Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation

Choi, Hyun‐Chul; Jeon, Eun Jeong; Kim, Dong Young; Choi, Mi Jin; Yu, Hana; Kim, Jea Il; Cheon, Hyae Gyeong

doi:10.1016/j.ejphar.2022.175085

Cited by 3 publications

(1 citation statement)

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“…In a gnotobiotic model employing F. duncaniae A2-165 and E. coli , metabolomic analysis identified several metabolites—including salicylic acid, shikimic acid, and raffinose—that could play a role in the benefits attributed to the bacterium (Miquel et al 2015b ). Some studies have suggested that salicylic acid could help treat obesity, by inducing the browning of white adipocytes (Choi et al 2022 ), or could serve as a preventive treatment for CRC (Imai et al 2022 ). Furthermore, it is used as a coadjuvant in cancer treatments because it can boost the effects of antitumor immunotherapy (Sun et al 2022 ).…”

Section: Host- Faecalibacterium Cross-talkmentioning

confidence: 99%

Faecalibacterium: a bacterial genus with promising human health applications

Martín

Ríos-Covián

Huillet

et al. 2023

FEMS Microbiology Reviews

127

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In humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases in the abundance of specific bacterial groups. One example is the genus Faecalibacterium. Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders. In this review, we first thoroughly describe updates to the taxonomy of Faecalibacterium, which has transformed a single-species taxon to a multispecies taxon over the last decade. We then explore the links discovered between Faecalibacterium abundance and various diseases since the first IBD-focused studies were published. Next, we examine current available strategies for modulating Faecalibacterium levels in the gut. Finally, we summarize the mechanisms underlying the beneficial effects that have been attributed to this genus. Together, epidemiological and experimental data strongly support the use of Faecalibacterium as a next-generation probiotic (NGP) or live biotherapeutic product (LBP).

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Section: Host- Faecalibacterium Cross-talkmentioning

confidence: 99%

Faecalibacterium: a bacterial genus with promising human health applications

Martín

Ríos-Covián

Huillet

et al. 2023

FEMS Microbiology Reviews

127

View full text Add to dashboard Cite

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Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

Wang,

Sun,

Yang

et al. 2023

J Orthop Surg Res

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Background Eccentric muscle contraction can cause muscle damage, which reduces the efficiency of exercise. Previous evidence suggested that Sodium salicylate (SS) could improve the repair of aged muscle. This study intends to investigate whether SS can impact skeletal muscle damage caused by eccentric exercise. Methods Eccentric treadmill exercise was performed to induce muscle damage in mice. Plasma levels of muscle damage markers were estimated. RT-qPCR was employed for detecting mRNA levels of proinflammatory mediators in murine gastrocnemius muscle. Immunofluorescence staining of laminin/DAPI was utilized for quantifying centrally nucleated myofibers in the gastrocnemius muscle. Western blotting was implemented to examine protein levels of mitsugumin 53 (MG53), matrix metalloproteinase (MMP)-2/9, and NF-κB signaling-related markers. Results SS administration reduced muscle damage marker production in the plasma and decreased the levels of proinflammatory mediators, MG53 and MMP-2/9 in mice after exercise. SS alleviated the severity of muscle damage in the gastrocnemius of mice after eccentric exercise. SS blocked NF-κB signaling pathway in the gastrocnemius muscle. Conclusion SS administration ameliorates skeletal muscle damage caused by eccentric exercise in the mouse model.

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Brown Algae Ecklonia cava Extract Modulates Adipogenesis and Browning in 3T3-L1 Preadipocytes through HO-1/Nrf2 Signaling

Suryaningtyas,

Lee,

2024

Marine Drugs

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This study explores the anti-obesity effects of the ethyl acetate extract of Ecklonia cava (EC-ETAC) on 3T3-L1 preadipocytes, focusing on its impact on adipogenesis, lipolysis, and adipose browning via the HO-1/Nrf2 pathway. Western blot analysis revealed that EC-ETAC significantly inhibited adipogenic transcription factors (PPARγ, C/EBPα, SREBP-1) and lipogenesis-related proteins (FAS, LPL). Concurrently, EC-ETAC enhanced lipolytic markers (p-AMPK, p-HSL) and adipose browning-related proteins (UCP-1, PGC-1α), indicating its role in promoting lipolysis and adipose browning. The inhibition of HO-1 by zinc protoporphyrin (ZnPP) significantly reversed these effects, underscoring the critical role of HO-1 in mediating the anti-obesity properties of EC-ETAC. Additionally, fluorescence measurements and Oil Red O staining confirmed the reduction of lipid accumulation and oxidative stress upon EC-ETAC treatment. These findings suggest that EC-ETAC exerts its anti-obesity effects by modulating the HO-1/Nrf2 pathway, which is crucial for regulating adipogenesis, lipolysis, and adipose browning. This study highlights the potential of EC-ETAC as a natural therapeutic agent for obesity management and supports further research into its clinical applications. By targeting the HO-1/Nrf2 pathway, EC-ETAC could offer a novel approach to enhancing energy expenditure and reducing fat mass, thereby improving metabolic health.

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Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation

Cited by 3 publications

References 53 publications

Faecalibacterium: a bacterial genus with promising human health applications

Faecalibacterium: a bacterial genus with promising human health applications

Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

Brown Algae Ecklonia cava Extract Modulates Adipogenesis and Browning in 3T3-L1 Preadipocytes through HO-1/Nrf2 Signaling

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