mineralocorticoid-treated, normotensive third trimester subjects positioned in lateral recumbency were studied before and during the infusion of 300 mEq of hypotonic saline. Urinary sodium excretion increased in all subjects from a mean value of 199 to 416 IAEq/min.In 12 maximally hydrated subjects free water clearance (CH2o) and urine flow (V) increased from means of 7.54 and 9.50 to 11.6 and 14.5 ml/100 ml of glomerular filtrate (GFR) Also the ratio of urea to inulin clearance (Curen/Cinuiln) increased from 0.59 to 0.64. The changes in the renal handling of water and urea suggest that fractional sodium reabsorption decreased at proximal nephron sites.The subjects then assumed a supine position, and the results were compared to those obtained during the lateral recumbent control periods. Filtered sodium decreased in 11 experiments, but in five studies it remained up to 2.6 mEq/min above control values. There was only one instance in which a significant increase in sodium excretion occurred. It was concluded that supine recumbency blunts natriuresis despite volume expansion or an increase in the filtered load of sodium.Finally, in the 12 hydrated subjects supine recumbency reduced CH2o and V from a mean of 11.6 and 14.5 to 6.2 and 8.2 ml/100 ml of GFR. In eight of these experiPreliminary reports of this work have been published in abstract form:

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Section: Discussionsupporting

confidence: 85%

Effect of hypotonic expansion on sodium, water, and urea excretion in late pregnancy: the influence of posture on these results

Lindheimer¹,

Weston²

1969

J. Clin. Invest.

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show abstract

“…Experimental evidence in humans shows that salt loading normal gravidas results in excretion of excessive sodium, allowing the gravida to remain in balance [3]. During salt restriction, much sodium is lost before adjustment in sodium intake and output can be made and balance is regained [9]. Similar observations were made in this study using an animal model.…”

Section: Discussionsupporting

confidence: 85%