Sodium Lactate Elicits a Rapid Increase in Blood Pressure in Wistar Rats and Spontaneously Hypertensive Rats Effect of Pretreatment with the Antipanic Drugs Clomipramine and Alprazolam

Wikander, Ida; Roos, Tomas; Stakkestad, Anna; Eriksson, Elias

doi:10.1016/0893-133x(94)00082-b

Cited by 10 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have previously shown that the cardiovascular response to lactate is more pronounced in Wistar rats than in Sprague-Dawley rats (Wikander et al 1995); tentatively, the difference between our results and those of Shekhar and co-workers with respect to effects of lactate on respiration could thus be due to the use of different strains. Previous literature does support the notion that rats of Wistar strains (including Wistar-Kyoto) and Sprague-Dawley rats differ with respect to various aspects of behavior, (Galan et al 1994;LopezRubalcava and Lucki 2000;Pilz et al 1999;Shoaib et al 1995) and also that chemoreceptor responsiveness may be higher in Wistar-Kyoto rats than in rats of the Sprague-Dawley strain (Hayward et al 1999).…”

Section: Discussioncontrasting

confidence: 82%

“…Supporting this concept, an anxiety-provoking effect similar to that of lactate has been observed after inhalation of CO 2 in panic disorder subjects and in women with premenstrual dysphoria (Gorman et al , 1988aGriez et al 1987;Harrison et al 1989;Kent et al 2001;Papp et al 1997;Perna et al 1994;Woods et al 1986). We have previously reported that intravenous administration of sodium lactate to Wistar rats, but not to rats of the Sprague-Dawley strain, elicits an increase in blood pressure and variable effects on heart rate (Wikander et al 1995). Such cardiovascular response is in line with the assumption that lactate induces a stimulation of central or peripheral chemoreceptors.…”

supporting

confidence: 62%

“…We have previously reported that intravenous administration of sodium lactate to Wistar rats, but not to rats of the Sprague-Dawley strain, elicits an increase in blood pressure and variable effects on heart rate (Wikander et al 1995). Such cardiovascular response is in line with the assumption that lactate induces a stimulation of central or peripheral chemoreceptors.…”

supporting

confidence: 62%

See 2 more Smart Citations

Respiratory Responses to Intravenous Infusion of Sodium Lactate in Male and Female Wistar Rats

Olsson

Annerbrink

et al. 2002

Neuropsychopharmacology

View full text Add to dashboard Cite

In patients with panic disorder or premenstrual dysphoria, anxiety attacks can be triggered by intravenous administration of sodium lactate. Since respiratory symptoms, such as hyperventilation and shortness of breath, are characteristic features of spontaneous as well as lactate-induced panic, an involvement of central or peripheral chemoreceptors in this reactionIn patients with panic disorder (Liebowitz et al. , 1985Pitts and McClure 1967) or premenstrual dysphoria (Facchinetti et al. 1992;Sandberg et al. 1993), but not in healthy controls, intravenous (i.v.) administration of sodium lactate elicits an anxiety reaction strongly resembling spontaneous panic attacks. The anxiogenic effect of sodium lactate has been attributed to changes in calcium concentrations (Pitts and McClure 1967), pH (Grosz andFarmer 1972), redox activity (Carr et al. 1986), pCO 2 (Gorman et al. 1988a), and osmolarity (Jensen et al. 1991;Peskind et al. 1998). However, all these theories and findings have also been questioned, and the mechanism by which sodium lactate elicits panic attacks hence is as yet unexplained.Likewise, the reason why patients with panic disorder or premenstrual dysphoria differ from controls with respect to sensitivity to lactate is a matter of controversy. Notably, a more rapid and substantial rise in brain lactate has been observed in panic patients as compared with control subjects (Dager et al. 1999), but the difference between patients and controls may also be due to different responsiveness to a given concentration (Pohl et al. 1994;Rifkin et al. 1981).Panic attacks are almost always associated with hyperventilation and respiratory discomfort, such as shortness of breath; it has thus been suggested that lactate-induced as well as spontaneous panic attacks may be due to an activation of a hyperresponsive suffocation alarm system involving activation of central or peripheral chemoreceptors (Klein 1993). Supporting this concept, an anxiety-provoking effect similar to that of lactate has been observed after inhalation of CO 2 in panic disorder subjects and in women with premenstrual dysphoria (Gorman et al. , 1988aGriez et al. 1987;Harrison et al. 1989;Kent et al. 2001;Papp et al. 1997;Perna et al. 1994;Woods et al. 1986).We have previously reported that intravenous administration of sodium lactate to Wistar rats, but not to rats of the Sprague-Dawley strain, elicits an increase in blood pressure and variable effects on heart rate (Wikander et al. 1995). Such cardiovascular response is in line with the assumption that lactate induces a stimulation of central or peripheral chemoreceptors. In the present study, the effect of sodium lactate on respiratory rate and tidal volume in freely moving, unrestrained male and female rats of the Wistar strain was explored. Given the previous reports suggesting that spontaneous panic attacks are menstrual cycle-dependent (Basoglu et al. 2000;Breier et al. 1986;Cameron et al. 1988;Cook et al. 1990;Klein 1993), that panic disorder may improve during pregnancy (Hertzberg and Wa...

show abstract

Section: Discussioncontrasting

confidence: 82%

supporting

confidence: 62%

supporting

confidence: 62%

See 1 more Smart Citation

Respiratory Responses to Intravenous Infusion of Sodium Lactate in Male and Female Wistar Rats

Olsson

Annerbrink

et al. 2002

Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…We recently found that spontaneously hypertensive (SH) rats are more reactive than other rat strains to stimuli causing anxiety attacks in panic disorder patients (such as sodium lactate and yohimbine) (see Wikander et al 1995); hence, we also used SH rats for experiments on the mechanism of action of mCPP. Therefore, most of the microdialysis experiments presented in this paper were performed on SH rats; however, for the electrophysiological studies, and for some of the microdialysis experiments, rats of the Sprague-Dawley (SD) strain were used.…”

Section: Intravenous Administration Of M-chloro-phenylpiperazine (Mcpmentioning

confidence: 99%

“…The observations that mCPP may aggravate psychotic symptoms in schizophrenic patients and cause elation in cocaine addicts-in conjunction with the data of Benloucif and Galloway (1991) suggesting that local administration of mCPP within the striatum of anesthetized rats leads to a marked increase in dopamine releaseprompted us to investigate to what extent extracellular levels of dopamine in awake rats are influenced by systemic administration of mCPP. In addition, the effect of mCPP on the firing rate of dopaminergic neurons was investigated.We recently found that spontaneously hypertensive (SH) rats are more reactive than other rat strains to stimuli causing anxiety attacks in panic disorder patients (such as sodium lactate and yohimbine) (see Wikander et al 1995); hence, we also used SH rats for experiments on the mechanism of action of mCPP. Therefore, most of the microdialysis experiments presented in this paper were performed on SH rats; however, for the electrophysiological studies, and for some of the microdialysis experiments, rats of the Sprague-Dawley (SD) strain were used.…”

mentioning

confidence: 99%

Effects of mCPP on the Extracellular Concentrations of Serotonin and Dopamine in Rat Brain

Eriksson

Engberg²,

Bing³

et al. 1999

Neuropsychopharmacology

View full text Add to dashboard Cite

Intravenous administration of m-chloro-phenylpiperazine (mCPP) (0.25 or 2.5 mg/kg) induced a marked and doserelated increase in extracellular concentrations of serotonin in hippocampus (300-1,400% of baseline) as measured using in vivo microdialysis in awake male Wistar rats of the spontaneously hypertensive (SH) strain. Indicating that the effect of mCPP was caused by a reversal of the serotonin transporter, it was antagonized by pretreatment with the serotonin re-uptake inhibitor citalopram (10 mg/kg) but was unaffected by local administration of the sodium channel blocker tetrodotoxin (TTX; 1 m). mCPP was also shown to induce an increase in extracellular concentrations of dopamine in the nucleus accumbens and the striatum of SH rats and in the nucleus accumbens of rats of the Sprague-Dawley (SD) Dopamine, In vivo microdialysis; Hippocampus; Striatum, Nucleus accumbens; Citalopram; Rat m-Chloro-phenylpiperazine (mCPP), the metabolite of the antidepressant drug trazodone, has recently gained marked attention as a putative probe of serotonergic function in clinical psychiatric research. Thus, the prolactin, ACTH, and cortisol responses to mCPP frequently have been used as putative markers of postsynaptic serotonin receptor function in various psychiatric disorders. Moreover, administration of mCPP has been shown to elicit, and/or aggravate, anxiety attacks in patients with panic disorder, obsessions in patients with obsessive compulsive disorder (OCD), elation in alcoholics and cocaine addicts, and positive symptoms in schizophrenic patients (see Murphy et al. 1991;Kahn and Wetzler 1991;Krystal et al. 1993;Buydens-Branchey et al. 1993;Krystal et al. 1994).mCPP displays high affinity to 5-HT2C receptors and moderate, or low, affinity to 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT3 receptors; in addition, the compound has some affinity for alpha-2-adrenoceptors. At the 5-HT2C receptor, mCPP seems to act as a partial agonist with relatively high intrinsic efficacy, whereas, at the other serotonin receptors, the intrinsic efficacy of mCPP is moderate or low (see Murphy et al. 1991 NO . 3 and Wetzler 1991). The behavioral and endocrine effects of mCPP observed in clinical studies are generally attributed to the direct effects of mCPP on various subtypes of serotonin receptors; in contrast, little attention has been paid to the report by Baumann et al. (1993) suggesting that mCPP may also stimulate serotonin release by means of an interaction with the serotonin transporter (see also Baumann et al. 1995).To further elucidate the possible influence of mCPP on the release of serotonin, we studied the effects of a high dose of mCPP on extracellular, hippocampal concentrations of serotonin in awake, freely moving rats using in vivo microdialysis.Enhanced dopaminergic neurotransmission has been suggested as a mechanism of importance both for the positive symptoms of schizophrenia and for the euphoria induced by such central stimulants as cocaine. The observations that mCPP may aggravate psychotic symptoms in schizophr...

show abstract

Production of panic-like symptoms by lactate is associated with increased neural firing and oxidation of brain redox in the rat hippocampus

Bergold

Pinkhasova

Syed

et al. 2009

Neuroscience Letters

View full text Add to dashboard Cite

Sodium Lactate Elicits a Rapid Increase in Blood Pressure in Wistar Rats and Spontaneously Hypertensive Rats Effect of Pretreatment with the Antipanic Drugs Clomipramine and Alprazolam

Cited by 10 publications

References 29 publications

Respiratory Responses to Intravenous Infusion of Sodium Lactate in Male and Female Wistar Rats

Respiratory Responses to Intravenous Infusion of Sodium Lactate in Male and Female Wistar Rats

Effects of mCPP on the Extracellular Concentrations of Serotonin and Dopamine in Rat Brain

Production of panic-like symptoms by lactate is associated with increased neural firing and oxidation of brain redox in the rat hippocampus

Contact Info

Product

Resources

About