Sodium <i>N</i>-Chlorobenzenesulfonamide as a Selective Oxidant for Hexosamines in Alkaline Medium:  A Kinetic and Mechanistic Study

Rangappa, Kanchugarakoppal S.; Raghavendra, M. P.; Mahadevappa, D. S.; Channegowda, D.

doi:10.1021/jo971398t

Cited by 126 publications

(72 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A vant Hoff's plot was made for the Scheme 1. variation of K 2 with temperature [i.e., log K 2 versus 1/T (r > 0.9985, S 0.036)] and the values of the enthalpy of reaction, DH , entropy of reaction, DS, and free energy of reaction, DG, were calculated as 58.1 ± 2.6 kJ mol À1 , 253 ± 12 J K À1 mol À1 and À19.4 ± 1.0 kJ mol À1 , respectively. A comparison of the latter values with those obtained for the slow step of the reaction shows that these values mainly refer to the rate limiting step, supporting the fact that the reaction before the rate determining step are fairly slow and involves high activation energy [31].…”

Section: Discussionsupporting

confidence: 53%

Kinetic, Mechanistic and Spectral Investigation of Ruthenium(III) Catalysed Oxidation of Atenolol by Alkaline Diperiodatonickelate(IV) (Stopped Flow Technique)

2004

View full text Add to dashboard Cite

The kinetics of ruthenium(III) catalysed oxidation of atenolol by diperiodatonickelate(IV) (DPN) in alkaline medium at a constant ionic strength of 1.0 mol dm À3 has been studied spectrophotometrically using a rapid kinetic accessory. The reaction exhibits 1:1 stoichiometry (DPN:atenolol). The reaction shows first order dependence on [DPN] and [Ruthenium(III)] and apparent less than unit order dependence each in atenolol and alkali concentrations. Addition of periodate has no effect on the rate of reaction. Effect of added products, ionic strength and dielectric constant of the reaction medium have been investigated. The main products were identified by IR, NMR, fluorimetry and mass spectral studies. The results suggest the formation of a complex between the atenolol and ruthenium(III) species which reacts with one mole of diperiodatonickelate(IV) species in a rate determining step, resulting in the formation of a free radical, which in a subsequent fast step yields the products. The reaction constants involved in the mechanism were evaluated. The activation parameters were computed with respect to the slow step of the mechanism and discussed.

show abstract

Section: Discussionsupporting

confidence: 53%

Kinetic, Mechanistic and Spectral Investigation of Ruthenium(III) Catalysed Oxidation of Atenolol by Alkaline Diperiodatonickelate(IV) (Stopped Flow Technique)

2004

View full text Add to dashboard Cite

show abstract

“…A comparison of the later values (from K2) with those obtained for the slow step of the reaction shows that these values mainly refer to the rate-limiting step, supporting the fact that the reaction before rate determining step is fairly fast and involves low activation energy. 27 The negative value of indicate that the complex (C) is more ordered than the reactant. 28 A detailed mechanistic explanation is given in Scheme 2.…”

Section: Discussionmentioning

confidence: 99%

Spectrophotometric Investigation of Oxidation of Cefpodoxime Proxetil by Permanganate in Alkaline Medium: A Kinetic Study

Khan¹,

Mohd²,

Bano³

et al. 2009

Journal of the Korean Chemical Society

View full text Add to dashboard Cite

ABSTRACT.A Kinetics pathway of oxidation of Cefpodoxime Proxetil by permanganate in alkaline medium at a constant ionic strength has been studied spectrophotometrically. The reaction showed first order kinetics in permanganate ion concentration and an order less than unity in cefpodoxime acid and alkali concentrations. Increasing ionic strength of the medium increase the rate. The oxidation reaction proceeds via an alkali-permanganate species which forms a complex with cefpodoxime acid. The latter decomposes slowly, followed by a fast reaction between a free radical of cefpodoxime acid and another molecule of permanganate to give the products. Investigations of the reaction at different temperatures allowed the determination of activation parameters with respect to the slow step of proposed mechanism and fallows first order kinetics. The proposed mechanism and the derived rate laws are consistent with the observed kinetics.

show abstract

“…This leads to the formation of compacted intermediate complex and such activated complex is more ordered than the reactants due to loss of degree of freedom [28]. The experimental values of H ≠ and S ≠ were both favorable for electron-transfer process [29]. Again, the positive values of H ≠ and G ≠ indicate endothermic formation of the intermediate and its non-spontaneity, respectively.…”

Section: Discussionmentioning

confidence: 99%

Base-Catalyzed Oxidation of Aminotriazole Derivative by Permanganate Ion in Aqueous Alkaline Medium: A Kinetic Study

Fawzy¹

2015

IJIRSET

View full text Add to dashboard Cite

Kinetic investigation on the oxidation of one of the aminotriazole derivatives, namely N,N-dimethyl-N'-(4H-1,2,4-triazol-3-yl) formamidine (ATF) by permanganate ion in alkaline medium has been performed at a constant ionic strength of 0.1 mol dm -3 and at 25 o C. The progress of the reaction was followed spectrophotometrically. Both spectroscopic and kinetic evidences reveal formation of a 1:1 intermediate complex between the oxidant and substrate. The influence of pH on the oxidation rate indicated that the reaction is base-catalyzed. The reaction shows first order dependence with respect to , and fractional-first order dependences on both [ATF] and [OH -]. Increasing ionic strength and dielectric constant did not affect the reaction rate. Addition of small amounts of alkali-metal ion catalysts was found to accelerate the oxidation rate and the order of effectiveness of the ions was: Li + > Na + > K + . The final oxidation products of ATF were identified as 3-aminotriazole, dimethyl amine and carbon dioxide. A plausible reaction mechanism consistent with the kinetic observations is proposed, and the reaction constants involved in the different steps of the mechanism have been evaluated. The activation parameters with respect to the slow step of the reaction, along with thermodynamic quantities of the equilibrium constants are calculated and discussed.

show abstract

Sodium N-Chlorobenzenesulfonamide as a Selective Oxidant for Hexosamines in Alkaline Medium: A Kinetic and Mechanistic Study

Cited by 126 publications

References 16 publications

Kinetic, Mechanistic and Spectral Investigation of Ruthenium(III) Catalysed Oxidation of Atenolol by Alkaline Diperiodatonickelate(IV) (Stopped Flow Technique)

Kinetic, Mechanistic and Spectral Investigation of Ruthenium(III) Catalysed Oxidation of Atenolol by Alkaline Diperiodatonickelate(IV) (Stopped Flow Technique)

Spectrophotometric Investigation of Oxidation of Cefpodoxime Proxetil by Permanganate in Alkaline Medium: A Kinetic Study

Base-Catalyzed Oxidation of Aminotriazole Derivative by Permanganate Ion in Aqueous Alkaline Medium: A Kinetic Study

Contact Info

Product

Resources

About