The fault tolerant control (FTC) problem based on rational entropy performance criteria is researched for fuzzy descriptor stochastic distribution networked control (SDNC) systems with packet dropout. The independent Bernoulli distribution is employed to describe the packet dropout in the feedback channel. The static model and the dynamic model of descriptor SDNC systems are built up by the rational square‐root fuzzy logic model (FLM) and the T‐S fuzzy model, respectively. When the given output probability density function (PDF) is not known, the minimization of output randomness becomes an important control target. First, the unknown fault is estimated by developing the fuzzy fault estimation observer. Then, the fault tolerant controller with the fault compensation is designed so that the output of the descriptor SDNC system remains with the minimum uncertainty after the fault occurs. A simulation example is supplied to prove the proposed scheme.