Sodium glucose co-transporter 2 inhibitors successfully attenuated seasonal change of glycated haemoglobin A1c

Yamada, Eijiro; Saito, Tsugumichi; Niijima, Yawara; Okada, Shuichi; Yamada, Masanobu

doi:10.7861/clinmedicine.17-4-377

Cited by 2 publications

(1 citation statement)

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“…In our study, we observed a similar influence of seasonal changes on the variation of HbA1c: the peak and trough HbA1c values appeared in March and August, respectively (Supplementary Figure 7 ). Yamada et al reported that add-use of SGLT2 inhibitors attenuated the tendency for HbA1c to worsen towards the winter season [ 36 ], suggesting that a moderate adjustment in antiglycemic medication is a valuable strategy for treating seasonal variation in HbA1c.…”

Section: Discussionmentioning

confidence: 99%

Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study

Yao

Kondo

Oniki

et al. 2022

Journal of Diabetes Research

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Aims. This study is aimed at clarifying the relationship between visit-to-visit variability of glycated hemoglobin (HbA1c) and the risk of diabetic kidney disease (DKD) and to identifying the most useful index of visit-to-visit variability of HbA1c. Methods. This clinic-based retrospective longitudinal study included 699 Japanese type 2 diabetes mellitus patients. Visit-to-visit variability of HbA1c was calculated as the internal standard deviation of HbA1c (HbA1c-SD), the coefficient of variation of HbA1c (HbA1c-CV), the HbA1c change score (HbA1c-HVS), and the area under the HbA1c curve (HbA1c-AUC) with 3-year serial HbA1c measurement data, and the associations between these indices and the development/progression of DKD were examined. Results. Cox proportional hazards models showed that the HbA1c-SD and HbA1c-AUC were associated with the incidence of microalbuminuria, independently of the HbA1c level. These results were verified and replicated in propensity score (PS) matching and bootstrap analyses. Moreover, the HbA1c-SD and HbA1c-AUC were also associated with oxidized human serum albumin (HSA), an oxidative stress marker. Conclusions. Visit-to-visit variability of HbA1c was an independent risk factor of microalbuminuria in association with oxidative stress among type 2 diabetes mellitus patients. HbA1c-AUC, a novel index of HbA1c variability, may be a potent prognostic indicator in predicting the risk of microalbuminuria.

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Section: Discussionmentioning

confidence: 99%