Sodium Valproate and Valproic Acid

Chang, Zui L.

doi:10.1016/s0099-5428(08)60128-8

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…Furthermore, VPA can be used as an anticonvulsant in management of the childhood refractory epilepsy, showing good response rates and acceptable toxicity. VPA is the most effective in primary generalized epilepsy, especially when used as the solo antiepileptic drug. − Also, it was recently ascertained to be a cancer inhibitor toward brain tumor and neuroendocrine tumors. − …”

Section: Introductionmentioning

confidence: 99%

Prediction of Solubility of Sodium Valproate in Supercritical Carbon Dioxide: Experimental Study and Thermodynamic Modeling

et al. 2020

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The key factor for designing of micro- and nanosized particles production processes is determination of a solid solute solubility. In the current investigation, for the first time, the solubility of sodium valproate in supercritical CO2 was investigated. Solubility investigations were conducted at different temperatures (308.15–338.15 K) and pressure values (12–27 MPa). Sodium valproate provided mole fraction solubility values of 0.05 × 10–5 to 3.71 × 10–5 within the experimental range studied. For the studied system, data correlation has been examined by equations of state (EoSs) including Soave–Redlich–Kwong (SRK), Peng–Robinson (PR), and Estevez models as well as SAFT-VR and four semi-empirical models (Kumar and Johnston, Méndez-Santiago and Teja, Jouyban et al., Sodeifian et al., Bartle et al., Chrastil’s models and Reddy and Garlapati models). Statistical criteria (AARD, R adj, and F-value) were used to appraise their precision. The analysis of variance (ANOVA) also indicated the superior performance of the PR, SRK, Estevez, and SAFT-VR EoSs. Furthermore, density-based models generally exhibited excellent agreement with the experimental data.

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Section: Introductionmentioning

confidence: 99%

Prediction of Solubility of Sodium Valproate in Supercritical Carbon Dioxide: Experimental Study and Thermodynamic Modeling

et al. 2020

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“…It is available in several salt forms, including valproate semi‐sodium and sodium valproate. Sodium valproate is reported to be chemically stable in acid and base, in the presence of light and under conditions of extreme temperature [12] . It is, however, expected to exhibit instability in the presence of moisture due to its hygroscopic and deliquescent nature.…”

Section: Introductionmentioning

confidence: 99%

Stability of sodium valproate tablets repackaged into dose administration aids

Llewelyn

Mangan

Glass

2010

Journal of Pharmacy and Pharmacology

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Objectives Since sodium valproate, a commonly used antiepileptic drug, has been reported to be unstable in the presence of moisture, our objective was to investigate the effect of repackaging into dose administration aids. Methods Sodium valproate 100 mg immediate-release tablets were repackaged and stored for 56 days at accelerated conditions (40°C/75% relative humidity), room temperature (25°C) and under refrigeration (2-8°C). Samples were analysed at 3, 7, 10, 14, 21, 35, 49 and 56 days to determine chemical stability using high-performance liquid chromatography, while physical testing included assessment of weight changes and dissolution behaviour. Key findings The results revealed that the sodium valproate content in the tablets remained within the acceptable range of 90-110% under all storage conditions for 56 days. Physical stability, however, was not maintained, with a total weight gain of 12.36% under accelerated conditions over the 56 days. Samples stored under all conditions showed variable dissolution compared to the controls, with the amount of sodium valproate in solution following 45 min of dissolution testing below 75% for half of all the intervals determined. Conclusions Repackaging sodium valproate tablets into dose administration aids results in unacceptable weight variation and changes in the dissolution profiles.

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“…Valproic acid, also known as 2-propyl pentanoic acid, is a branched and short-chain fatty acid chemically produced by different synthetic pathways [ 14 ], one of them as a product derivate from valeric acid [ 8 ] (Fig. 1 ).…”

Section: Valproate (Vpa)mentioning

confidence: 99%

Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder

Zarate-Lopez,

Torres-Chávez,

Gálvez-Contreras

et al. 2024

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Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased prevalence and incidence in recent decades. Its etiology remains largely unclear, but it seems to involve a strong genetic component and environmental factors that, in turn, induce epigenetic changes during embryonic and postnatal brain development. In recent decades, clinical studies have shown that inutero exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug, is an environmental factor associated with an increased risk of ASD. Subsequently, prenatal VPA exposure in rodents has been established as a reliable translational model to study the pathophysiology of ASD, which has helped demonstrate neurobiological changes in rodents, non-human primates, and brain organoids from human pluripotent stem cells. This evidence supports the notion that prenatal VPA exposure is a valid and current model to replicate an idiopathic ASD-like disorder in experimental animals. This review summarizes and describes the current features reported with this animal model of autism and the main neurobiological findings and correlates that help elucidate the pathophysiology of ASD. Finally, we discuss the general framework of the VPA model in comparison to other environmental and genetic ASD models.

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Sodium Valproate and Valproic Acid

Cited by 15 publications

References 13 publications

Prediction of Solubility of Sodium Valproate in Supercritical Carbon Dioxide: Experimental Study and Thermodynamic Modeling

Prediction of Solubility of Sodium Valproate in Supercritical Carbon Dioxide: Experimental Study and Thermodynamic Modeling

Stability of sodium valproate tablets repackaged into dose administration aids

Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder

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