Sodium Hyaluronate and Platelet-Rich Plasma for Partial-Thickness Rotator Cuff Tears

Abstract

Our study provided evidence of the efficacy of PRP injection in the healing of small to medium PTRCTs. Moreover, the combined injection of SH and PRP yielded a better clinical outcome than SH or PRP alone.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Effectiveness of Platelet-Rich Plasma Injection in Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…We excluded two studies comparing PRP to corticosteroid [21,22]. Five RCTs were included for the qualitative synthesis as well as the final meta-analysis (Table 1) [10][11][12][13][14]. The comparison between the PRP and control group in this study comprised 283 patients [10][11][12][13][14].…”

“…Five RCTs were included for the qualitative synthesis as well as the final meta-analysis (Table 1) [10][11][12][13][14]. The comparison between the PRP and control group in this study comprised 283 patients [10][11][12][13][14]. Two of the included studies compared PRP with physiotherapy [12,13], another two studies compared PRP with saline injection [11,14], and one study investigated the comparison between PRP and dry needling [10].…”

“…included studies compared PRP with physiotherapy [12,13], another two studies compared PRP with saline injection [11,14], and one study investigated the comparison between PRP and dry needling [10]. The mean age of the enrolled patients ranged from 39.9 to 59.7 years in the five included studies.…”

“…The outcomes were extracted at baseline and different follow-up time points for all studies. Among the five studies, four used ultrasound for injection guidance [10,11,13,14]. Regarding the injection site, two RCTs performed subacromial injections [11,14], one with supraspinatus injections [10], one with injured tendon and subacromial injections [13], and one with intra-articular injections [12].…”

“…PRP has been shown to provide beneficial effects on musculoskeletal diseases including chronic joint degeneration and tendinopathy [8,9]. Some new emerging randomized controlled trials (RCTs) regarding PRP injection for rotator cuff tendinopathy have been published recently [10][11][12][13][14]. In addition, positive evidence supporting the efficacy of PRP for treating rotator cuff tendinopathy has been reported in a previous review, but no comparison with conventional therapies such as physiotherapy was made [15].…”