1983
DOI: 10.1007/bf01967316
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Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines

Abstract: Calcium triggers the secretion of histamine from mast cells after previous exposure to sodium fluoride. The secretory process can be divided into a fluoride-activation step and a calcium-induced secretory step. It was observed that the fluoride-activation step is accompanied by an elevation of cAMP levels within the cells. The attained high levels of cAMP persist during histamine release. It was further found that catecholamines do not markedly alter the fluoride-induced histamine release. It was also confirme… Show more

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Cited by 14 publications
(4 citation statements)
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“…Mast cells were purified to greater than 95% homogeneity by density gradient centrifugation over Percoll [8]. Levels of cAMP were determined essentially as previously described [91.…”
Section: Determination Of Cyclic 3' 5'-adenosine Monophosphate (Camp)mentioning
confidence: 99%
“…Mast cells were purified to greater than 95% homogeneity by density gradient centrifugation over Percoll [8]. Levels of cAMP were determined essentially as previously described [91.…”
Section: Determination Of Cyclic 3' 5'-adenosine Monophosphate (Camp)mentioning
confidence: 99%
“…The pH of the solution was adjusted to 7-4 before use. Where indicated, mast cells were purified to greater than 95 % homogeneity by density gradient centrifugation over Percoll as previously reported (Alm, 1983). In simple release experiments, cells were washed and suspended in Tyrode buffer.…”
Section: Sprague-dawley Ratsmentioning
confidence: 99%
“…In addition, NaF reportedly alters several cellular functions, e.g., carbohydrate metabolism in rat hepatocytes (Shahed et al, 1979a), histamine release from mast cells (Patkar et al, 1977;Alm, 1983), serotonin and nucleotide release from human blood platelets (Mirer and Daniel, 1983), granulocyte function (Elferink et al, 1982), and superoxide formation in polymorphonuclear leukocytes (Elferink, 1981;Sbarra and Karnovsky, 1959;Gabler et al, 1986), and increases gastric H+ secretion (Assem and Wan, 1982;Shayiq et al, 1984). We have previously reported that a single acute dose of NaF increased cAMP concentration and decreased amylase content in rat parotid glands (Shahed et al, 1985).…”
Section: )mentioning
confidence: 95%