Sodium intake and renal responses to captopril in normal man and in essential hypertension

Hollenberg, Norman K.; Meggs, Leonard G.; Williams, Gordon H.; Katz, Jack L.; Garnic, J D; Harrington, Donald P.

doi:10.1038/ki.1981.126

Cited by 164 publications

(83 citation statements)

References 18 publications

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“…Acute studies with captopril produced either an increase or no change in ERPF and inconstant changes in GFR (Hollenberg et al, 1981;Mimran et al, 1979;Rockel et al, 1980). Minoxidil or carprazidil (methyl-(3,6-dihydro-1(2H)-pyridyl)-2-oxo-2H-1,2,4 oxodiazolo-2,3-a-pyrimidine-7-carbamate, Ro 12-4713, a new vasodilator) do not significantly modify ERPF, GFR or sodium excretion (Gilmore et al, 1970;Grimm et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of combined vasodilation and beta‐adrenoceptor blockade with prizidilol on renal function.

Boehringer¹,

Weidmann²,

Link³

et al. 1983

Brit J Clinical Pharma

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1 The effects of a single oral dose of 600 mg of prizidilol on renal function were studied 5 to 6 h after dosing in six normal subjects and eight patients with essential hypertension. 2 Mean arterial blood pressure was reduced to 92% of the control value in normal subjects and to 75% in hypertensive patients. Heart rate increased slightly. 3 In normal subjects, effective renal plasma flow was increased to 107% of control values while glomerular filtration rate (83%), filtration fraction (79%), sodium (84%) and potassium (50%) clearances were significantly decreased. 4 In hypertensive subjects, effective renal plasma flow was increased to 120% of control values, while glomerular filtration rate (67%), filtration fraction (57%), sodium (27%) and potassium (72%) clearances were significantly decreased. 5 Plasma noradrenaline increased significantly in normal subjects (150%) and in patients (173%).Plasma renin activity, aldosterone and epinephrine levels did not change consistently. 6 The results indicate that the acute effects of prizidilol on blood pressure and renal function are more marked in hypertensive than in normotensive subjects. Prizidilol increases renal plasma flow like hydralazine and depresses glomerular filtration rate and fractional sodium excretion like endralazine. In addition to the fall in arterial pressure, efferent vasodilation and/or a specific effect on the glomerular ultrafiltration coefficient Kf may account for the striking decrease in filtration fraction.

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Section: Discussionmentioning

confidence: 99%

Acute effects of combined vasodilation and beta‐adrenoceptor blockade with prizidilol on renal function.

Boehringer¹,

Weidmann²,

Link³

et al. 1983

Brit J Clinical Pharma

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show abstract

“…The effect on the glomerular filtration rate is variable and depends on the experimental conditions (Mimran et al, 1979;Hollenberg et al, 1981;McNabb et al, 1986;Navis et al, 1986). Captopril and enalapril cause acute natriuresis (Brunner et al, 1981;Hollenberg et al, 1981;McNabb et al, 1986;Navis et al, 1986) which may be accompanied by potassium retention (Atlas et al, 1979;Navis et al, 1986) or in the case of enalapril by kaliuresis (McNabb et al, 1985(McNabb et al, , 1986. Both drugs have been reported to increase prostaglandin levels (Swartz et al, 1980;Oparil et al, 1983) but there are no data for cilazapril.…”

Section: Introductionmentioning

confidence: 99%

The effects of cilazapril alone and in combination with frusemide in healthy subjects.

Johnston

Passmore

1989

Brit J Clinical Pharma

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1. In a fourway double‐blind placebo controlled study, the effects of cilazapril, a new angiotensin converting enzyme inhibitor, on renal function and the responses to intravenous frusemide were studied in a group of twelve salt depleted male volunteers. 2. Cilazapril produced an increase in effective renal plasma flow and urinary output of prostaglandin E2 metabolite (PGE2‐M) but no effect on sodium, potassium or water excretion. 3. Pretreatment with cilazapril antagonised the effects of frusemide on glomerular filtration, PGE2‐M and sodium excretion.

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“…Enalkiren was delivered intravenously over 90 minutes at a dose of 0.5 mg/kg, shown to be at the top of the dose-response curve for renal vasodilation. 9 On a third study day, captopril was delivered as a 25-mg pill, also known to be at the top of the renal vasodilator dose-response curve, 15 followed by placebo infusion, both single-blind.…”

mentioning

confidence: 99%

Responses to converting enzyme and renin inhibition. Role of angiotensin II in humans.

et al. 1994

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We compared the renal vascular responses to angiotensin converting enzyme inhibition and renin inhibition to assess the influence of angiotensin II (Ang II). We examined the renal and endocrine responses to the renin inhibitor enalkiren, to captopril, and to placebo in nine healthy and nine hypertensive men on a 10-mmol sodium diet. Ang II was infused to assess effects of the agents on renal and adrenal responsiveness to Ang II. Plasma Ang II concentration was suppressed similarly with enalkiren and captopril -an identical level of blockade was achieved. Although renal plasma flow was stable during placebo, a substantial rise was seen with both enalkiren (+133±26 mL/min per 1.73 m 2

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Sodium intake and renal responses to captopril in normal man and in essential hypertension

Cited by 164 publications

References 18 publications

Acute effects of combined vasodilation and beta‐adrenoceptor blockade with prizidilol on renal function.

Acute effects of combined vasodilation and beta‐adrenoceptor blockade with prizidilol on renal function.

The effects of cilazapril alone and in combination with frusemide in healthy subjects.

Responses to converting enzyme and renin inhibition. Role of angiotensin II in humans.

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