Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts

Zhou, Dan; Yang, Wenke; Zhang, Yifan; Xie, Jiaheng; Ma, Li; Yang, Heiko; Li, Yi; Xie, Ping

doi:10.1016/s1875-5364(20)30051-0

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…The late effects of radiotherapy are due to IR and IR-induced production of chronic free radicals from water molecules in the surrounding environment ( 47 ). STS significantly inhibits the increase of ROS and MDA content in H9C2 cells and cardiac fibroblasts (CFS) under X-ray radiation and increased the level of SOD ( 48 , 49 ).…”

Section: Molecular Mechanisms Of Chemoradiotherapy-related Cardiotoxi...mentioning

confidence: 99%

“…Additionally, IR-induced DNA damage initiates apoptosis through a p53-dependent mechanism that activates downstream caspases ( 104 ). STS can disrupt the p53 pathway in CFs by decreasing the phosphorylation levels of p38, caspases 3 expression, and increasing the levels of Bax and phosphorylated ERK1/2 ( 49 ). DBD can reduce Fas ligand (Fasl) and TNF-α expression, block apoptotic signaling pathways, and attenuate radiological myocardial injury in CMs ( 105 ) ( Figure 4 ).…”

Section: Molecular Mechanisms Of Chemoradiotherapy-related Cardiotoxi...mentioning

confidence: 99%

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Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Wen

et al. 2022

Front. Cardiovasc. Med.

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Cardiotoxicity is a serious complication of cancer therapy. It is the second leading cause of morbidity and mortality in cancer survivors and is associated with a variety of factors, including oxidative stress, inflammation, apoptosis, autophagy, endoplasmic reticulum stress, and abnormal myocardial energy metabolism. A number of studies have shown that traditional Chinese medicine (TCM) can mitigate chemoradiotherapy-associated cardiotoxicity via these pathways. Therefore, this study reviews the effects and molecular mechanisms of TCM on chemoradiotherapy-related cardiotoxicity. In this study, we searched PubMed for basic studies on the anti-cardiotoxicity of TCM in the past 5 years and summarized their results. Angelica Sinensis, Astragalus membranaceus Bunge, Danshinone IIA sulfonate sodium (STS), Astragaloside (AS), Resveratrol, Ginsenoside, Quercetin, Danggui Buxue Decoction (DBD), Shengxian decoction (SXT), Compound Danshen Dripping Pill (CDDP), Qishen Huanwu Capsule (QSHWC), Angelica Sinensis and Astragalus membranaceus Bunge Ultrafiltration Extract (AS-AM),Shenmai injection (SMI), Xinmailong (XML), and nearly 60 other herbs, herbal monomers, herbal soups and herbal compound preparations were found to be effective as complementary or alternative treatments. These preparations reduced chemoradiotherapy-induced cardiotoxicity through various pathways such as anti-oxidative stress, anti-inflammation, alleviating endoplasmic reticulum stress, regulation of apoptosis and autophagy, and improvement of myocardial energy metabolism. However, few clinical trials have been conducted on these therapies, and these trials can provide stronger evidence-based support for TCM.

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Section: Molecular Mechanisms Of Chemoradiotherapy-related Cardiotoxi...mentioning

confidence: 99%

Section: Molecular Mechanisms Of Chemoradiotherapy-related Cardiotoxi...mentioning

confidence: 99%

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Wen

et al. 2022

Front. Cardiovasc. Med.

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show abstract

Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review

Dabbaghi,

Soleimani Roudi,

Safaei

et al. 2024

Cardiovasc Toxicol

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Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway

Xuan

Cai

Kang

et al. 2023

Microbes and Infection

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Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts

Cited by 5 publications

References 46 publications

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review

Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway

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