Sodium MR Imaging Detection of Mild Alzheimer Disease: Preliminary Study

Mellon, Eric A.; Pilkinton, David T.; Clark, Christopher; Elliott, Mark A.; Witschey, Walter R.; Borthakur, Arijitt; Reddy, Ravinder

doi:10.3174/ajnr.a1495

Cited by 102 publications

(90 citation statements)

References 60 publications

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“…The potential diagnostic benefits of 23 Na-MR imaging have recently been demonstrated for common pathological conditions such as tumor [5,6], stroke [7][8][9], Alzheimer disease [10], paramyotonia [11], arthritis [12], multiple sclerosis [13] and functional renal imaging [14] in humans. In addition, pre-clinical in vivo 23 Na MRI enables one to temporally follow pathological progression in animal models of common human disease [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

Wetterling

Högler

Molkenthin

et al. 2012

Journal of Magnetic Resonance

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The design and construction of a two-port surface transceiver resonator for both 1 H-and 23 Na-MRI in the rodent brain at 7T is described. Double-tuned resonators are required for accurately co-registering multi-nuclei data sets, especially when the time courses of 1 H and 23 Na signals are of interest as, for instance, when investigating the pathological progression of ischaemic stroke tissue in vivo. In the current study, a single-element two-port surface resonator was developed wherein both frequency components were measured with the same detector element but with each frequency signal routed along different output channels.This was achieved by using the null spot technique, allowing for optimal variable tuning and matching of each channel in situ within the MRI scanner. The 23 Na signal to noise ratio, measured in the ventricles of the rat brain, was increased by a factor of four compared to recent state-of-the-art rat brain studies reported in the literature. The resonator's performance was demonstrated in an in vivo rodent stroke model, where regional variations in 1 H apparent diffusion coefficient maps and the 23 Na signal were recorded in an interleaved fashion as a function of time in the acute phase of the stroke without having to exchange, re-adjust, or re-connect resonators between scans. Using the practical construction steps described in this paper, this coil design.

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Section: Introductionmentioning

confidence: 99%

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

Wetterling

Högler

Molkenthin

et al. 2012

Journal of Magnetic Resonance

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“…Other MR imaging techniques, such as sodium MR imaging, can detect differences between a patient with mild AD and controls, which correlate with hippocampal volume. 80 While these methods hold promise, unlike hippocampal atrophy on structural MR imaging, none are yet recognized or validated as an AD biomarker for the purposes of diagnosis or clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Imaging Approaches for Dementia

Murray

2011

AJNR Am J Neuroradiol

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SUMMARY:Brain imaging has progressed from exclusion of rare treatable mass lesions to a specific antemortem diagnosis. MR imagingϪderived hippocampal atrophy and WMH are regarded as imaging biomarkers of AD and CVD respectively. Abnormal FP-CIT SPECT or cardiac iodobenzamide SPECT is a useful supportive imaging feature in the diagnosis of DLB. Frontal and/or anterior temporal atrophy and anterior defects on molecular imaging with FDG-PET or perfusion SPECT are characteristic of FTDs. Whole-body FDG-PET may be helpful in patients with rapidly progressing "autoimmune dementias," and FLAIR and DWI are indicated in suspected CJD. A major role of imaging is in the development of new drugs and less costly biomarkers.ABBREVIATIONS: apoE ϭ apolipoprotein E; APP ϭ amyloid precursor protein; bvFTD ϭ behavior variant frontotemporal dementia; CJD ϭ Creutzfeldt-Jacob disease; CVD ϭ cerebrovascular disease; DLB ϭ dementia with Lewy bodies; FP-CIT ϭ iodine-123-␤-carbomethoxy-3 ␤-(4-iodophenyltropane) fluoropropyl; FTD ϭ frontotemporal dementia; MCI ϭ mild cognitive impairment; PD ϭ Parkinson disease; rCBF ϭ regional cerebral blood flow; sCJD ϭ sporadic Creutzfeldt-Jacob disease; TDP ϭ TAR deoxyribonucleic acidϪbinding protein 43; VBM ϭ voxel-based morphometry; vCJD ϭ variant Creutzfeldt-Jacob disease; WMH ϭ white matter hyperintensities

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“…The IVF and TCF bioscales inform on cell packing and cell density which have been shown to be informative in clinical settings of tissue viability in stroke (Thulborn et al, 1999;Boada et al, 2005) and brain tumor response to radiation and chemotherapy (Thulborn et al, accepted for publication; Kline et al, 2000). Current investigations suggest that the TSC, IVF, and TCF bioscales may reflect regional changes in sodium concentration in early neurodegenerative diseases (Mellon et al, 2009;.…”

Section: Introductionmentioning

confidence: 96%

Rapid computation of sodium bioscales using gpu‐accelerated image reconstruction

Atkinson¹,

Li²,

Obeid³

et al. 2013

Int J Imaging Syst Tech

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Quantitative sodium magnetic resonance imaging permits noninvasive measurement of the tissue sodium concentration (TSC) bioscale in the brain. Computing the TSC bioscale requires reconstructing and combining multiple datasets acquired with a nonCartesian acquisition that highly oversamples the center of k-space. Even with an optimized implementation of the algorithm to compute TSC, the overall processing time exceeds the time required to collect data from the human subject. Such a mismatch presents a challenge for sustained sodium imaging to avoid a growing data backlog and provide timely results. The most computationally intensive portions of the TSC calculation have been identified and accelerated using a consumer graphics processing unit (GPU) in addition to a conventional central processing unit (CPU). A recently developed data organization technique called Compact Binning was used along with several existing algorithmic techniques to maximize the scalability and performance of these computationally intensive operations. The resulting GPU1CPU TSC bioscale calculation is more than 15 times faster than a CPU-only implementation when processing 256 3 256 3 256 data and 2.4 times faster when processing 128 3 128 3 128 data. This eliminates the possibility of a data backlog for quantitative sodium imaging. The accelerated quantification technique is suitable for general three-dimensional non-Cartesian acquisitions and may enable more sophisticated imaging techniques that acquire even more data to be used for quantitative sodium imaging.

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Sodium MR Imaging Detection of Mild Alzheimer Disease: Preliminary Study

Cited by 102 publications

References 60 publications

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

Imaging Approaches for Dementia

Rapid computation of sodium bioscales using gpu‐accelerated image reconstruction

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