“…To address the above concerns, numerous formulation strategies such as micelles, emulsions, microemulsions (μEs), vesicles, liposomes, polymer conjugates, polymersomes, nanoparticles, microspheres and nanospheres, lipid carriers, use of prodrugs, drug derivatization, solution phase studies, and penetration enhancers have been used to enhance the drug dissolution rate and bioavailability. − However, owing to the structural flexibility and stability, the use of template μEs can produce nanometer-sized functional APIs of different sizes, shapes, and chemical properties with minimal agglomeration. − The formation of highly wettable functional organic nanopowders through volatile μE templates has many advantages over commonly used methods, such as low cost, simple preparation, low energy investment, and potential for scale expansion into multidose formulations. In addition, the resulting nanopowder is expected to have a high chemical and microbial stability and extended shelf-life. − ,− …”