Sodium Sulfide-Promoted Reaction of 2-Aminobenzamide and Benzyl Alcohols With Elemental Sulfur: A Novel Approach With 2-Aryl-Quinazolin-4(3h)

Abstract

Six derivatives containing benzoxazole were synthesized from phydroxybenzaldehyde via four step-route in high yields. The benzoxazole cyclization step was promoted with microwave irradiation for 10 to 30 min. Free oaminophenol derivative A3 reacted with aldehydes to form benzoxazole A4a-f, but A3.HCl couldn’t due to the presence of iron (II). Their structures were elucidated with spectroscopic methods: IR, 1D, 2D NMR, and MS.