Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants

Abstract

Extremely preterm (EPT) infants frequently experience intraventricular haemorrhage (IVH) mainly occurring within the first 72 h after birth. 1,2 The incidence of IVH is inversely related to gestational age (GA) and birth weight (BW), and very immature preterm infants are more likely to experience the higher grades of IVH occurring earlier after birth. [2][3][4] While mild IVH (grades 1 and 2) has been shown to increase the risk of neurodevelopmental impairment to a lesser extent, severe IVH (grade 3 or peri-ventricular haemorrhagic infarction [PVHI]) is a major risk factor for subsequent neurodevelopmental disability. 5 Besides immaturity, several risk factors have been

Actual electrolyte intake during the first week of life and morbidity in very‐low‐birthweight infants

“…Sodium restriction was associated with a decreased incidence of hypernatraemia and bronchopulmonary dysplasia, and the authors concluded that sodium intake during the first 3–5 days of life should be restricted 28 . In a recent retrospective case–control study of 140 extremely preterm (GA < 27 week) infants by Späth et al., 31 a higher early sodium supply until postnatal day 2 was associated with an increased risk of severe intraventricular haemorrhage. A similar association was found in our data of VLBW infants: a higher sodium intake during the first two days of life was associated with an increased risk of IVH even in the absence of hypernatraemia.…”