Sodium selenite supplementation during pregnancy and lactation promotes anxiolysis and improves mnemonic performance in wistar rats' offspring

Laureano‐Melo, Roberto; Império, Güínever E.; Almeida, Claudio da Silva; Kluck, George Eduardo Gabriel; Seara, Fernando A.C.; Rocha, Fábio Fagundes da; Silveira, Anderson Luiz Bezerra da; Reis, L. C.; Ortiga-Carvalho, Tânia M.; Cortês, Wellington da Silva

doi:10.1016/j.pbb.2015.09.007

Cited by 11 publications

(17 citation statements)

References 68 publications

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“…In animal studies, selenium deficiency during gestation affected markers of neurological development in rat offspring ( Mitchell et al 1998 ), and maternal selenium supplementation was negatively associated with anxiety-like behavior in pups and positively associated with cognitive function in adulthood ( Laureano-Melo et al 2015 ). In a Chinese study (

), cord blood selenium concentrations were positively associated with children’s neonatal behavioral neurological assessments scores (reflexes, passive tone, active tone, behavior, and general assessment) at 3 d of age ( Yang et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children

Skröder

Kippler

Tofail

et al. 2017

Environ Health Perspect

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Background:In older adults, selenium status has been positively associated with cognitive function. We recently reported a positive association between maternal selenium status in pregnancy and children’s cognitive function at 1.5 y.Objective:We followed up the children to assess if prenatal and childhood selenium status was associated with cognitive abilities at 5 and 10 y.Methods:This longitudinal cohort study was nested in Maternal and Infant Nutrition Interventions in Matlab (MINIMat), a population-based, randomized supplementation trial in pregnancy in rural Bangladesh. Selenium in maternal blood [erythrocyte fraction (Ery-Se) at baseline] and in child hair and urine was measured using inductively coupled plasma mass spectrometry. Children’s cognition at 5 and 10 y was assessed using the Wechsler Preschool and Primary Scale of Intelligence™ and the Wechsler Intelligence Scale for Children®, respectively. In total, 1,408 children were included.Results:Multivariable-adjusted linear regression analyses showed that prenatal selenium status was positively associated with children’s cognitive function at 5 and 10 y. An increase in maternal Ery-Se from the fifth to the 95th percentile [median: 0.44μg/g hemoglobin (Hb)] was associated with an increase in full developmental score of 3.5 [95% confidence interval (CI): 0.1, 7.0], corresponding to 0.16 standard deviation (SD) at 5 y, and 8.1 (95% CI: 3.8, 13), corresponding to 0.24 SD at 10 y. In addition, urine and hair selenium concentrations at 5 and 10 y of age were positively associated with cognitive function at 10 y, although associations were inverse for concentrations ≥98th percentile. Some associations were slightly stronger for girls than for boys.Conclusions:Measures of prenatal and childhood (below the 98th percentile) selenium status were associated with higher cognitive function scores at 5 and 10 y of age. https://doi.org/10.1289/EHP1691

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Section: Introductionmentioning

confidence: 99%

Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children

Skröder

Kippler

Tofail

et al. 2017

Environ Health Perspect

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“…In childhood, the selenium-supplemented offspring had a decrease in anxiety-like behavior; in adulthood, the locomotor activity and rearing episodes increased in selenium-treated pups. These findings demonstrated that maternal supplementation by sodium selenite induced psychobiological alterations during childhood and adulthood, probably caused by neurochemical changes generated by TH during the critical period of the central nervous system ontogeny [66].…”

Section: Seleniummentioning

confidence: 71%

“…Laureano-Melo and colleagues [66] evaluated potential behavioral alterations in offspring of female rats supplemented with sodium selenite during pregnancy and lactation. Selenium supplementation raised T3 and T4 serum levels, decreased tryptophan hydroxylase 2 expression and cholinesterase activity, and increased tyrosine hydroxylase expression in the hippocampus.…”

Section: Seleniummentioning

confidence: 99%

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

et al. 2020

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Nutraceuticals are defined as a food, or parts of a food, that provide medical or health benefits, including the prevention of different pathological conditions, and thyroid diseases, or the treatment of them. Nutraceuticals have a place in complementary medicines, being positioned in an area among food, food supplements, and pharmaceuticals. The market of certain nutraceuticals such as thyroid supplements has been growing in the last years. In addition, iodine is a fundamental micronutrient for thyroid function, but also other dietary components can have a key role in clinical thyroidology. Here, we have summarized the in vitro, and in vivo animal studies present in literature, focusing on the commonest nutraceuticals generally encountered in the clinical practice (such as carnitine, flavonoids, melatonin, omega-3, resveratrol, selenium, vitamins, zinc, and inositol), highlighting conflicting results. These experimental studies are expected to improve clinicians’ knowledge about the main supplements being used, in order to clarify the potential risks or side effects and support patients in their use.

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“…The control was treated with 0.9% saline, while the treated group received sodium selenite at a dose of 1 mg/kg. This dose was chosen in accordance with the data contained in the literature . The gavage administration was used for both groups to regulate the solutions ingested by the animals.…”

Section: Methodsmentioning

confidence: 99%

Selenium supplementation during pregnancy and lactation promotes metabolic changes in Wistar rats' offspring

Laureano‐Melo

Império

Kluck³

et al. 2020

Clin Exp Pharma Physio

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Epidemiological and animal studies have demonstrated a strong association between selenium (Se) supplementation and metabolic disorders, we aimed to evaluate whether maternal Se supplementation was able to change metabolic parameters in rats' offspring. Moreover, as Se is a deiodinase (DIO) cofactor, we decided to investigate how thyroid hormones (THs) would be involved in such metabolic changes.Thereby, two groups (n = 6, ~250 g) of female Wistar rats underwent isotonic saline or sodium selenite (1 mg/kg, p.o.) treatments. Although there were no significant differences in body weight between groups, the Se treatment during pregnancy and lactation increased milk intake and the visceral white adipose tissue (WAT) in offspring.The rats whose mothers were treated with Se also presented an improvement in the glucose tolerance test and in the glucose-stimulated insulin secretion. Regarding the lipid metabolism, the Se group had a reduction of triglycerides in the liver and in WAT.These metabolic changes were accompanied by an increase in serum triiodothyronine (T 3 ) and in DIO 2 expression in brown adipose tissue (BAT). We further demonstrate an increased expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) and nuclear respiratory factor-1 (NRF-1) mRNA in the liver. In adulthood offspring, Se supplementation programs thyroid function, glucose homeostasis, and feeding behaviour. Taken together, there is no indication that Se programming causes insulin resistance. Moreover, we conjecture that these metabolic responses are induced by increased thyroxine (T 4 ) to T 3 conversion by DIO2 in BAT and mediated by altered transcription factors expression associated with oxidative metabolism control in the liver. K E Y W O R D Sdeiodinase type II, metabolism, offspring, selenium supplementation, thyroid hormone | 1273 LAUREANO-MELO Et AL.

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Sodium selenite supplementation during pregnancy and lactation promotes anxiolysis and improves mnemonic performance in wistar rats' offspring

Cited by 11 publications

References 68 publications

Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children

Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

Selenium supplementation during pregnancy and lactation promotes metabolic changes in Wistar rats' offspring

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