Soft tissue angiosarcomas

Morales, Pedro; Lindberg, Robert D.; Barkley, Howard T.

doi:10.1016/0360-3016(81)90188-7

Cited by 38 publications

(22 citation statements)

References 13 publications

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“…As a consequence, few data on the clinical management of these malignancies are available, particularly in pediatric age. Angiosarcomas and related high-grade vascular sarcomas are reported to behave aggressively with a high rate of local recurrence and a propensity to metastasize: in adult series, the prognosis is poor, with a 5-year survival rate lower than 20% [5][6][7][8][9][10][11]. Appropriate treatment strategies are undefined as yet and the role of radiotherapy, and of chemotherapy even more, is not clear.…”

Section: Introductionmentioning

confidence: 99%

“…The retrospective study by the Memorial Sloan-Kettering Cancer Center included six patients under 21 years of age diagnosed between 1970 and 1995: four were angiosarcomas and two malignant hemangioendotheliomas [4]. Also, the largest reports on adult patients with malignant vascular tumors included only a few dozen cases [5][6][7][8][9][10]. As a consequence, few data on the clinical management of these malignancies are available, particularly in pediatric age.…”

Section: Introductionmentioning

confidence: 99%

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Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Ferrari

Casanova

Bisogno

et al. 2002

Med. Pediatr. Oncol.

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Angiosarcoma and related malignant vascular tumors are aggressive neoplasms with a poor prognosis; their behavior in children seems no different from their adult counterparts. Complete surgical resection remains the mainstay of treatment, but is probably sufficient in only a minority of cases. Postoperative radiotherapy may have a role and could be added to improve local control. The role of chemotherapy is uncertain, but the high rate of metastatic spread prompts investigation into new chemotherapeutic approaches.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Ferrari

Casanova

Bisogno

et al. 2002

Med. Pediatr. Oncol.

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“…In approximately 50% cases, the head and neck region are involved 5,6) . These tumors usually occur on the scalp in elderly men 5,7,8) . Male predominance is noted, with a male/female ratio of 4:1 4) .…”

Section: Discussionmentioning

confidence: 99%

Clinical Experience regarding Paclitaxel Treatment for Scalp Angiosarcomas: A Preliminary Report

Lin

Liu

et al. 2007

Ann. Cancer Res. Therap.

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Background: Scalp angiosarcoma is an aggressive tumor characterized by a rapid and fatal course. The overall prognosis of scalp angiosarcomas is poor. Recently, paclitaxel was found to be useful for scalp and facial angiosarcomas. Methods: We conducted a retrospective review of paclitaxel in the treatment of scalp angiosarcoma patients who were admitted to the Veterans General Hospital, Taipei from 1996 to 2005 (10 years). Of these patients, 4 initially received paclitaxel and radiotherapy (1 patient underwent surgery in addition to this treatment), and 6 patients underwent either surgery alone or surgery combined with radiotherapy. Disease-free interval and overall survival duration were calculated. Statistic analyses were carried out using Student's t-test. Results: The disease-free interval was significantly prolonged in patients who received paclitaxel in the initial treatment protocol (17.8 vs. 5.7 months, p = 0.016). The overall survival duration was also prolonged in these patients; however, the difference was not significant (26.5 vs. 11.1 months, p = 0.075). The prognosis was poor in the case of disease recurrence or metastases. Conclusions: Although it was difficult to completely eliminate selection bias in this retrospective review due to the limited number of cases, paclitaxel as an initial treatment regimen for primary scalp angiosarcoma after surgery or radiotherapy appeared to prolong the disease-free interval and improve patients' quality of life.

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“…Aggressive treatment with high-dose megavoltage radiation therapy and multi-drug chemotherapy seems to have the best chances of success ( 5 , 8 , 17). In the advanced state of the diseases, responses are few but do occur (15). Proper evaluation of the different treatment modalities can only be assessed in prospective trials sufficiently large to allow for stratification with regard to wellknown prognostical factors, among these histological subtype.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Malignant Haemangiopericytomas and Haemangioendotheliosarcomas

et al. 1988

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Soft tissue angiosarcomas

Cited by 38 publications

References 13 publications

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Clinical Experience regarding Paclitaxel Treatment for Scalp Angiosarcomas: A Preliminary Report

Clinical Features of Malignant Haemangiopericytomas and Haemangioendotheliosarcomas

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