Sodium thiosulfate attenuates angiotensin II-induced hypertension, proteinuria and renal damage11These authors contributed equally to this manuscript.

Snijder, Pauline M.; Frenay, Anne‐Roos S.; Koning, Anne M.; Bachtler, Matthias; Pasch, Andreas; Kwakernaak, Arjan J.; Berg, Else van den; Bos, Eelke M.; Hillebrands, Jan-Luuk; Navis, Gerjan; Leuvenink, Henri G. D.; Goor, Harry van

doi:10.1016/j.niox.2014.10.002

Cited by 80 publications

(52 citation statements)

References 64 publications

(86 reference statements)

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“…The finding that PAG consistently abolished H 2 S production suggests that CBS and MST may also have been affected. Both the blood pressure reduction and the amelioration of renal injury by PAG treatment in AngII-infused rats are contradictory to our previous findings showing that exogenous H 2 S resulted in improvement of blood pressure and less renal injury in this model [12].…”

Section: Discussioncontrasting

confidence: 99%

“…Besides amelioration of renal function by H 2 S donors in AngII infusion, tubular and glomerular damage and interstitial fibrosis were reduced [12]. However, in the present study inhibition of H 2 S resulted also in decreased glomerular and tubular damage.…”

Section: Discussioncontrasting

confidence: 60%

“…Hypertension-driven renal injury was induced by AngII infusion (435 ng/kg/min, Bachem, Weil am Rhein, Germany) for three weeks via a subcutaneous osmotic minipump (model 2004, Alzet, Cupertino, CA) which were implanted under isoflurane anesthesia with buprenorphine analgesia [12]. As a control for AngII infusion, saline-filled minipumps were implanted in a group of rats (n=5, VEH).…”

Section: Methodsmentioning

confidence: 99%

“…Increasing H 2 S availability by two different H 2 S donors decreased blood pressure and improved renal function and morphology in Angiotensin II (AngII)-infused rats [12]. Inhibiting H 2 S synthesis by administration of both PAG and aminooxyacetic acid (AOA), a CBS blocker, increased mean arterial pressure (MAP) and decreased renal blood flow without affecting glomerular filtration rate indicating post-glomerular vasoconstriction while treatment with only one of these enzyme blockers did not affect MAP and renal function in healthy rats [13].…”

Section: Introductionmentioning

confidence: 99%

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dl-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats

Oosterhuis

Frenay²,

Wesseling

et al. 2015

Nitric Oxide

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Hydrogen sulfide (H 2 S), carbon monoxide (CO) and nitric oxide (NO) share signaling and vasorelaxant properties and are involved in proliferation and apoptosis. Inhibiting NO production or availability induces hypertension and proteinuria, which is prevented by concomitant blockade of the H 2 S producing enzyme cystathionine γ-lyase (CSE) by D,L-propargylglycine (PAG). We hypothesized that blocking H 2 S production ameliorates Angiotensin II (AngII)-induced hypertension and renal injury in a rodent model.Effects of concomitant administration of PAG or saline were therefore studied in healthy (CON) and AngII hypertensive rats.In CON rats, PAG did not affect systolic blood pressure (SBP), but slightly increased proteinuria. In AngII rats PAG reduced SBP, proteinuria and plasma creatinine (180±12 vs. 211±19 mmHg; 66±35 vs. 346±92 mg/24h; 24±6 vs. 47±15 µmol/L, respectively; p<0.01). Unexpectedly, kidney to body weight ratio was increased in all groups by PAG (p<0.05). Renal injury induced by AngII was reduced by PAG (p<0.001).HO-1 gene expression was increased by PAG alone (p<0.05). PAG increased inner cortical tubular cell proliferation after 1 week and decreased outer cortical tubular nucleus number/field after 4 weeks. In vitro proximal tubular cell size increased after exposure to PAG. In summary, blocking H 2 S production with PAG reduced SBP and renal injury in AngII infused rats.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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dl-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats

Oosterhuis

Frenay²,

Wesseling

et al. 2015

Nitric Oxide

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“…The closest existing compound to H 2 S in clinical use is sodium thiosulfate. Sodium thiosulfate was studied in an angiotensin-induced hypertensive rat model and showed that it reduced hypertension, proteinuria, oxidative stress, and functional and structural renal parameters (41). In practice, however, sodium thiosulfate has been mainly used for the treatment of calciphylaxis and resulted in case reports of severe anion gap metabolic acidosis via an unknown mechanism (42,43).…”

Section: Hydrogen Sulfide Pathwaymentioning

confidence: 99%

Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines

Phipps

Prasanna

Brima

et al. 2016

CJASN

509

328

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Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a selflimited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after.

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Role of hydrogen sulfide in health and disease

Jin,

Yuan,

Liu

et al. 2024

MedComm

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In the past, hydrogen sulfide (H2S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H2S can act as an endogenous regulatory transmitter. In mammals, H2S‐catalyzing enzymes, such as cystathionine‐β‐synthase, cystathionine‐γ‐lyase, and 3‐mercaptopyruvate sulfurtransferase, are differentially expressed in a variety of tissues and affect a variety of biological functions, such as transcriptional and posttranslational modification of genes, activation of signaling pathways in the cell, and metabolic processes in tissues, by producing H2S. Various preclinical studies have shown that H2S affects physiological and pathological processes in the body. However, a detailed systematic summary of these roles in health and disease is lacking. Therefore, this review provides a thorough overview of the physiological roles of H2S in different systems and the diseases associated with disorders of H2S metabolism, such as ischemia–reperfusion injury, hypertension, neurodegenerative diseases, inflammatory bowel disease, and cancer. Meanwhile, this paper also introduces H2S donors and novel release modes, as well as the latest preclinical experimental results, aiming to provide researchers with new ideas to discover new diagnostic targets and therapeutic options.

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Sodium thiosulfate attenuates angiotensin II-induced hypertension, proteinuria and renal damage11These authors contributed equally to this manuscript.

Cited by 80 publications

References 64 publications

dl-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats

dl-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats

Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines

Role of hydrogen sulfide in health and disease

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