Sodium fluorescein in pediatric neurosurgery: a systematic review with technical considerations and future perspectives

Laurentis, Camilla de; Bteich, Fred; Beuriat, P.A.; Mottolèse, C.; Giussani, Carlo; Szathmari, A.; Vinchon, Matthieu; Rocco, F. Di

doi:10.1007/s00381-022-05772-5

Cited by 10 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… − This molecule has an excitation wavelength of 494 nm and an emission wavelength of 512 nm, in the visible range. The safety of this fluorophore is well-established, with more than 40 years of experience in the clinical settings. , Due to its bright visible-range fluorescence, fluorescein sodium has been used as a contrast dye for the identification of some tumors, such as central nerve system tumors. − The mechanism of visualization remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Activity-Based Fluorescence Diagnostics for Cancer

Fujita,

Urano

2024

Chem. Rev.

View full text Add to dashboard Cite

Fluorescence imaging is one of the most promising approaches to achieve intraoperative assessment of the tumor/normal tissue margins during cancer surgery. This is critical to improve the patients' prognosis, and therefore various molecular fluorescence imaging probes have been developed for the identification of cancer lesions during surgery. Among them, "activatable" fluorescence probes that react with cancer-specific biomarker enzymes to generate fluorescence signals have great potential for high-contrast cancer imaging due to their low background fluorescence and high signal amplification by enzymatic turnover. Over the past two decades, activatable fluorescence probes employing various fluorescence control mechanisms have been developed worldwide for this purpose. Furthermore, new biomarker enzymatic activities for specific types of cancers have been identified, enabling visualization of various types of cancers with high sensitivity and specificity. This Review focuses on recent advances in the design, function and characteristics of activatable fluorescence probes that target cancer-specific enzymatic activities for cancer imaging and also discusses future prospects in the field of activity-based diagnostics for cancer. CONTENTS

show abstract