2018
DOI: 10.1152/ajprenal.00099.2018
|View full text |Cite
|
Sign up to set email alerts
|

Sodium intake but not renal nerves attenuates renal venous pressure-induced changes in renal hemodynamics in rats

Abstract: Increased central venous pressure and renal venous pressure (RVP) are associated with worsening of renal function in acute exacerbation of congestive heart failure. We tested whether an acute isolated elevation of RVP in one kidney leads to ipsilateral renal vasoconstriction and decreased glomerular filtration rate (GFR) and whether this depends on dietary salt intake or activation of renal nerves. Male Lewis rats received a normal (1% NaCl, NS) or high-salt (6% NaCl) diet for ≥14 days before the acute experim… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
14
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 6 publications
(15 citation statements)
references
References 20 publications
1
14
0
Order By: Relevance
“…Baseline MAP did not differ among the three groups ( Figure 1A ). We had previously observed that an increase in RVP to 20mmHg did not significantly affect MAP, but decreased HR (this control is included in Figures 1B , D ; Huang et al 2018 ). In ANG II Clamp animals, an acute increase of RVP to 20mmHg induced a gradual reduction in MAP from 102±1 to 78±5mmHg ( p <0.05; Figure 1B ) and also a decrease in HR from 359±5 to 337±8bpm ( p <0.05; Figure 1D ).…”
Section: Resultsmentioning
confidence: 66%
See 2 more Smart Citations
“…Baseline MAP did not differ among the three groups ( Figure 1A ). We had previously observed that an increase in RVP to 20mmHg did not significantly affect MAP, but decreased HR (this control is included in Figures 1B , D ; Huang et al 2018 ). In ANG II Clamp animals, an acute increase of RVP to 20mmHg induced a gradual reduction in MAP from 102±1 to 78±5mmHg ( p <0.05; Figure 1B ) and also a decrease in HR from 359±5 to 337±8bpm ( p <0.05; Figure 1D ).…”
Section: Resultsmentioning
confidence: 66%
“…Increased RVP induced HR reduction in untreated control group and ANG II Clamp group ( * p <0.05) but not in the ANG II Absent group (D) . #Data from these were published in Huang et al (2018) .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Concomitant renovascular disease or treatment with renin–angiotensin–aldosterone system inhibitors and nonsteroidal anti‐inflammatory drugs may further interfere with maintenance of GFR. Of note, rat models suggest that hormonal factors may also be involved in the decrease of GFR, implicating pathways other than a simple reduction of the renal arteriovenous pressure gradient 87 …”
Section: Congestive Nephropathymentioning
confidence: 99%
“…Of note, rat models suggest that hormonal factors may also be involved in the decrease of GFR, implicating pathways other than a simple reduction of the renal arteriovenous pressure gradient. 87…”
Section: Chronic Kidney Disease and Pulmonary Hypertensionmentioning
confidence: 99%