Sodium transport and bone mineral density in hypercalciuria  with thiazide treatment

Reusz, György; Dobos, M.; Vásárhelyi, Barna; Sartipy, Peter; Szabó, András; Horváth, Csaba; Szabó, Antal; Byrd, Dennis J.; Thole, Hubert; Tulassay, Tivadar

doi:10.1007/s004670050398

Cited by 36 publications

(27 citation statements)

References 22 publications

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“…Intact (1-84) PTH (iPTH) was determined by immunochemiluminometric two-site assay (CIBA-CORNING, Fernwald, Germany). The reference range of the assay is 9 -60 pg/mL (13).…”

Section: Patients With Esrdmentioning

confidence: 99%

Pulse Wave Velocity in End-Stage Renal Disease: Influence of Age and Body Dimensions

et al. 2008

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Arterial stiffness increases with age. This process is accelerated by end-stage renal disease (ESRD). Pulse wave velocity (PWV) increases with arterial stiffness. In this study, PWV of 133 healthy individuals (6 -23 y of age) and 11 patients on dialysis was measured to establish the normal values of PWV and to compare them with those in ESRD. Age-matched (A-C) and height-and weight-matched (H/W-C) control groups were used. Thereafter, PWV was indexed to height and the data were reevaluated. The role of the risk factors including serum calcium, phosphate, parathyroid hormone (PTH), and the time on dialysis was analyzed using a score system. PWV correlated with age, weight, height, blood pressure, and heart rate. ESRD patients were smaller than A-C and older than H/W-C. PWV of patients with ESRD did not differ from A-C; however, it was elevated in comparison to H/W-C. In both healthy and ESRD patients, the PWV/height ratio was independent of age. PWV/height was increased in ESRD. There was a correlation between PWV/height and the risk factor score. Controls matched for height and weight or PWV/height should be used in cases of growth failure. A number of risk factors responsible for increased arterial stiffness are present in ESRD. (Pediatr Res 63: 95-98, 2008)

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“…Intact (1-84) PTH (iPTH) was determined by immunochemiluminometric two-site assay (CIBA-CORNING, Fernwald, Germany). The reference range of the assay is 9 -60 pg/mL (13).…”

Section: Patients With Esrdmentioning

confidence: 99%

Pulse Wave Velocity in End-Stage Renal Disease: Influence of Age and Body Dimensions

et al. 2008

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“…In addition, these studies have been cross-sectional, with some performing bone densitometry using dual-emission X-ray absorptiometry (DXA) technology, while others did not. Consequently, the published results are controversial [15][16][17][18][19], partially explaining why many clinicians are reluctant to prescribe thiazides to children. Although there is large body of evidence demonstrating the ability of hydrochlorothiazide to restore normocalciuria, little is known on the impact of such therapy on BMD, at least in children.…”

Section: Introductionmentioning

confidence: 98%

Effect of thiazides on bone mineral density in children with idiopathic hypercalciuria

et al. 2011

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To determine the effect of thiazide treatment on bone mineral density (BMD) in children with idiopathic hypercalciuria (IH) and osteopenia, we reviewed the case notes of 22 children aged 11.7 ± 2.7 years diagnosed with IH and osteopenia who had received thiazides for 2.4 years. The data on this group were compared with those of 32 IH children with osteopenia aged 11.2 ± 2.7 years who had not received thiazide treatment. By the end of the follow-up period, the z-BMD had improved spontaneously in 23 of the 32 control children (72%) and in 12 of the 22 patients on thiazides (54%). Although treated patients had a higher body mass index (BMI) and a higher BMD following treatment, the differences became statistically negligible when these parameters were expressed as z-BMD or as bone mineral apparent density (BMAD). In contrast, within the control group, there were significant differences in BMAD and z-BMD at the end of the follow-up. Patients who had an improved z-BMD at the end of the treatment also showed an increase in their BMI. Based on these results, we conclude that thiazide treatment does not improve the z-BMD in children with IH. More than half of the children suffering from IH enrolled in our study showed a spontaneous improvement in their z-BMD, which was more evident when the initial BMAD was not low and when their BMI increased during the follow-up period.

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“…The main reason is the fact of being considered as a supplement, but studies with more detailed information on its effects in the pediatric population are lacking [102] . Studies by Reusz et al [103] and Schwaderer et al [104] demonstrated the beneficial effects of thiazides and/or potassium citrate on bone mineral density in children with IH. According to Srivastava et al [102] , drug therapy should be reserved for children with symptomatic hypercalcuria and/or rare monogenic disorders.…”

Section: Idiopathic Calcium Stonesmentioning

confidence: 99%

Pediatric primary urolithiasis: Symptoms, medical management and prevention strategies

Penido

Tavares

2015

WJN

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In the past few decades pediatric urolithiasis has become more frequent. The reason for this increase is not completely clear but has been attributed to changes in climate, nutritional habits and possibly other environmental factors. Although less frequent than adult stone disease, urolithiasis in the pediatric age group is also related to significant morbidity, particularly since stones tend to recur, and, thus, should not be underestimated. Most children with idiopathic stone disease have an underlying metabolic abnormality substantiating the importance of metabolic evaluation already following initial diagnosis of urolithiasis. Identification of the metabolic abnormality allows for more specific prescription of non pharmacological and pharmacological interventions aimed at preventing recurrent stone formation. A better understanding of the causes of kidney stone disease will provide better strategies for stone prevention in children.

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Sodium transport and bone mineral density in hypercalciuria with thiazide treatment

Cited by 36 publications

References 22 publications

Pulse Wave Velocity in End-Stage Renal Disease: Influence of Age and Body Dimensions

Pulse Wave Velocity in End-Stage Renal Disease: Influence of Age and Body Dimensions

Effect of thiazides on bone mineral density in children with idiopathic hypercalciuria

Pediatric primary urolithiasis: Symptoms, medical management and prevention strategies

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