Sodium tungstate induced neurological alterations in rat brain regions and their response to antioxidants

Sachdeva, Sherry; Pant, S. C.; Kushwaha, Pramod; Bhargava, Rakesh; Flora, Swaran J.S.

doi:10.1016/j.fct.2015.05.003

Cited by 31 publications

(15 citation statements)

References 41 publications

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“…This compound is stable, showing chemical resistance in several oxidation states (0, +2, +3, +4, +5, and +6) . In the literature, the main sources of tungstate release into the environment have been reported to be weathering of rocks and soils, sewage sludge, fertilizers, and municipal solid waste ash …”

Section: Introductionmentioning

confidence: 86%

“…Tungstate (W) is a naturally occurring element found in various sources, including food, water, and soil . The broad applications of tungstate in bulb filaments, X‐ray tubes, and electrodes, along with its industrial and military applications, have caused growing concerns, considering its toxic effects on the environment and human body . This compound is stable, showing chemical resistance in several oxidation states (0, +2, +3, +4, +5, and +6) .…”

Section: Introductionmentioning

confidence: 99%

“…Another study showed that tungstate caused a significant increase in oxidative stress biomarkers and promoted neurological changes in the cerebral cortex of the brain. Also, N ‐acetylcysteine (NAC) could effectively restore oxidative stress and brain alterations . Previous studies show that oxidative stress is one of the major mechanisms of tungstate‐induced toxicity in the liver, kidneys, and brain, leading to continuous ROS formation and changes in neurotransmitter levels in the brain…”

Section: Introductionmentioning

confidence: 99%

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High doses of sodium tungstate can promote mitochondrial dysfunction and oxidative stress in isolated mitochondria

Cheraghi

Hajiabedi

Niaghi

et al. 2018

J Biochem & Molecular Tox

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Tungstate (W) is recognized as an agent of environmental pollution and a substitute to depleted uranium. According to some preliminary studies, tungstate toxicity is related to the formation of reactive oxygen species (ROS) under abnormal pathological conditions. The kidneys and liver are the main tungstate accumulation sites and important targets of tungstate toxicity. Since the mitochondrion is the main ROS production site, we evaluated the mechanistic toxicity of tungstate in isolated mitochondria for the first time, following a two‐step ultracentrifugation method. Our findings demonstrated that tungstate‐induced mitochondrial dysfunction is related to the increased formation of ROS, lipid peroxidation, and potential membrane collapse, correlated with the amelioration of adenosine triphosphate and glutathione contents. The present study indicated that mitochondrial dysfunction was associated with disruptive effects on the mitochondrial respiratory chain and opening of mitochondrial permeability transition (MPT) pores, which is correlated with cytochrome c release. Our findings suggest that high concentrations of tungstate (2 mM)‐favored MPT pore opening in the inner membranes of liver and kidney mitochondria of rats. Besides, the results indicated higher tungstate susceptibility in the kidneys, compared with the liver.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High doses of sodium tungstate can promote mitochondrial dysfunction and oxidative stress in isolated mitochondria

Cheraghi

Hajiabedi

Niaghi

et al. 2018

J Biochem & Molecular Tox

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show abstract

“…For example, oral quercetin (0.5–50 mg/kg) was shown to protect rodents from oxidative stress and neurotoxicity induced by various neurotoxic insults [ 21 , 25 ]. Among metals, quercetin has been shown to provide protection against the neurotoxicity of lead, methylmercury, and tungsten [ 38 , 40 , 43 ]. The neurotoxicity of polychlorinated biphenyls, of the insecticide endosulfan, and of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has also been shown to be reduced by quercetin in vivo [ 39 , 41 , 42 ].…”

Section: Neuroprotective Effects Of Quercetin: Human and Animal Stmentioning

confidence: 99%

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Costa

Garrick

Roqué

et al. 2016

Oxidative Medicine and Cellular Longevity

405

273

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Increasing interest has recently focused on determining whether several natural compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in the developing, adult, and aging nervous system. Quercetin, a polyphenol widely present in nature, has received the most attention in this regard. Several studies in vitro, in experimental animals and in humans, have provided supportive evidence for neuroprotective effects of quercetin, either against neurotoxic chemicals or in various models of neuronal injury and neurodegenerative diseases. The exact mechanisms of such protective effects remain elusive, though many hypotheses have been formulated. In addition to a possible direct antioxidant effect, quercetin may also act by stimulating cellular defenses against oxidative stress. Two such pathways include the induction of Nrf2-ARE and induction of the antioxidant/anti-inflammatory enzyme paraoxonase 2 (PON2). In addition, quercetin has been shown to activate sirtuins (SIRT1), to induce autophagy, and to act as a phytoestrogen, all mechanisms by which quercetin may provide its neuroprotection.

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“…99 However, soluble sodium tungstate administered chronically to rats has been shown to induce oxidative stress in the brain and neurobehavioral changes. 100, 101 Heavy metal tungsten alloy particles are used as a less toxic alternative for depleted uranium for military applications. However, these particles have been shown to induce acute oxidative stress and lung toxicity following intratracheal instillation in rats.…”

Section: Literature Review On Biological Response and Riskmentioning

confidence: 99%

Biological and environmental interactions of emerging two-dimensional nanomaterials

Wang¹,

Zhu²,

Qiu³

et al. 2016

Chem. Soc. Rev.

239

210

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Two-dimensional materials have become a major focus in materials chemistry research worldwide with substantial efforts centered on synthesis, property characterization, and technological application. These high-aspect ratio sheet-like solids come in a wide array of chemical compositions, crystal phases, and physical forms, and are anticipated to enable a host of future technologies in areas that include electronics, sensors, coatings, barriers, energy storage and conversion, and biomedicine. A parallel effort has begun to understand the biological and environmental interactions of synthetic nanosheets, both to enable the biomedical developments and to ensure human health and safety for all application fields. This review covers the most recent literature on the biological responses to 2D materials and also draws from older literature on natural lamellar minerals to provide additional insight into the essential chemical behaviors. The article proposes a framework for more systematic investigation of biological behavior in the future, rooted in fundamental materials chemistry and physics. That framework considers three fundamental interaction modes: (i) chemical interactions and phase transformations, (ii) electronic and surface redox interactions, and (iii) physical and mechanical interactions that are unique to near-atomically-thin, high-aspect-ratio solids. Two-dimensional materials are shown to exhibit a wide range of behaviors, which reflect the diversity in their chemical compositions, and many are expected to undergo reactive dissolution processes that will be key to understanding their behaviors and interpreting biological response data. The review concludes with a series of recommendations for high-priority research subtopics at the “bio-nanosheet” interface that we hope will enable safe and successful development of technologies related to two-dimensional nanomaterials.

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Sodium tungstate induced neurological alterations in rat brain regions and their response to antioxidants

Cited by 31 publications

References 41 publications

High doses of sodium tungstate can promote mitochondrial dysfunction and oxidative stress in isolated mitochondria

High doses of sodium tungstate can promote mitochondrial dysfunction and oxidative stress in isolated mitochondria

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Biological and environmental interactions of emerging two-dimensional nanomaterials

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