Soft Devices for High-Resolution Neuro-Stimulation: The Interplay Between Low-Rigidity and Resolution

Vėbraitė, Ieva; Hanein, Yael

doi:10.3389/fmedt.2021.675744

Cited by 10 publications

(12 citation statements)

References 292 publications

(375 reference statements)

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“…polyimide) and compromised electrochemical properties. Moreover, soft neuronal electrodes tend to manifest poor recording performances [15]. The approach we describe here builds on stacked screen-printed carbon on polyurethane films.…”

Section: Resultsmentioning

confidence: 99%

Bi-directional electrical recording and stimulation of the intact retina

Vėbraitė

Bar-Haim

David‐Pur

et al. 2023

Preprint

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Electrophysiological investigations of intact neural circuits are challenged by the gentle and complex nature of neural tissues. Bi-directional electrophysiological interfacing with the retina, in its intact form, is particularly demanding and currently there is no feasible approach to achieve such investigations. Here we present the use of novel soft multi electrode arrays for bi-directional electrophysiological study of the intact retina. To this aim, soft electrode arrays, suitable for stable electrical interfacing with the retina, were developed and tested. The soft probes were designed to accommodate the curvature of the retina in the eye and offer a unique opportunity to study the retina in its intact form. For the first time, we show both electrical recording and stimulation capabilities from the intact retina. In particular, we demonstrate the ability to map retina responses to electrical stimulation in order to reveal conspicuously, stable, direct and indirect responses. These results suggest that intact retinas retain better stability and robustness than ex-vivo retinas.

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Section: Resultsmentioning

confidence: 99%

Bi-directional electrical recording and stimulation of the intact retina

Vėbraitė

Bar-Haim

David‐Pur

et al. 2023

Preprint

Self Cite

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“…TINS can allow clinicians to test and titrate stimulation parameters to determine if patients are good candidates for a more invasive and permanent therapeutic bioelectronic intervention. Finally, besides these examples of acute applications, advances in the technology of conformable cutaneous electrodes [33,34] can allow TINS to be applied chronically in bioelectronic medicine applications. To this end, our work also shows the potential for ultrathin cutaneous electrode arrays based on plastic foils and conducting polymer electrodes.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Stimulation of Peripheral Nerves using Temporally‐Interfering Electrical Fields

Botzanowski

Donahue

Ejneby

et al. 2022

Adv Healthcare Materials

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Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 -4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.

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“…A major design choice is the encapsulation material of the PNI. 73 The encapsulation or support can dominate the PNIs mechanical properties and is commonly made either of a thick layer of silicone [74][75][76][77][78] , or polyimide [79][80][81][82][83][84][85][86] and parylene-C [87][88][89][90][91][92][93][94][95][96] in case of thin film devices. Based on this principle, there are three basic device designs employed for PNIs depicted in Figure 10: extraneural, intraneural and regenerative.…”

Section: Device Designs To Interface With Nervesmentioning

confidence: 99%

“…Miniaturization is an obvious trend in all electronics, and this trend will continue also in the field of stretchable electronics for PNIs. 73 The benefits are straightforward since smaller electrodes give higher resolution and therefore the ability to interact with fewer selected nerve fibers. A promising, still relatively new patterning method for high density patterning of stretchable electronics is laser patterning.…”

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confidence: 99%

Materials and Devices for Stretchable Electronic Nerve Interfaces

Lienemann

2022

Linköping Studies in Science and Technology. Dissertations

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This thesis would not have been possible without the many people who supported me throughout my PhD. Here I wish to express my gratitude:My upmost gratitude goes of course to Klas. When I met you in Zürich I was told you are a brilliant and critical scientist. Now I know you are also a wonderful supervisor. Thanks for caring about me as a person as well as about my PhD. I have extreme respect for you as a supervisor and scientist. I cannot put into big enough words how thankful I am for the tremendous amount of support and knowledge I got from you! I will miss our midnight emails about science. It was an honor to be your first PhD student.Magnus, and the rest of LOE management I would like to thank for making LOE a huge group that still acts like a small one.Besides Klas, I also had several additional (unofficial) mentors that contributed greatly to the success of my PhD.Nadia, my mentor in life. Thanks for ever pushing me to achieve my potential. My motivation for this thesis stemmed to a great deal from wanting to make you and Klas proud. Thanks for believing in me. And thanks for always being there for me. Even commenting on many drafts of this thesis.Marie, my mentor at LOE. Thanks for teaching me the first things I needed to know as a new PhD student, always challenging me to work harder while at the same time luring me with frisbee and beers. Also, thanks for commenting on this thesis and for providing the first instance of the beautiful nerve figure that I have been using ever since in various new versions (also all over in this thesis).Mary, my mentor in the Lab. Thanks for your positive attitude and endless energy to get things done. It was wonderful to work with you on the PigSel project and your comments on this thesis were well appreciated.Aline, my long-distance mentor in Zürich. Thanks for 3 years of bi-weekly support-group meetings of 'people suffering from Klas' gold nanowire fabrication'. You explained and solved a great deal of my problems before they ever could become any up here in the north.To Simon and Johan, my surgeon mentors at Linköping university hospital, my sincerest thanks for happily implanting all the in vivo devices of this thesis over the last 3 years and teaching me firsthand biology.x Riki and Yianni, thanks for being there with me right from the start. You were the reason the SoftEs were not just about electronics, and that my PhD was not just about becoming a doctor, but also about The Doctor. Yianni especially, thanks for being my partner in crime inside and outside the lab. Thanks for caring for the happiness of people with your endless chaotic energy that powered friday beers, movie productions and gifts alike.A big thanks also to the other SoftEs. Thanks for making our group feel like a small family. Nara, thanks for your kind spirit and comments on this thesis. Mohsen, thanks for commenting on the mechanical part of this thesis and taking over all the lab duties from me. Aiman, thanks for being the good soul of the Rubberlab by always being there to talk about science an...

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Soft Devices for High-Resolution Neuro-Stimulation: The Interplay Between Low-Rigidity and Resolution

Cited by 10 publications

References 292 publications

Bi-directional electrical recording and stimulation of the intact retina

Bi-directional electrical recording and stimulation of the intact retina

Noninvasive Stimulation of Peripheral Nerves using Temporally‐Interfering Electrical Fields

Materials and Devices for Stretchable Electronic Nerve Interfaces

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