Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties

Yang, Jwu Mau; Tang, Chaohua; Yu, Kwong Leung; Yang, Yu; Chang, Wen Chang; Chen, Ing Jun

doi:10.1016/0306-3623(95)00086-0

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…In mice and rats capsaicin produced a dosedependent prolongation of bleeding time and inhibited platelet aggregation (9,10). In Thai people who ate hot peppers daily, capsaicin induced an increase in fibrinolytic activity (11).…”

Section: Commentmentioning

confidence: 99%

Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis

Yosipovitch

Mengesha

Facliaru³

et al. 2005

Journal of Dermatological Treatment

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Topical capsaicin is well known to reduce nociceptive pain and neurogenic inflammation by depleting substance P. Its fibrinolytic and antithrombotic effects are less well known. We report two cases of acute lipodermatosclerosis which did not respond to several conventional treatment regimens and one case of acute lobular panniculitis in a pregnant woman with venous insufficiency, who were successfully treated within a short period of 3 weeks with topical 0.075% capsaicin cream.

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Section: Commentmentioning

confidence: 99%

Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis

Yosipovitch

Mengesha

Facliaru³

et al. 2005

Journal of Dermatological Treatment

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“…Sodium nonivamide acetate (SNA; C 19 H 28 NO 5 Na) is a derivative of capsaicin synthesized by alkylation of the phenolic hydroxyl group of nonivamide with bromoacetic acid Yang et al, 1996]. The antinociceptive potency of this sodium salt was 1.75 and 27.5 times greater than that of capsaicin and indomethacin [Chen et al, 1992].…”

Section: Introductionmentioning

confidence: 99%

Transdermal iontophoresis of sodium nonivamide acetate evaluated by in vivo microdialysis and histologic study

et al. 1999

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Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus

Kargutkar

Brijesh

2017

Inflammopharmacol

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Ananas comosus (L.) Merr (Pineapple) is a tropical plant with an edible fruit. In the present study, the potential anti-inflammatory activity of A. comosus leaf extract (ALE) was studied. ALE prepared using soxhlet apparatus was subjected to preliminary qualitative phytochemical analysis and quantitative estimations of flavonoids and tannins. The components present in ALE were identified using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). Inhibitory effects of ALE on protein denaturation, and proteinase activity were assessed. Its effect on secretion of pro-inflammatory cytokines and inflammatory mediators by lipopolysaccharide-stimulated macrophages was also analyzed. Further, its anti-inflammatory activity in carrageenan-induced inflammatory rat model was examined. The preliminary qualitative phytochemical analysis revealed presence of flavonoids, phenols, tannins, carbohydrates, glycosides, and proteins in the extract. Total flavonoids and total tannins were 0.17 ± 0.006 mg equivalent of quercetin/g of ALE and 4.04 ± 0.56 mg equivalent of gallic acid/g of ALE. LC-MS analysis identified the presence of 4-hydroxy pelargonic acid, 3,4,5-trimethoxycinnamic and 4-methoxycinnamic acid, whereas GC-MS analysis identified the presence of campesterol and ethyl isoallocholate that have been previously reported for anti-inflammatory activity. ALE showed significant inhibition of protein denaturation and proteinase activity and also controlled secretion of tumour necrosis factor-α, interleukin-1β and prostaglandins, as well as the generation of reactive oxygen species by activated macrophages. ALE also significantly decreased carrageenan-induced acute paw edema. The study, therefore, identified the components present in ALE that may be responsible for its anti-inflammatory activity and thus demonstrated its potential use against acute inflammatory diseases.

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Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties

Cited by 4 publications

References 28 publications

Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis

Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis

Transdermal iontophoresis of sodium nonivamide acetate evaluated by in vivo microdialysis and histologic study

Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus

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