Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients

Şahin, Ayşe; Er, Elif Öztürk; Öz, Ersoy; Yıldırmak, Zeynep Yıldız; Bakırdere, Sezgin

doi:10.1007/s12011-020-02217-5

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…Iron overload leads to accumulation of iron, tissue damage, increased oxidative stress and storage capacity. This result matches other studies (10,11,12) . The same iron level increasing was observed in SCA-Thal patients, but with less severity, because these patients suffer from metabolic regulation, cell damage, and chronic hypoxia, which leads to ineffective erythropoiesis, hemolysis and anemia (11) .…”

Section: Resultssupporting

confidence: 93%

“…Calcium serum level decreasing in the two diseased groups compared to the control group, this can be attributed to low level of parathyroid hormone and deficiency of vitamin D, this agree with other studies (16,17,12) . Magnesium plays an important role in activating many enzymes, as it helps the muscles, nerves and heart function properly.…”

Section: Resultssupporting

confidence: 90%

“…The serum Manganese level, showed non-significant behaviour in patients with thalassemia, while it showed a high significant behaviour in patients with SCA-Thal compared to the control group as (total, male and female) numbers. Manganese level is decreased in patients with SCA-Thal, which can be attributed to the oxidative stress, due to the over production of free radicals through a secondary iron (12) .…”

Section: Resultsmentioning

confidence: 99%

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Investigation of Some Trace Elements levels Antioxidants in Patients with Thalassemia Major and Sickle Cell AnemiaThalassemia in South of Iraq

Qais R. Lahhob,

Nidhal Y. Mohammed,

Hamid J. Abbas

2021

Indian Journal of Forensic Medicine & Toxicology

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Back ground: Thalassemia major) THM( is the most common single gene disorder. It is a hereditary blood disease characterized by reduced or absent production of beta globin chains. For the patients with SCA-Thal, they have two mutations (sickle cell anemia and thalassemia). The ratio of minerals and trace elements in the patients' blood played an important role in many biological processes. This study aims to measure the level of seven elements, Fe, Mn, Ca +2 , Mg, P, Cr, Co and three another antioxidant element (Zn, Cu &Se) in the blood of THM and SAC-thal patients. Results:In THM and SCA-Thal patients, antioxidant elements (Cu, Zn & Se), showed highly significant behaviour when compared to each other and with the control group as total patient population, and as (total, male and female) numbers. In thalassemia patients, Fe, P & Co also showed highly significant behaviour, while Ca + 2 behaviour was not significant for male numbers only. Elemental Mg & Cr, demonstrated insignificant behaviours. In SCA-Thal patients, Mn & Ca + 2 showed highly significant behaviour, while, Fe showed a non-significant behaviour relative to male numbers only, and Mg, P, Cr & Co showed nonsignificant behaviour. Conclusion:The study revealed the similarity of antioxidant elements behaviour in both diseases, as well as the statistical behaviour of all elements when compared with the control group for these diseases.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

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Investigation of Some Trace Elements levels Antioxidants in Patients with Thalassemia Major and Sickle Cell AnemiaThalassemia in South of Iraq

Qais R. Lahhob,

Nidhal Y. Mohammed,

Hamid J. Abbas

2021

Indian Journal of Forensic Medicine & Toxicology

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“…Studies in the recent past have established higher incidence of hypercalcuria and lower levels of calcium in patients affected with beta thalassaemia 18 19. One interesting and relatively new finding of elevated serum calcium levels was seen in our study.…”

Section: Discussionsupporting

confidence: 79%

Burden of ocular abnormalities in patients with beta thalassaemia: a cross-sectional study

Baig

Zahid

et al. 2023

BMJ Open Ophth

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IntroductionIn Pakistan, the reported carrier rate of thalassaemia is estimated to be 5%–8% with 5000 new patients diagnosed every year. Several known systemic complications of beta thalassaemia major have been studied, but no studies are conducted to assess ocular complications among these patients from our population.MethodsIt was a cross-sectional study design conducted at three private and public sector centres in Pakistan. We recruited 203, 11–17 years old children with beta thalassaemia major in our study. Frequency of overall ocular complications such as retinal pigment epithelium degeneration, visual field defects, increased retinal vascular tortuosity, lenticular opacities, anterior segment abnormality, etc among beta thalassaemia patients were verified by an ophthalmologist.ResultsOn univariate analysis male gender (prevalence ratio (PR): 1.023 (0.903 to 1.160), OGTT levels (PR: 0.99 (0.978 to 1.003) and serum calcium levels (PR: 0.716 (0.616 to 0.936)) were significantly associated with ocular complications. However, on multivariable analysis after adjusting for covariates we observed that the prevalence of ocular complications was 88% higher in males as compared with females. Moreover, with every one unit increase in serum calcium levels the prevalence of ocular complications were decreased by 24%.ConclusionOur study results showed that the frequency of ocular complications in beta thalassaemia children was 22.7%. Male gender was a risk factor for ocular complications among children with beta thalassaemia. However, high calcium levels among these patients were found to be protective for ocular complications.

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“…Fahmy et al38 observed a negative correlation between serum magnesium and serum ferritin suggesting an inverse association with iron overload. Recently, Sahin et al39 found 41 Turkish patients with transfusion-dependent beta Thal had elevated serum magnesium in comparison to age-matched and sex-matched controls. Incidentally, iron, zinc, and manganese were also significantly elevated in this cohort.…”

Section: Resultsmentioning

confidence: 99%

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

Goldberg¹,

Lal

Fung

2021

Journal of Pediatric Hematology/Oncology

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Background: Reports of nutritional deficiencies in patients with thalassemia (Thal) are common. Despite its importance, however, nutritionally focused research in Thal has been limited by inadequate sample size, inconsistent methodology, a lack of control comparisons, and few interventional trials. Due to these limitations, clinicians lack evidence-based nutrition recommendations to support clinical decision-making. This systematic review summarizes observed relationships between nutrition and morbidity in Thal published in the last 3 decades.Methods: PubMed, Web of Science, and Embase were screened for articles pertaining to nutrition in Thal using comprehensive search terms. Studies performed in humans, written in English, and published between 1990 and 2020 were included. Over 2100 manuscripts were identified, from which 97 were included.Results: Patients with Thal were most often deficient in vitamins A, C, D, selenium, and zinc. Prevalence of nutritional deficiency was positively correlated with age and iron overload. Evidence to support the role of vitamin D and zinc for bone health was observed; zinc was also found to improve glucose metabolism.Conclusions: Due to the risk for multinutrient deficiency, nutritional status should be assessed annually in patients with Thal with prompt nutrient replacement when deficiency is detected. Routine supplementation with vitamin D and zinc is recommended.

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Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients

Cited by 11 publications

References 35 publications

Investigation of Some Trace Elements levels Antioxidants in Patients with Thalassemia Major and Sickle Cell AnemiaThalassemia in South of Iraq

Investigation of Some Trace Elements levels Antioxidants in Patients with Thalassemia Major and Sickle Cell AnemiaThalassemia in South of Iraq

Burden of ocular abnormalities in patients with beta thalassaemia: a cross-sectional study

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

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