2015
DOI: 10.1002/hep.27581
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Sofosbuvir modulates the intimate relationship between hepatitis C virus and lipids

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Cited by 8 publications
(6 citation statements)
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“…Interestingly, lipid levels changed to a more atherogenic profile with increase in TC, cLDL, apolipoprotein B, and lipoprotein-A, whereas endothelial dysfunction and subclinical atherosclerosis improved. This observation could be explained, at least, partly by: (i) lipid profiles that remain within the normal range; (ii) HCV ability to hijack lipid metabolism has given a “false” protective atherogenic profile that is restored after viral clearance; and (iii) the impact that HCV has on other CV risk factors such as insulin resistance (i.e., the improvement in the HOMA index) ( 25 29 ).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, lipid levels changed to a more atherogenic profile with increase in TC, cLDL, apolipoprotein B, and lipoprotein-A, whereas endothelial dysfunction and subclinical atherosclerosis improved. This observation could be explained, at least, partly by: (i) lipid profiles that remain within the normal range; (ii) HCV ability to hijack lipid metabolism has given a “false” protective atherogenic profile that is restored after viral clearance; and (iii) the impact that HCV has on other CV risk factors such as insulin resistance (i.e., the improvement in the HOMA index) ( 25 29 ).…”
Section: Discussionmentioning
confidence: 99%
“…This process may cause a decrease in the content of lipids in the blood, and DAA reverse the above process. When HCV is cleared, the lipids combined with HCV are released, which leads to an increase in the concentration of lipids in the blood [17,19] . The incidence of SAEs during the study period was 7.7% (25/326), none of which were related to the drug.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, serum lipid profiles change in HCV-infected patients treated with direct-acting antivirals (DAA) and this correlates with viral clearance ( 205 , 206 ). Although direct evidence is missing, it is tempting to speculate that modulation of lipid metabolism associated to DAA contributes to viral clearance ( 207 ). In the case of HBV and HDV, metabolism could be manipulated on purpose with drugs to improve viral inhibition, to restore the immune response and finally to achieve functional cure.…”
Section: Discussionmentioning
confidence: 99%