“…In addition, NaF reportedly alters several cellular functions, e.g., carbohydrate metabolism in rat hepatocytes (Shahed et al, 1979a), histamine release from mast cells (Patkar et al, 1977;Alm, 1983), serotonin and nucleotide release from human blood platelets (Mirer and Daniel, 1983), granulocyte function (Elferink et al, 1982), and superoxide formation in polymorphonuclear leukocytes (Elferink, 1981;Sbarra and Karnovsky, 1959;Gabler et al, 1986), and increases gastric H+ secretion (Assem and Wan, 1982;Shayiq et al, 1984). We have previously reported that a single acute dose of NaF increased cAMP concentration and decreased amylase content in rat parotid glands (Shahed et al, 1985).…”