Sodium‐potassium ATPase inhibition potentiates compound 48/80‐induced histamine secretion from mast cells

Amellal, M.; Binck, M.; Frossard, Nelly; Ilien, Brigitte; Landry, Yves

doi:10.1111/j.1476-5381.1984.tb10777.x

Cited by 34 publications

(16 citation statements)

References 27 publications

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“…Pearce (1982) suggested that calcium reservoirs deep within the cell membrane were the most likely location of the intracellular calcium stores involved in histamine secretion elicited in calcium-free media. We recently observed that the inhibition of mast cell sodium-potassium ATPase, in the presence of low calcium concentrations, potentiated the immunological histamine release ) and the release induced by compound 48/80 (Amellal et al, 1984;Binck et al, 1985). These potentiations were inhibited by EGTA and lanthanum, observations that are in agreement with the involvement of an increase of putative membranous calcium stores.…”

Section: Introductionsupporting

confidence: 71%

“…These potentiations were inhibited by EGTA and lanthanum, observations that are in agreement with the involvement of an increase of putative membranous calcium stores. However, the possibility that some minute influx of calcium, sufficient to induce exocytosis, might occur from the extracellular medium was not excluded (Amellal et al, 1984). Our concern in the present paper was to check this hypothesis using ionophore A23187 as a triggering agent of mast cell secretion, considered to bypass the plasma membranedependent steps of the regulation of exocytosis.…”

Section: Introductionmentioning

confidence: 99%

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Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187

Amellal

Bronner

Landry

1985

British J Pharmacology

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1 Histamine secretion was induced from rat peritoneal mast cells by calcium ionophore A23 187 in the presence of various extracellular calcium concentrations. Transmembrane sodium and potassium gradients were altered by cold pretreatment of mast cells or through the inhibition of sodiumpotassium ATPase by the use of ouabain or potassium-deprivation. 2 Such pretreatments led to a parallel shift to the left of the extracellular calcium concentrationhistamine secretion curve, i.e. to an apparent decrease of extracellular calcium requirement for the ionophore-induced histamine release. 3 These effects were fully reversed by warming mast cells, by washing out ouabain or by adding potassium. Metabolic inhibition of mast cells prevented the ionophore-induced secretion in all the experimental conditions described. Secretion observed in the absence of added calcium was inhibited by short term treatment of cells with 5 x 10-6 M EGTA or EDTA provided magnesium was absent from the assay medium. 4 Data show that ionophore A23187 was able to induce secretion in the presence of micromolar concentrations of extracellular calcium, when the efficiency of the ionophore was not decreased by extracellular m"gnesium and when transmembrane sodium and potassium gradients were altered.

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Section: Introductionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187

Amellal

Bronner

Landry

1985

British J Pharmacology

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“…The secretory responses of mast cells and other tissues are enhanced by digitalis glycosides (Vizi, 1978;Frossard et al, 1983;Powis, 1983;Amellal et al, 1984;1985 and references therein;Binck et al, 1985). Recently, we characterized the Na+-K+ pump mechanism in intact peritoneal mast cells of the rat and provided evidence for modulation of the pump activity by changes in the sodium permeability of the plasma membrane by extracellular calcium (Knudsen & Johansen, 1989a,b).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Na⁺ ‐K⁺ pump activity by divalent cations in intact peritoneal mast cells of the rat

Knudsen

Berthelsen

Johansen

1990

British J Pharmacology

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1The inhibition by the divalent cations magnesium, barium and strontium and the trivalent ion lanthanum of the Na+-K+ pump in the plasma membrane of rat peritoneal mast cells was studied in pure mast cell populations by measurement of the ouabain-sensitive uptake of the radioactive potassium analogue, 86rubidium (86Rb+). 2 Exposure of the cells to magnesium induced a time-and concentration-dependent decrease in the ouabain-sensitive K+(86Rb+)-uptake of the cells without influencing the ouabain-resistant uptake. The time-dependent decrease was apparent after incubation of the cells for 10min or more, but no decrease was observed after 2 min incubation when the cells are supposed to be loaded with sodium due to the cell isolation procedure.3 Barium and strontium caused concentration-dependent decreases in the ouabain-sensitive K+- (86Rb+) -uptake of the cells but the ouabain-resistant uptake was not changed. Half maximum decrease in the ouabain-sensitive K+(86Rb+)-uptake was observed with 1.8mM magnesium, 1.2mm barium and 0.7mM strontium.4 The trivalent ion lanthanum blocked almost completely the ouabain-sensitive K+(86Rb+)-uptake at a concentration of 1 gM as does 1 mm calcium. Combining either of these ions with magnesium had no further inhibitory effect on the ouabain-sensitive uptake. 5 In conclusion, in addition to the previously suggested modulation by calcium of the activity of the Na+-K+ pump, evidence is provided in this investigation that the modulation may be a more general effect of divalent and polyvalent cations present in the extracellular space through their influence on the sodium permeability of the plasma membrane.

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“…The Na+/K'-pump in the plasma membrane of mast cells [5] is inhibited by ouabain, and this allows the accumulation of sodium inside the cells. The enhancement by ouabain of histamine release develops gradually over 0.4-l h [2,3], and it is likely to be related to the accumulation of sodium, which may induce changes in a pool of calcium bound to the plasma membrane [4]. Erjavec and Ferjan [6] reported that hydrophilic digitalis glycosides enhance histamine release from rat mast cells induced by compound 48/80, while more lipophilic glycosides inhibit histamine release.…”

Section: Introductionmentioning

confidence: 99%

Effect of ouabain, digoxin and digitoxigenin on potassium uptake and histamine release from rat peritoneal mast cells

Knudsen¹,

Ferjan²,

Johansen³

1993

FEBS Letters

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Rat peritoneal mast cells were used to study the effects of digitalis glycosides on potassium uptake and histamine release induced by compound 48/80, substance P and egg-albumin (immunological release). In the absence of calcium all glycosides inhibited potassium uptake. Ouabain and digoxin enhanced the histamine release while digitoxigenin either had no effect or was slightly inhibitory. In the presence of calcium, the glycosides only affected potassium uptake and histamine release slightly. In the presence of lithium or lanthanum the enhancement of the histamine release was counteracted. Hydrophilic digitalis glycosides seem to enhance histamine release secondary to an increase in intracellular sodium. Lipophilic glycosides have no effect on the release.

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Sodium‐potassium ATPase inhibition potentiates compound 48/80‐induced histamine secretion from mast cells

Abstract: 1The effect of ouabain on the histamine secretion induced by compound 48/80 has been studied using rat peritoneal mast cells.

Cited by 34 publications

References 27 publications

Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187

Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187

Inhibition of Na⁺ ‐K⁺ pump activity by divalent cations in intact peritoneal mast cells of the rat

Effect of ouabain, digoxin and digitoxigenin on potassium uptake and histamine release from rat peritoneal mast cells

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Sodium‐potassium ATPase inhibition potentiates compound 48/80‐induced histamine secretion from mast cells

Abstract: 1The effect of ouabain on the histamine secretion induced by compound 48/80 has been studied using rat peritoneal mast cells.

Cited by 34 publications

References 27 publications

Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187

Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187

Inhibition of Na+ ‐K+ pump activity by divalent cations in intact peritoneal mast cells of the rat

Effect of ouabain, digoxin and digitoxigenin on potassium uptake and histamine release from rat peritoneal mast cells

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Inhibition of Na⁺ ‐K⁺ pump activity by divalent cations in intact peritoneal mast cells of the rat