Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma

Schepkin, Victor D.; Ross, Brian D.; Chenevert, Thomas L.; Rehemtulla, Alnawaz; Sharma, Surabhi; Kumar, Mayank; Stojanovska, Jadranka

doi:10.1002/mrm.20332

Cited by 67 publications

(86 citation statements)

References 32 publications

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“…Both fat : water ratios (Jagannathan et al, 1998) and choline levels (Preul et al, 2000;Jagannathan et al, 2001;Schwarz et al, 2002;Meisamy et al, 2004) have also been used to monitor treatment-induced changes, and phosphorous MRS has been used to predict response using differences in the levels of phosphocholine or phosphomonoesters (Shukla-Dave et al, 2002a, b;Arias-Mendoza et al, 2004). Sodium MRI might also be useful in monitoring treatment response (Kline et al, 2000;Schepkin et al, 2005).…”

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confidence: 99%

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

et al. 2006

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A prospective study was undertaken in women undergoing neoadjuvant chemotherapy for locally advanced breast cancer in order to determine the ability of quantitative magnetic resonance imaging (MRI) and proton spectroscopy (MRS) to predict ultimate tumour response (percentage decrease in volume) or to detect early response. Magnetic resonance imaging and MRS were carried out before treatment and after the second of six treatment cycles. Pharmacokinetic parameters were derived from T 1 -weighted dynamic contrast-enhanced MRI, water apparent diffusion coefficient (ADC) was measured, and tissue water : fat peak area ratios and water T 2 were measured using unsuppressed one-dimensional proton spectroscopic imaging (30 and 135 ms echo times). Pharmacokinetic parameters and ADC did not detect early response; however, early changes in water : fat ratios and water T 2 (after cycle two) demonstrated substantial prognostic efficacy. Larger decreases in water T 2 accurately predicted final volume response in 69% of cases (11/16) while maintaining 100% specificity and positive predictive value. Small/absent decreases in water : fat ratios accurately predicted final volume non-response in 50% of cases (3/6) while maintaining 100% sensitivity and negative predictive value. This level of accuracy might permit clinical application where early, accurate prediction of non-response would permit an early change to second-line treatment, thus sparing patients unnecessary toxicity, psychological morbidity and delay of initiation of effective treatment.

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confidence: 99%

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

et al. 2006

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“…Single and multiple quantum sodium NMR has been used extensively to study various biological tissues such as brain (89,90,104,(116)(117)(118)(119)(120), breast (121) heart (122)(123)(124)(125)(126)(127)(128), muscle (129,130), tumors (131)(132)(133), blood (122) and cartilage (27,93,(134)(135)(136) and reviewed in several articles (86,87,91,108,119,(137)(138)(139)(140)(141). In this review, however, we restrict our discussion to sodium NMR of cartilage.…”

Section: Multiple Quantum Filtered (Mqf) Nmrmentioning

confidence: 99%

Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

et al. 2006

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In this article, both sodium magnetic resonance (MR) and T 1r relaxation mapping aimed at measuring molecular changes in cartilage for the diagnostic imaging of osteoarthritis are reviewed. First, an introduction to structure of cartilage, its degeneration in osteoarthritis (OA) and an outline of diagnostic imaging methods in quantifying molecular changes and early diagnostic aspects of cartilage degeneration are described. The sodium MRI section begins with a brief overview of the theory of sodium NMR of biological tissues and is followed by a section on multiple quantum filters that can be used to quantify both bi-exponential relaxation and residual quadrupolar interaction. Specifically, (i) the rationale behind the use of sodium MRI in quantifying proteoglycan (PG) changes, (ii) validation studies using biochemical assays, (iii) studies on human OA specimens, (iv) results on animal models and (v) clinical imaging protocols are reviewed. Results demonstrating the feasibility of quantifying PG in OA patients and comparison with that in healthy subjects are also presented. The section concludes with the discussion of advantages and potential issues with sodium MRI and the impact of new technological advancements (e.g. ultra-high field scanners and parallel imaging methods). In the theory section on T 1r , a brief description of (i) principles of measuring T 1r relaxation, (ii) pulse sequences for computing T 1r relaxation maps, (iii) issues regarding radio frequency power deposition, (iv) mechanisms that contribute to T 1r in biological tissues and (v) effects of exchange and dipolar interaction on T 1r dispersion are discussed. Correlation of T 1r relaxation rate with macromolecular content and biomechanical properties in cartilage specimens subjected to trypsin and cytokineinduced glycosaminoglycan depletion and validation against biochemical assay and histopathology are presented. Experimental T 1r data from osteoarthritic specimens, animal models, healthy human subjects and as well from osteoarthritic patients are provided. The current status of T 1r relaxation mapping of cartilage and future directions is also discussed. Copyright # 2006 John Wiley & Sons, Ltd. KEYWORDS: cartilage; arthritis; spin-lock; T1rho; sodium; MRI OSTEOARTHRITIS Osteoarthritis (OA) affects more than half of the population above the age of 65 (1,2) and has a significant negative impact on the quality of life of elderly individuals (3). The economic costs in the USA from OA have been estimated to be more than 1% of the gross domestic product (4). OA is now increasingly viewed as a metabolically active joint disorder of diverse etiologies. The biochemistry of the disease is characterized by the following changes in cartilage: reduced proteoglycan (PG) concentration, possible changes in the size of collagen fibril and aggregation of PG, increased water content and increased rate of synthesis and degradation of matrix macromolecules. The earliest changes in the cartilage due to OA result in a partial breakdown in the proteoglyc...

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“…Using this technique, a TE of 853 μs was achieved, which helped to minimise T 2 -weighting effects on the measured signal intensity.T 1 -weighting effects were also minimised through the use of a relatively long TR of 200 ms, considering that the T 1 for 23 Na in vivo is in the region of 40 ms [11,12]. Typical TR values quoted in the literature for Na-MRI range from 100 to 120 ms, aimed primarily at maximising the SNR through the use of multiple signal averaging within a reasonable acquisition time [13,14].…”

Section: In Vivo Mr Image Acquisition and Reconstructionmentioning

confidence: 99%

A double-tuned¹H/²³Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI

et al. 2010

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Abbreviations MRImagnetic resonance imaging SNR signal-to-noise ratio AbstractA method for quantifying the Tissue Sodium Concentration (TSC) in the rat brain from 23 Na-MR images was developed. TSC is known to change in a variety of common human diseases and holds considerable potential to contribute to their study;however, its accurate measurement in small laboratory animals has been hindered by the extremely low signal to noise ratio (SNR) in 23 Na images. To address this, the design, construction and characterisation of a double-tuned 1 H/ 23 Na dual resonator system for 1 H-guided quantitative 23 Na-MRI is described. This system comprised of an SNR-optimised surface detector coil for 23 Na image acquisition, and a volume resonator producing a highly-homogeneous B 1 field (<5% inhomogeneity) for the Na channel across the rat head. The resonators incorporated channel-independent balanced matching and tuning capabilities with active decoupling circuitry at the 23 Na resonance frequency. A quantification accuracy of TSC of < 10mM was achieved in Na-images with 1.2µl voxel resolution acquired in 10 minutes. The potential of the quantification technique was demonstrated in an in vivo experiment of a rat model of cerebral stroke, where the evolution of the TSC was successfully monitored for 8 hours after the stroke was induced.

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Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma

Cited by 67 publications

References 32 publications

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

A double-tuned¹H/²³Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI

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Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma

Cited by 67 publications

References 32 publications

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

Sodium and T1ρ MRI for molecular and diagnostic imaging of articular cartilage

A double-tuned1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI

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Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

A double-tuned¹H/²³Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI