Sodium Valproate, an Anticonvulsant Drug, Stimulates Human Immunodeficiency Virus Type 1 Replication Independently of Glutathione Levels

Moog, Christiane; Kuntz-Simon, Gaëlle; Caussin‐Schwemling, Catherine; Obert, G.

doi:10.1099/0022-1317-77-9-1993

Cited by 64 publications

(30 citation statements)

References 42 publications

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“…Already in 1996, Moog and coworkers reported that valproic acid (VPA), a weak HDACi, markedly increased the HIV replication in various infected cell lines and primary cell cultures. 69 Later, Chen et al 70 were able to prove a dramatic reactivation of gene expression after treatment with trapoxin, a strong HDACi, in a transfected cell line carrying a silent, integrated copy of a virally transduced gene. By forcing the viral expression, a new potential therapeutic approach emerged to decrease the pool of latent retrovirus reservoirs.…”

Section: Potential Therapeutic Treatment For Blv-infected Cowsmentioning

confidence: 99%

Bovine leukemia virus: current perspectives

Juliarena¹,

Barrios²,

Lützelschwab³

et al. 2017

VAAT

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Enzootic bovine leukosis, caused by bovine leukemia virus (BLV), is the most common neoplasm of dairy cattle. Although beef and dairy cattle are susceptible to BLV infection and BLV-associated lymphosarcoma, the disease is more commonly detected in dairy herds, mostly because of the management practices in dairy farms. The pathogenicity of BLV in its natural host, the bovine, depends mainly on the resistance/susceptibility genetics of the animal. The majority of infected cattle are asymptomatic, promoting the extremely high dissemination rate of BLV in many bovine populations. The important productive losses caused by the BLV, added to the health risk of maintaining populations with a high prevalence of infection with a retrovirus, generates the need to implement control measures. Different strategies to control the virus have been attempted. The most effective approach is to identify and cull the totality of infected cattle in the herd. However, this approach is not suitable for herds with high prevalence of infection. At present, no treatment or vaccine has proven effective for the control of BLV. Thus far, the genetic selection of resistant animals emerges as a natural strategy for the containment of the BLV dissemination. In natural conditions, most of the infected, resistant cattle can control the infection, and therefore do not pass the virus to other animals, gradually decreasing the prevalence of the herd.

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Section: Potential Therapeutic Treatment For Blv-infected Cowsmentioning

confidence: 99%

Bovine leukemia virus: current perspectives

Juliarena¹,

Barrios²,

Lützelschwab³

et al. 2017

VAAT

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“…33 Early reports raised some concerns that it may increase viral loads by stimulating replication. 34 More recently it was suggested that this effect, in combination with ART, may lead to the possibility of cure by depleting latent viral stores, 35 but unfortunately this has not been substantiated. 36 Whether sodium valproate may lead to cognitive decline in HIV-positive individuals or not is not entirely resolved, however, with some studies showing no decline 37,38 but one study suggesting problems with longer-term use at higher doses.…”

Section: Bipolar Disorder and Maniamentioning

confidence: 99%

Psychotropic prescribing in HIV

Parker¹

2009

South. Afr. j. HIV med.

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“…Also, TSA was shown to synergise with TNF-a to cause NF-kB mediated re-expression of the HIV-LTR [183]. Valproic acid (VPA), also an HDAC inhibitor, has been shown to increase HIV gene expression and virus production in cultured latently infected cells [184][185]. VPA was shown in another study to induce the expression of HIV from resting CD4+ T-cells, isolated from patients receiving HAART treatment without fully activating the cells or enhancing new rounds of HIV infection [186].…”

Section: Induction Of Viral Expression Without Host Cell Activationmentioning

confidence: 99%