Soft-lithography fabrication of microfluidic features using thiol-ene formulations

Ashley, John F.; Cramer, Neil B.; Davis, Robert H.; Bowman, Christopher N.

doi:10.1039/c1lc20189a

Cited by 63 publications

(64 citation statements)

References 16 publications

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“…24 Tertiary amines also react with epoxy groups to form zwitterions (11), which subsequently enables nucleophilic displacement in the presence of thiol groups (12). 24,27 The formed zwitterions also participate in epoxy homopolymerization (13).…”

Section: Introductionmentioning

confidence: 99%

Functional off-stoichiometry thiol-ene-epoxy thermosets featuring temporally controlled curing stages via an UV/UV dual cure process

Carlborg

Vastesson

Liu

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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We present a facile two-stage UV/UV activation method for the polymerization of off-stoichiometry thiol-eneepoxy, OSTE1, networks. We show that the handling and processing of these epoxy-based resins is made easier by introducing a material with a controlled curing technique based on two steps, where the first step offers excellent processing capabilities, and the second step yields a polymer with suitable endproperties. We investigate the sequential thiol-ene and thiolepoxy reactions during these steps by studying the mechanical properties, functional group conversion, water absorption, hydrolytic stability, and thermal stability in several different thiol-ene-epoxy formulations. Finally, we conclude that the curing stages can be separated for up to 24 h, which is promising for the usefulness of this technique in industrial applications. INTRODUCTIONThe huge impact of thermoset polymers in applications ranging from biological implants to airplane building materials stems from the ability to precisely control their curing behavior while simultaneously allowing for tuned final properties. Epoxy resins belong to a particular versatile family of polymers that are widely used in industrial applications exhibiting good mechanical end-use properties, excellent bonding to a variety of substrates, and good chemical resistance. Considerable effort has been devoted to develop a plethora of different epoxies with end-properties optimized for many different applications.

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Section: Introductionmentioning

confidence: 99%

Functional off-stoichiometry thiol-ene-epoxy thermosets featuring temporally controlled curing stages via an UV/UV dual cure process

Carlborg

Vastesson

Liu

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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“…There are different methods available for the fabrication of PDMS devices including soft lithography, casting, injection molding, imprinting, hot embossing, laser ablation and others. 22, 62, 63 …”

Section: Microfluidic Platforms For Biomarker Detectionmentioning

confidence: 99%

Biomarker detection for disease diagnosis using cost-effective microfluidic platforms

Sanjay

Dou

et al. 2015

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Early and timely detection of disease biomarkers can prevent the spread of infectious diseases, and drastically decrease the death rate of people suffering from different diseases such as cancer and infectious diseases. Because conventional diagnostic methods have limited application in low-resource settings due to the use of bulky and expensive instrumentation, simple and low-cost point-of-care diagnostic devices for timely and early biomarker diagnosis, is the need of the hour, especially in rural areas and developing nations. The microfluidics technology possesses remarkable features for simple, low-cost, and rapid disease diagnosis. There have been significant advances in the development of microfluidic platforms for diseases biomarker detection. This article reviews recent advances in biomarker detection using cost-effective microfluidic devices for disease diagnosis, with the emphasis on infectious disease and cancer diagnosis in low-resource settings. This review first introduces different microfluidic platforms (e.g. polymer and paper-based microfluidics) used for disease diagnosis, with a brief description of their common fabrication techniques. Then, it highlights various detection strategies for disease biomarker detection using microfluidic platforms, including colorimetric, fluorescence, chemiluminescence, electrochemiluminescence (ECL), and electrochemical detection. Finally, it discusses the current limitations of microfluidics devices for disease biomarker detection and the future perspectives.

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“…Photolithography has been widely used for generating polymer (e.g. SU-8) masters for fabricating microfluidic channels in PDMS via soft lithography [6,7]. However, photolithography requires highly expensive capital facilities and a cleanroom.…”

Section: Introductionmentioning

confidence: 99%

Bio-inspired mammalian hair-fabricated microfluidics

et al. 2013

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Soft-lithography fabrication of microfluidic features using thiol-ene formulations

Cited by 63 publications

References 16 publications

Functional off-stoichiometry thiol-ene-epoxy thermosets featuring temporally controlled curing stages via an UV/UV dual cure process

Functional off-stoichiometry thiol-ene-epoxy thermosets featuring temporally controlled curing stages via an UV/UV dual cure process

Biomarker detection for disease diagnosis using cost-effective microfluidic platforms

Bio-inspired mammalian hair-fabricated microfluidics

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