Power control is a major issue in the deployment of 4G mobile networks. Indeed, environmental constraints (relief, Air, noise,...) affect the propagation channels of mobile network systems. The new multimedia services, which consume large amounts of radio resources (frequencies), then lead to an optimization of power control in the cellular coverage in the uplink direction. The aim is to optimize the capacity of radio resources in the cellular coverage based on a COST-231 Walfisch-Ikegami semi-empirical propagation model for power control in the upward direction. It is a question of studying the signal quality between a mobile station and the base station under the constraint of obstacles (Buildings) in order to evaluate the effect of propagation losses on the transmission power in Uplink using different frequencies of the network. Results show that the transmission power is strongly influenced by the path losses that depend on the carrier frequency. Higher the transmission frequency, the less the wave propagates due to propagation and penetration losses due to different barriers.