Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro

Liu, Yang; Zou, Xiaojing; Gao, Xiang; Chen, Hao; Luo, Jin; Wang, Zhaohua; Liang, Qiansheng; Gao, Yang

doi:10.3858/emm.2009.41.7.056

Cited by 47 publications

(35 citation statements)

References 42 publications

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“…The herbal compounds such as sodium tanshinone IIA [34] and resveratrol [29] exhibit beneficial effects on injured heart. Previous studies suggested that Gen protects against myocardial ischemia/reperfusion injury [22].…”

Section: Discussionmentioning

confidence: 99%

Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Fan¹,

Wang²,

Zhang³

et al. 2013

Cell Physiol Biochem

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Background/Aims: Arsenic trioxide (As₂O₃) is a highly effective agent for treatment of acute promyelocytic leukemia (APL). However, consecutively administered As₂O₃ induces serious adverse cardiac effects, including long QT syndrome (LQTs) and even sudden cardiac death. Previous studies have shown that genistein (Gen) exerts anti-oxidant, anti-inflammatory, and anti-apoptotic effects. The present study aimed to explore the potential protective effects of Gen on As₂O₃-induced adverse cardiac effects, and to elucidate the underlying molecular mechanisms. Methods: A rat model of As₂O₃-induced QT prolongation was generated by intravenous injection with As₂O₃. Surface electrocardiogram (ECG) and hemodynamics were employed to assess the LQTs and cardiac function. Intracellular calcium concentration ([Ca²⁺]_i) and mitochondrial membrane potential (Δψm) were measured by confocal microscopy, and cardiomyocytes apoptosis were assessed by TUNEL assay. Western blot was applied to determine protein levels. Results: We found for the first time that treatment with Gen significantly reversed LQTs and dose-dependently improved As₂O₃-induced impairment of cardiac function. As₂O₃ elevated [Ca²⁺]_i and Gen mitigated this effect. Meanwhile, Gen significantly reversed As₂O₃-mediated cardiomyocytes apoptosis. Furthermore, Gen dose-dependently inhibited the phosphorylated JNK and p38-MAPK (pp38-MAPK), and blocked Δψm collapse, and further decreased cleaved caspase-3. Conclusion: Gen protects against the adverse cardiac effects of As₂O₃ partly by mitigating cardiomyocytes apoptosis induced by As₂O₃ through attenuating intracellular calcium overload and downregulating protein expression of p-JNK and pp38-MAPK to ameliorate the damage of Δψm leading to suppression of caspase-3 activation. Gen might be used as an adjunction therapy in APL patients receiving As₂O₃ treatment to avoid, at least to minimize, the adverse cardiac effects of As₂O₃.

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Section: Discussionmentioning

confidence: 99%

Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Fan¹,

Wang²,

Zhang³

et al. 2013

Cell Physiol Biochem

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“…Tanshinone VI protects the myocardium against I/R injury and attenuates the progression of myocardial remodeling in vitro [119]. Tan IIA attenuates the expression of angiotensin II-induced collagen type I, ROS formation, and the proliferation of cardiac fibroblasts [120, 121]. Recent research also demonstrates that Tan IIA inhibits extracellular matrix remodeling induced by angiotensin II in human cardiac fibroblasts through inhibition of Smad signaling and MMP-9 expression via nuclear localization of NF- κ B [122].…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress and Salvia miltiorrhiza in Aging‐Associated Cardiovascular Diseases

Chang

et al. 2016

Oxidative Medicine and Cellular Longevity

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Aging-associated cardiovascular diseases (CVDs) have some risk factors that are closely related to oxidative stress. Salvia miltiorrhiza (SM) has been used commonly to treat CVDs for hundreds of years in the Chinese community. We aimed to explore the effects of SM on oxidative stress in aging-associated CVDs. Through literature searches using Medicine, PubMed, EMBASE, Cochrane library, CINAHL, and Scopus databases, we found that SM not only possesses antioxidant, antiapoptotic, and anti-inflammatory effects but also exerts angiogenic and cardioprotective activities. SM may reduce the production of reactive oxygen species by inhibiting oxidases, reducing the production of superoxide, inhibiting the oxidative modification of low-density lipoproteins, and ameliorating mitochondrial oxidative stress. SM also increases the activities of catalase, manganese superoxide dismutase, glutathione peroxidase, and coupled endothelial nitric oxide synthase. In addition, SM reduces the impact of ischemia/reperfusion injury, prevents cardiac fibrosis after myocardial infarction, preserves cardiac function in coronary disease, maintains the integrity of the blood-brain barrier, and promotes self-renewal and proliferation of neural stem/progenitor cells in stroke. However, future clinical well-designed and randomized control trials will be necessary to confirm the efficacy of SM in aging-associated CVDs.

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“…Tan IIA can inhibit these reactions, which have been mentioned in the above experiments [8, 28–32]. To test the hypothesis that Tan IIA can alter the expression and/or activity of specific antioxidant enzymes to prevent cells from oxidant damage, at least three experiments [38, 43, 44] were conducted and demonstrated that the cell protective effect of Tan IIA was mediated primarily by induction of glutathione peroxidase (GPx) gene expression and activity, as well as other antioxidant enzyme activities in the heart.…”

Section: Cardiovascular Pharmacologymentioning

confidence: 99%

Tanshinone IIA: A Promising Natural Cardioprotective Agent

Shang

Huang

2012

Evidence-Based Complementary and Alternative Medicine

109

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Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not easy to be absorbed through intestinal pathway. To raise the bioavailability of the herb, sodium tanshinone IIA sulfonate (STS) was developed. This paper discussed the pharmacology of Tan IIA, STS, and their potential cardioprotective effects.

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Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro

Cited by 47 publications

References 42 publications

Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Oxidative Stress and Salvia miltiorrhiza in Aging‐Associated Cardiovascular Diseases

Tanshinone IIA: A Promising Natural Cardioprotective Agent

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